Michael G. Irwin is the Daniel C. K. Yu Professor in Anaesthesiology at the University of Hong Kong. A specialist with extensive clinical and academic experience, he has published widely on intravenous anaesthesia, pharmacology, and perioperative medicine, and contributed to major textbooks. He has held leadership roles in hospitals and professional societies, served on editorial boards including Anaesthesia, and chaired the 2016 World Congress of Anaesthesiologists. Claire C. Nestor is a Consultant Anaesthetist and Ambulatory Surgery lead at Tallaght University Hospital. Previously, she was an Assistant Professor at the Department of Anaesthesiology, University of Hong Kong. She serves on the editorial board of both Anaesthesia (associate editor) and Anaesthesia & Intensive Care Medicine (editor). She is an enthusiastic teacher and an advocate of sustainable anaesthesia practices.

• Foreword to the first edition Iain Glen; Introduction Michael G. Irwin and Claire C. Nestor; 1. The advantages of TIVA Michael G. Irwin, Claire C. Nestor and Thomas Emms; 2. What is the Keo in pharmacokinetics and dynamics? Frank H. Engbers; 3. TCI for TIVA, what a good idea! A historical perspective of the development of TCI Michael G. Irwin and Gavin N. C. Kenny; 4. Propofol pharmacology Kane O. Pryor and Paul S. Myles; 5. Pharmacokinetics Douglas J. Eleveld; 6. TIVA safety – errors and solutions, tips and tricks Laura Flood and Robert James Fleming; 7. Processed EEG monitoring Mark Barley; 8. The role and effects of adjuvant medications Vivian Man Ying Yuen; 9. Preventative analgesia with total intravenous anesthesia John Pham, Kasi Goodwin and Alastair Moody; 10. Smooth recovery Anthony Ray Absalom and Johann Klaus Götz Wietasch; 11. TIVA in emergency surgery: delivering safe anaesthesia under pressure Andrew W. Smith, Claire C. Nestor and Michael G. Irwin; 12. Paediatric TIVA Brian Anderson; 13. TIVA in the elderly Musab Elhadi and Claire Frith-Keyes; 14. Extreme weights: the roller coaster of intravenous anaesthesia L. Ignacio Cortínez, Carolina Frederico and Brian J. Anderson; 15. TIVA in obstetrics Rosemarie Kearsley and Caoimhe Duffy; 16. Sustainability in total intravenous anaesthesia Rebecca Crosby, Peter Brooks, Li Fang and Clifford L. Shelton; 17. To infinity and beyond: the future of TIVA Michele Introna, Zahra Moaiyeri and Francisco A. Lobo; 18. Friend or foe: implications of anaesthesia on cancer surgery Eimear Keane, Dulmi Nawarathna and Thomas P. Wall; 19. TIVA in exceptional circumstances: TIVA in a pandemic and drug shortages Lauren M. Hughes, Claire C. Nestor and Michael G. Irwin; 20. TIVA for specific procedures and diseases Paul Andrew Stewart, Claire C. Nestor and Michael G. Irwin; 21. Emerging drugs for TIVA Madhumitha Gnanamoorthy, Claire C. Nestor and Michael G. Irwin; Index.