Rebecca Leslie is a consultant anaesthetist, with an interest in perioperative medicine and obstetric anaesthesia, at the Royal United Hospitals NHS Foundation Trust in Bath. She is co-founder of Dr Podcast. Emily Johnson is a consultant anaesthetist, with an interest in teaching and training, at Worcester Acute Hospitals NHS Trust. She is college tutor for the Birmingham School of Anaesthetics and co-founder of Dr Podcast. Alex Goodwin is a consultant in anaesthesia and intensive care medicine at the Royal United Hospitals NHS Foundation Trust in Bath. He was an examiner for the Primary FRCA for 10 years and Director of the College Final FRCA preparation course for 5 years. Samuel Nava is a specialist registrar in anaesthesia at the Severn Deanery in Bristol.

• 1. Physiology: 1.1 Respiratory physiology; 1.1.1 Lung volumes and control of breathing; 1.1.2 Respiratory compliance and surface tension; 1.1.3 Ventilation, perfusion and dead-space; 1.1.4 Alveolar gas equation and shunt; 1.1.5 Pulmonary blood pressure and hypoxic pulmonary vasoconstriction; 1.1.6 Oxyhaemoglobin dissociation; 1.1.7 Altitude physiology; 1.2 Cardiovascular physiology; 1.2.1 Cardiac cycle; 1.2.2 Coronary circulation; 1.2.3 Pacemaker cells; 1.2.4 Valsalva manoeuvre; 1.2.5 Exercise physiology; 1.3 Physiology of the central, peripheral and autonomic nervous systems; 1.3.1 Cerebral circulation; 1.3.2 CSF; 1.3.3 Blood–brain barrier; 1.3.4 Action potentials; 1.3.5 Spinal cord; 1.3.6 Reflex arc; 1.3.7 The autonomic nervous system and adrenoceptors; 1.4 Physiology of the neuromuscular junction; 1.4.1 Neuromuscular junction; 1.4.2 Muscle physiology; 1.4.3 Pain pathways; 1.5 Fluids and renal physiology; 1.5.1 Fluid balance; 1.5.2 Acid–base physiology; 1.5.3 Renal physiology; 1.6 Liver and endocrine physiology; 1.6.1 Glucose and metabolism; 1.6.2 Pituitary and endocrine function; 1.6.3 Thyroid; 1.6.4 Adrenals; 1.6.5 Starvation and the stress response; 1.6.6 The liver and clotting; 1.6.7 Proteins and haemoglobin; 1.7 Immunology; 1.7.1 Immunology; 1.8 Pregnancy; 1.8.1 Physiological changes in pregnancy; 1.8.2 Maternal-fetal circulation; 2. Pharmacology: 2.1 Pharmacological principles; 2.1.1 Pharmacokinetics; 2.1.2 Pharmacodynamics; 2.1.3 Drug interactions; 2.1.4 Agonists and antagonists; 2.1.5 Isomerism; 2.1.6 Pharmacogenetics; 2.2 Intra-venous anaesthetic agents; 2.2.1 Propofol and thiopentone; 2.2.2 Ketamine and etomidate; 2.2.3 Rapid Sequence Induction; 2.3 Inhalational anaesthetic agents; 2.3.1 Inhalational agents; 2.3.2 MAC; 2.3.3 Nitrous oxide; 2.4 Neuromuscular blocking agents and anti-cholinesterase; 2.4.1 Neuromuscular blocking drugs; 2.4.2 Suxamethonium; 2.4.3 Anti-cholinesterases; 2.5 Local anaesthetics; 2.5.1 Local anaesthetics; 2.6 Analgesia agents; 2.6.1 Analgesic agents Dana L Kelly; 2.7 Drugs acting on the nervous system; 2.7.1 Anti-convulsants; 2.7.2 Benzodiazepines; 2.8 Drugs acting on the cardiovascular system; 2.8.1 Anti-hypertensive agents Caroline V Sampson and Samuel Nava; 2.8.2 Anti-arrhythmics; 2.8.3 Inotropes; 2.9 Drugs acting on the gastrointestinal tract; 2.9.1 Drugs acting on the GI tract; 2.9.2 Anti-emetics; 2.9.3 Hypoglycaemics; 2.10 Antibiotics; 2.10.1 Antibiotics; 2.11 Anti-coagulants; 2.11.1 Anti-coagulants; 2.12 Statistics; 2.12.1 Statistical