Pocket Guides to Biomedical Sciences – serie

Open Access Data is emerging as a source for cutting edge scholarship. This concise book provides guidance from generating a research idea to publishing results. Both young researchers and well-established scholars can use this book to upgrade their skills with respect to emerging data sources, analysis, and even post-publishing promotion. At the end of each chapter, a tutorial simulates a real example, allowing readers to apply what they learned about accessing open data, and analyzing this data to reach the results. This book can be of use by established researchers analyzing data, publishing, and actively promoting ongoing and research.Key selling features:Describes the steps, from A-Z, for doing open data researchIncludes interactive tutorials following each chapterProvides guidelines for readers so that they can use their own accessed open dataReviews recent software and websites promoting and enabling open data researchSupplements websites which update recent open data sources

Open Access Data is emerging as a source for cutting edge scholarship. This concise book provides guidance from generating a research idea to publishing results. Both young researchers and well-established scholars can use this book to upgrade their skills with respect to emerging data sources, analysis, and even post-publishing promotion. At the end of each chapter, a tutorial simulates a real example, allowing readers to apply what they learned about accessing open data, and analyzing this data to reach the results. This book can be of use by established researchers analyzing data, publishing, and actively promoting ongoing and research.Key selling features:Describes the steps, from A-Z, for doing open data researchIncludes interactive tutorials following each chapterProvides guidelines for readers so that they can use their own accessed open dataReviews recent software and websites promoting and enabling open data researchSupplements websites which update recent open data sources

Testing the immunogenicity, protective efficacy and safety in animal models is a crucial step in vaccine development. Pigs raised in germ-free environments, called gnotobiotic (Gn) pigs, are one of the most useful animal models for testing vaccines. The Gn pig model is a widely accepted model for studying pathogenesis and immunity and an ideal model for pre-clinical testing for the safety and efficacy of enteric viral vaccines. Through these studies and others, the Gn pig model has been established as the most reliable animal model for pre-clinical evaluation of human rotavirus and norovirus vaccines. This book provides detailed information on establishing Gn pig models, determining a proper virus inoculum pool and challenge dose, measuring protection and calculating efficacy, and delineating intestinal and systemic immune responses associated with the protection.Key Features Provides a natural history of human rotavirus and norovirus infection in Gn pigs Establishes the optimal virus challenge doses in Gn pigs for vaccine evaluationEvaluates various candidate rotavirus and norovirus vaccinesDiscusses human gut microbiota transplanted Gn pig modelsDocuments the role of probiotics and rice bran as prophylactics and vaccine adjuvants

Viruses do not behave as other microbes; their life cycles require infecting healthy cells, commandeering their cellular apparatus, replicating and then killing the host cell. Methods for virus detection and identification have been developed only in the past few decades. These recently developed methods include molecular, physical, and proteomic techniques. All these approaches (Electron Microscopy, Molecular, Direct Counting, and Mass Spectrometry Proteomics) to detection and identification are reviewed in this succinct volume. It is written in approachable language with enough detail for trained professionals to follow and want to recommend to others.Key Features Covers common detection methods Reviews the history of detection from antiquity to the present Documents the strengths and weaknesses of various detection methods Describes how to detect newly discovered viruses Recommends specific applications for clinical, hospital, environmental, and public health uses

Viruses do not behave as other microbes; their life cycles require infecting healthy cells, commandeering their cellular apparatus, replicating and then killing the host cell. Methods for virus detection and identification have been developed only in the past few decades. These recently developed methods include molecular, physical, and proteomic techniques. All these approaches (Electron Microscopy, Molecular, Direct Counting, and Mass Spectrometry Proteomics) to detection and identification are reviewed in this succinct volume. It is written in approachable language with enough detail for trained professionals to follow and want to recommend to others.Key Features Covers common detection methods Reviews the history of detection from antiquity to the present Documents the strengths and weaknesses of various detection methods Describes how to detect newly discovered viruses Recommends specific applications for clinical, hospital, environmental, and public health uses

