Bokus
Lijuan Yuan - Vaccine Efficacy Evaluation, Inbunden

Inbunden, Engelska, 2022

Vaccine Efficacy Evaluation

The Gnotobiotic Pig Model

Av Lijuan Yuan

Del i serien Pocket Guides to Biomedical Sciences

2188 kr

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Beskrivning
Testing the immunogenicity, protective efficacy and safety in animal models is a crucial step in vaccine development. Pigs raised in germ-free environments, called gnotobiotic (Gn) pigs, are one of the most useful animal models for testing vaccines. The Gn pig model is a widely accepted model for studying pathogenesis and immunity and an ideal model for pre-clinical testing for the safety and efficacy of enteric viral vaccines. Through these studies and others, the Gn pig model has been established as the most reliable animal model for pre-clinical evaluation of human rotavirus and norovirus vaccines. This book provides detailed information on establishing Gn pig models, determining a proper virus inoculum pool and challenge dose, measuring protection and calculating efficacy, and delineating intestinal and systemic immune responses associated with the protection.Key Features Provides a natural history of human rotavirus and norovirus infection in Gn pigs Establishes the optimal virus challenge doses in Gn pigs for vaccine evaluationEvaluates various candidate rotavirus and norovirus vaccinesDiscusses human gut microbiota transplanted Gn pig modelsDocuments the role of probiotics and rice bran as prophylactics and vaccine adjuvants
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Lijuan Yuan is a Professor of Virology and Immunology in the Virginia-Maryland Vet Med’s Department of Biomedical Sciences & Pathobiology. Dr. Yuan studies the interactions between enteric viruses and the host immune system. Her lab's research interests are focused on the pathogenesis and innate and adaptive immune responses induced by enteric viruses, especially noroviruses and rotaviruses, and on the development of safer and more effective vaccines as well as passive immune prophylaxis and therapeutics against viral gastroenteritis. These studies utilize wild-type, gene knock-out, and human gut microbiota transplanted gnotobiotic pig models of human rotavirus and norovirus infection and diseases and cell culture model of rotavirus infection. Currently, the Yuan lab is evaluating the immunogenicity and protective efficacy of several candidate novel rotavirus and norovirus vaccines and engineered probiotic yeast Saccharomyces boulardii secreting multi-specific single-domain antibodies as novel prophylaxis against both noroviruses and Clostridioides difficile toxins. See: https://vetmed.vt.edu/people/faculty/yuan-lijuan.html

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