Folate and Human Development

"This multi-author volume reads like a research symposium. Each chapter, written by experts in their field, can be read independently without reference to the others. There is considerable repetition with several chapters providing, for example, overviews of folate metabolism. This book represents an invaluable resource for anyone embarking on research in the field of folic acid and birth defects." - Human Genetics "Each chapter is very well referenced and up-to-date." -Journal of Paediatrics and Child Health "This book represents an invaluable resource for anyone embarking on research in the field of folic acid and birth defects. This book old be a valuable reference source in any department of human genetics." -Human Genetics

• 1 • Animal Models of Folate-Related Neural Tube Defects.- 2 • Genetic Variation in Folate Metabolism: Impacton Development.- 3 • Folate Deficiency and the Molecular Determinants of Chromosome Instability: Possible Link to Meiotic Nondisjunction and Down Syndrome.- 4 • Folic Acid, Vitamin B12, and Genomic Stability of Human Cells.- 5 • Molecular Genetics of Folate Metabolism.- 6 • Folate Receptor-?: An Update.- 7 • Folate, Homocysteine, and Neural Tube Defects.- 8 • Folic Acid and Homocysteine as Risk Factors for Neural Tube Defects.- 9 • Developmental Toxicants Potentially Acting via Folate Perturbation.- 10 • Brain Development and Choline, the Other Methyl Donor.- 11 • Nutrient Interactions Between Folate and Zinc or Copper: Their Possible Implications to Pregnancy Outcome.- 12 • Regulation of Folate Metabolism by Iron.- 13 • A Differential Role for Folate in Developmental Disorders, Vascular Disease, and Other Clinical Conditions: The Importance of Folate Status and Genotype.- 14 • Vascular Disease in Women: Folate and Homocysteine.- 15 • Folate, Homocysteine, and Cardiovascular Disease.