Genome-editing methods are becoming routine tools for molecular and cell biologists. Such tools include ZFNs, CRISPR, megaTALs and TALENs. These tools are revolutionizing the creation of precisely manipulated genomes to modify the characteristics of organisms or cells. Additionally, gene drives have altered the way we understand inheritance laws. They give us the ability to have total control of the inheritance of traits of choice and importance. This succinct volume summarizes the history, principles and applications – as well as the advantages and disadvantages – of each of these tools and various kinds of gene drives. The book is part of a program to produce books helpful to students and faculties of science at colleges and universities. This volume in the Pocket Guides to Biomedical Sciences series will help demystify these technologies. The book fills the gap between established conventional methods and the novel and exciting newly introduced tools of genome editing and gene drives. It will help young scientists understand the emerging genome-editing tools and gene drives, thereby promoting related research and adoption.Key Features Extensively reviews the current genome-editing tools and gene drives Clarifies the targeting mechanisms and specificity of genome-editing tools Details many different types of natural and synthetic gene drives Highlights concerns with gene drives and genome-editing toolsRelated TitlesBrown, T. A. Genomes 4 (ISBN 978-0-8153-4508-4)Samuelsson, T. The Human Genome in Health and Disease: A Story in Four Letters (ISBN 978-0-8153-4591-6)Soh, J., et al. Genome Annotation (ISBN 978-1-4398-4117-4)

Genome-editing methods are becoming routine tools for molecular and cell biologists. Such tools include ZFNs, CRISPR, megaTALs and TALENs. These tools are revolutionizing the creation of precisely manipulated genomes to modify the characteristics of organisms or cells. Additionally, gene drives have altered the way we understand inheritance laws. They give us the ability to have total control of the inheritance of traits of choice and importance. This succinct volume summarizes the history, principles and applications – as well as the advantages and disadvantages – of each of these tools and various kinds of gene drives. The book is part of a program to produce books helpful to students and faculties of science at colleges and universities. This volume in the Pocket Guides to Biomedical Sciences series will help demystify these technologies. The book fills the gap between established conventional methods and the novel and exciting newly introduced tools of genome editing and gene drives. It will help young scientists understand the emerging genome-editing tools and gene drives, thereby promoting related research and adoption.Key Features Extensively reviews the current genome-editing tools and gene drives Clarifies the targeting mechanisms and specificity of genome-editing tools Details many different types of natural and synthetic gene drives Highlights concerns with gene drives and genome-editing toolsRelated TitlesBrown, T. A. Genomes 4 (ISBN 978-0-8153-4508-4)Samuelsson, T. The Human Genome in Health and Disease: A Story in Four Letters (ISBN 978-0-8153-4591-6)Soh, J., et al. Genome Annotation (ISBN 978-1-4398-4117-4)

Testing the immunogenicity, protective efficacy and safety in animal models is a crucial step in vaccine development. Pigs raised in germ-free environments, called gnotobiotic (Gn) pigs, are one of the most useful animal models for testing vaccines. The Gn pig model is a widely accepted model for studying pathogenesis and immunity and an ideal model for pre-clinical testing for the safety and efficacy of enteric viral vaccines. Through these studies and others, the Gn pig model has been established as the most reliable animal model for pre-clinical evaluation of human rotavirus and norovirus vaccines. This book provides detailed information on establishing Gn pig models, determining a proper virus inoculum pool and challenge dose, measuring protection and calculating efficacy, and delineating intestinal and systemic immune responses associated with the protection.Key Features Provides a natural history of human rotavirus and norovirus infection in Gn pigs Establishes the optimal virus challenge doses in Gn pigs for vaccine evaluationEvaluates various candidate rotavirus and norovirus vaccinesDiscusses human gut microbiota transplanted Gn pig modelsDocuments the role of probiotics and rice bran as prophylactics and vaccine adjuvants

This book summarizes the development and statistical validation of a guinea pig model as an alternative for potency testing of the viral antigens included in combined vaccines applied in cattle to control the respiratory, reproductive, and neonatal calf diarrhea syndromes. The model allows, in one serum sample, to test the vaccine quality for all the viral antigens included in aqueous as well as in oil-adjuvanted formulations of bovine vaccines. The methodology proposed for the control of bovine herpes virus, parainfluenza, and rotavirus were recommended by CAMEVET as guidelines for the 30 countries in the forum, including the US.Key FeaturesReviews combined vaccines used for cattleSummarizes animal models used for vaccine testingFocuses on bovine herpesviruses, rotaviruses, parainfluenza, and bovine viral diarrhea virusProvides guidance on the effectiveness of the Guinea Pig model for testing vaccine immunogenicity