data; 2.12.2 Statistical analysis; 2.13 Drugs used in major haemorrhage; 2.13.1 Tranexamic acid and drugs used in major haemorrhage; 3. Physics: 3.1 SI units; 3.1.1 SI units; 3.2 Biological signals and their measurement; 3.2.1 Biological signals; 3.2.2 Electrocardiogram; 3.2.3 Neuromuscular monitoring; 3.3 Gas flow and its measurement; 3.3.1 Gas laws; 3.3.2 Flow; 3.3.3 Measurement of gas volume and flow; 3.4 Gas supply and delivery; 3.4.1 Cylinders and gas supply; 3.4.2 Breathing systems; 3.4.3 Vaporisers Rebecca; 3.4.4 Soda lime and carbon dioxide absorption; 3.4.5 Scavenging systems; 3.5 Measurement of oxygen, carbon dioxide and anaesthetic agents; 3.5.1 Measurement of anaesthetic agents; 3.5.2 Oxygen measurement; 3.5.3 Pulse oximetry; 3.5.4 pH and CO2 measurement; 3.5.5 Capnography; 3.6 Temperature and humidity; 3.6.1 Heat loss; 3.6.2 Temperature and its measurement; 3.6.3 Humidification; 3.7 Pressure and cardiac output measurement; 3.7.1 Pressure measurement; 3.7.2 Blood pressure measurement; 3.7.3 Resonance and damping; 3.7.4 Intra-cranial pressure measurement; 3.7.5 Cardiac output measurement; 3.8 Electricity; 3.8.1 Electricity; 3.8.2 Electrical safety; 3.9 Equipment; 3.9.1 Defibrillators; 3.9.2 Lasers and diathermy; 3.9.3 Ultrasound.

Rebecca Leslie is a consultant anaesthetist, with an interest in perioperative medicine and obstetric anaesthesia, at the Royal United Hospitals NHS Foundation Trust in Bath. She is co-founder of Dr Podcast. Emily Johnson is a consultant anaesthetist, with an interest in teaching and training, at Worcester Acute Hospitals NHS Trust. She is college tutor for the Birmingham School of Anaesthetics and co-founder of Dr Podcast. Alex Goodwin is a consultant in anaesthesia and intensive care medicine at the Royal United Hospitals NHS Foundation Trust in Bath. He was an examiner for the Primary FRCA for 10 years and Director of the College Final FRCA preparation course for 5 years. Samuel Nava is a specialist registrar in anaesthesia at the Severn Deanery in Bristol.

• 1. Physiology: 1.1 Respiratory physiology; 1.1.1 Lung volumes and control of breathing; 1.1.2 Respiratory compliance and surface tension; 1.1.3 Ventilation, perfusion and dead-space; 1.1.4 Alveolar gas equation and shunt; 1.1.5 Pulmonary blood pressure and hypoxic pulmonary vasoconstriction; 1.1.6 Oxyhaemoglobin dissociation; 1.1.7 Altitude physiology; 1.2 Cardiovascular physiology; 1.2.1 Cardiac cycle; 1.2.2 Coronary circulation; 1.2.3 Pacemaker cells; 1.2.4 Valsalva manoeuvre; 1.2.5 Exercise physiology; 1.3 Physiology of the central, peripheral and autonomic nervous systems; 1.3.1 Cerebral circulation; 1.3.2 CSF; 1.3.3 Blood–brain barrier; 1.3.4 Action potentials; 1.3.5 Spinal cord; 1.3.6 Reflex arc; 1.3.7 The autonomic nervous system and adrenoceptors; 1.4 Physiology of the neuromuscular junction; 1.4.1 Neuromuscular junction; 1.4.2 Muscle physiology; 1.4.3 Pain pathways; 1.5 Fluids and renal physiology; 1.5.1 Fluid balance; 1.5.2 Acid–base physiology; 1.5.3 Renal physiology; 1.6 Liver and endocrine physiology; 1.6.1 Glucose and metabolism; 1.6.2 Pituitary and endocrine function; 1.6.3 Thyroid; 1.6.4 Adrenals; 1.6.5 Starvation and the stress response; 1.6.6 The liver and clotting; 1.6.7 Proteins and haemoglobin; 1.7 Immunology; 1.7.1 Immunology; 1.8 Pregnancy; 1.8.1 Physiological changes in pregnancy; 1.8.2 Maternal-fetal circulation; 2. Pharmacology: 2.1 Pharmacological principles; 2.1.1 Pharmacokinetics; 2.1.2 Pharmacodynamics; 2.1.3 Drug interactions; 2.1.4 Agonists and antagonists; 2.1.5 Isomerism; 2.1.6 Pharmacogenetics; 2.2 Intra-venous anaesthetic agents; 2.2.1 Propofol and thiopentone; 2.2.2 Ketamine and etomidate; 2.2.3 Rapid Sequence Induction; 2.3 Inhalational anaesthetic agents; 2.3.1 Inhalational agents; 2.3.2 MAC; 2.3.3 Nitrous oxide; 2.4 Neuromuscular blocking agents and anti-cholinesterase; 2.4.1 Neuromuscular blocking drugs; 2.4.2 Suxamethonium; 2.4.3 Anti-cholinesterases; 2.5 Local anaesthetics; 2.5.1 Local anaesthetics; 2.6 Analgesia agents; 2.6.1 Analgesic agents Dana L Kelly; 2.7 Drugs acting on the nervous system; 2.7.1 Anti-convulsants; 2.7.2 Benzodiazepines; 2.8 Drugs acting on the cardiovascular system; 2.8.1 Anti-hypertensive agents Caroline V Sampson and Samuel Nava; 2.8.2 Anti-arrhythmics; 2.8.3 Inotropes; 2.9 Drugs acting on the gastrointestinal tract; 2.9.1 Drugs acting on the GI tract; 2.9.2 Anti-emetics; 2.9.3 Hypoglycaemics; 2.10 Antibiotics; 2.10.1 Antibiotics; 2.11 Anti-coagulants; 2.11.1 Anti-coagulants; 2.12 Statistics; 2.12.1 Statistical data; 2.12.2 Statistical analysis; 2.13 Drugs used in major haemorrhage; 2.13.1 Tranexamic acid and drugs used in major haemorrhage; 3. Physics: 3.1 SI units; 3.1.1 SI units; 3.2 Biological signals and their measurement; 3.2.1 Biological signals; 3.2.2 Electrocardiogram; 3.2.3 Neuromuscular monitoring; 3.3 Gas flow and its measurement; 3.3.1 Gas laws; 3.3.2 Flow; 3.3.3 Measurement of gas volume and flow; 3.4 Gas supply and delivery; 3.4.1 Cylinders and gas supply; 3.4.2 Breathing systems; 3.4.3 Vaporisers Rebecca; 3.4.4 Soda lime and carbon dioxide absorption; 3.4.5 Scavenging systems; 3.5 Measurement of oxygen, carbon dioxide and anaesthetic agents; 3.5.1 Measurement of anaesthetic agents; 3.5.2 Oxygen measurement; 3.5.3 Pulse oximetry; 3.5.4 pH and CO2 measurement; 3.5.5 Capnography; 3.6 Temperature and humidity; 3.6.1 Heat loss; 3.6.2 Temperature and its measurement; 3.6.3 Humidification; 3.7 Pressure and cardiac output measurement; 3.7.1 Pressure measurement; 3.7.2 Blood pressure measurement; 3.7.3 Resonance and damping; 3.7.4 Intra-cranial pressure measurement; 3.7.5 Cardiac output measurement; 3.8 Electricity; 3.8.1 Electricity; 3.8.2 Electrical safety; 3.9 Equipment; 3.9.1 Defibrillators; 3.9.2 Lasers and diathermy; 3.9.3 Ultrasound.

Rebecca Leslie is a consultant anaesthetist, with an interest in perioperative medicine and obstetric anaesthesia, at the Royal United Hospitals NHS Foundation Trust in Bath. She is co-founder of Dr Podcast. Emily Johnson is a consultant anaesthetist, with an interest in teaching and training, at Worcester Acute Hospitals NHS Trust. She is college tutor for the Birmingham School of Anaesthetics and co-founder of Dr Podcast. Alex Goodwin is a consultant in anaesthesia and intensive care medicine at the Royal United Hospitals NHS Foundation Trust in Bath. He was an examiner for the Primary FRCA for 10 years and Director of the College Final FRCA preparation course for 5 years. Samuel Nava is a specialist registrar in anaesthesia at the Severn Deanery in Bristol.

• 1. Physiology: 1.1 Respiratory physiology; 1.1.1 Lung volumes and control of breathing; 1.1.2 Respiratory compliance and surface tension; 1.1.3 Ventilation, perfusion and dead-space; 1.1.4 Alveolar gas equation and shunt; 1.1.5 Pulmonary blood pressure and hypoxic pulmonary vasoconstriction; 1.1.6 Oxyhaemoglobin dissociation; 1.1.7 Altitude physiology; 1.2 Cardiovascular physiology; 1.2.1 Cardiac cycle; 1.2.2 Coronary circulation; 1.2.3 Pacemaker cells; 1.2.4 Valsalva manoeuvre; 1.2.5 Exercise physiology; 1.3 Physiology of the central, peripheral and autonomic nervous systems; 1.3.1 Cerebral circulation; 1.3.2 CSF; 1.3.3 Blood–brain barrier; 1.3.4 Action potentials; 1.3.5 Spinal cord; 1.3.6 Reflex arc; 1.3.7 The autonomic nervous system and adrenoceptors; 1.4 Physiology of the neuromuscular junction; 1.4.1 Neuromuscular junction; 1.4.2 Muscle physiology; 1.4.3 Pain pathways; 1.5 Fluids and renal physiology; 1.5.1 Fluid balance; 1.5.2 Acid–base physiology; 1.5.3 Renal physiology; 1.6 Liver and endocrine physiology; 1.6.1 Glucose and metabolism; 1.6.2 Pituitary and endocrine function; 1.6.3 Thyroid; 1.6.4 Adrenals; 1.6.5 Starvation and the stress response; 1.6.6 The liver and clotting; 1.6.7 Proteins and haemoglobin; 1.7 Immunology; 1.7.1 Immunology; 1.8 Pregnancy; 1.8.1 Physiological changes in pregnancy; 1.8.2 Maternal-fetal circulation; 2. Pharmacology: 2.1 Pharmacological principles; 2.1.1 Pharmacokinetics; 2.1.2 Pharmacodynamics; 2.1.3 Drug interactions; 2.1.4 Agonists and antagonists; 2.1.5 Isomerism; 2.1.6 Pharmacogenetics; 2.2 Intra-venous anaesthetic agents; 2.2.1 Propofol and thiopentone; 2.2.2 Ketamine and etomidate; 2.2.3 Rapid Sequence Induction; 2.3 Inhalational anaesthetic agents; 2.3.1 Inhalational agents; 2.3.2 MAC; 2.3.3 Nitrous oxide; 2.4 Neuromuscular blocking agents and anti-cholinesterase; 2.4.1 Neuromuscular blocking drugs; 2.4.2 Suxamethonium; 2.4.3 Anti-cholinesterases; 2.5 Local anaesthetics; 2.5.1 Local anaesthetics; 2.6 Analgesia agents; 2.6.1 Analgesic agents Dana L Kelly; 2.7 Drugs acting on the nervous system; 2.7.1 Anti-convulsants; 2.7.2 Benzodiazepines; 2.8 Drugs acting on the cardiovascular system; 2.8.1 Anti-hypertensive agents Caroline V Sampson and Samuel Nava; 2.8.2 Anti-arrhythmics; 2.8.3 Inotropes; 2.9 Drugs acting on the gastrointestinal tract; 2.9.1 Drugs acting on the GI tract; 2.9.2 Anti-emetics; 2.9.3 Hypoglycaemics; 2.10 Antibiotics; 2.10.1 Antibiotics; 2.11 Anti-coagulants; 2.11.1 Anti-coagulants; 2.12 Statistics; 2.12.1 Statistical data; 2.12.2 Statistical analysis; 2.13 Drugs used in major haemorrhage; 2.13.1 Tranexamic acid and drugs used in major haemorrhage; 3. Physics: 3.1 SI units; 3.1.1 SI units; 3.2 Biological signals and their measurement; 3.2.1 Biological signals; 3.2.2 Electrocardiogram; 3.2.3 Neuromuscular monitoring; 3.3 Gas flow and its measurement; 3.3.1 Gas laws; 3.3.2 Flow; 3.3.3 Measurement of gas volume and flow; 3.4 Gas supply and delivery; 3.4.1 Cylinders and gas supply; 3.4.2 Breathing systems; 3.4.3 Vaporisers Rebecca; 3.4.4 Soda lime and carbon dioxide absorption; 3.4.5 Scavenging systems; 3.5 Measurement of oxygen, carbon dioxide and anaesthetic agents; 3.5.1 Measurement of anaesthetic agents; 3.5.2 Oxygen measurement; 3.5.3 Pulse oximetry; 3.5.4 pH and CO2 measurement; 3.5.5 Capnography; 3.6 Temperature and humidity; 3.6.1 Heat loss; 3.6.2 Temperature and its measurement; 3.6.3 Humidification; 3.7 Pressure and cardiac output measurement; 3.7.1 Pressure measurement; 3.7.2 Blood pressure measurement; 3.7.3 Resonance and damping; 3.7.4 Intra-cranial pressure measurement; 3.7.5 Cardiac output measurement; 3.8 Electricity; 3.8.1 Electricity; 3.8.2 Electrical safety; 3.9 Equipment; 3.9.1 Defibrillators; 3.9.2 Lasers and diathermy; 3.9.3 Ultrasound.