The Guide to AIDS is succinct review of HIV/AIDS from a human-interest perspective. Chapters focus on some of the common patterns and prevention of HIV transmission and debunks misconceptions about HIV and AIDS. Brief descriptions the human immune system and epidemiology of HIV are included. The cultural component of disease, treatment and living with AIDS is central to much of this guide intended to synthesize, explain and de-mystify HIV and AIDS.

Pocket Guide to Bacterial Infections provides information pertinent to the behaviour of bacterial cells during their interactions with different cell types of multiple host systems. This book will present the role of various bacterial pathogens affecting the host system. The book is to be organized flexibly so that chapters and topics are arranged with continuity from the former chapters. Each chapter has been made as self-contained as possible to promote this flexibility. This book will discuss each of the virulence properties of the bacteria with reference to their interacting hosts in a larger perspective.Kwey selling features:Summarizes the role various bacterial pahtogens affect the host systemReviews recent advances for combating different types of bacterial infections that infect different body partsDesigned as an effective teaching and research tool providing up to date information on bacterial infectionsDefines important termsWritten in a readable and direct writing style

Pocket Guide to Bacterial Infections provides information pertinent to the behaviour of bacterial cells during their interactions with different cell types of multiple host systems. This book will present the role of various bacterial pathogens affecting the host system. The book is to be organized flexibly so that chapters and topics are arranged with continuity from the former chapters. Each chapter has been made as self-contained as possible to promote this flexibility. This book will discuss each of the virulence properties of the bacteria with reference to their interacting hosts in a larger perspective.Kwey selling features:Summarizes the role various bacterial pahtogens affect the host systemReviews recent advances for combating different types of bacterial infections that infect different body partsDesigned as an effective teaching and research tool providing up to date information on bacterial infectionsDefines important termsWritten in a readable and direct writing style

The Pocket Guide to Mycological Diagnosis provides useful and concise information for microbiologists and professionals diagnosing the most medically relevant fungal species. Cellular and molecular techniques, immunological methods, and more accurate microscopy equipment available in most mycology laboratories now make diagnosis more routine. Furthermore, information regarding medical mycology, including identification of specific fungal pathogens, is widely available. This book helps mycologists address the emerging challenges of diagnosis.Key Features Succinct summary of fungal disease diagnosis Includes opportunistic fungal infections that can afflict immunocompromised patients Permits the identification of common fungal pathogens Reviews antifungal drugsRelated TitlesGhannoum, M. A. & John R. Perfect, eds. Antifungal Therapy, 2nd ed. (ISBN 978-1-4987-6814-6)Miyaji, M., ed. Animal Models in Medical Mycology (ISBN 978-1-3158-9059-3)Razzaghi-Abyaneh, M., M. Shams-Ghahfarokhi and M. Rai, eds. Medical Mycology: Current Trends and Future Prospects (ISBN 978-1-4987-1421-1)

The Pocket Guide to Mycological Diagnosis provides useful and concise information for microbiologists and professionals diagnosing the most medically relevant fungal species. Cellular and molecular techniques, immunological methods, and more accurate microscopy equipment available in most mycology laboratories now make diagnosis more routine. Furthermore, information regarding medical mycology, including identification of specific fungal pathogens, is widely available. This book helps mycologists address the emerging challenges of diagnosis.Key Features Succinct summary of fungal disease diagnosis Includes opportunistic fungal infections that can afflict immunocompromised patients Permits the identification of common fungal pathogens Reviews antifungal drugsRelated TitlesGhannoum, M. A. & John R. Perfect, eds. Antifungal Therapy, 2nd ed. (ISBN 978-1-4987-6814-6)Miyaji, M., ed. Animal Models in Medical Mycology (ISBN 978-1-3158-9059-3)Razzaghi-Abyaneh, M., M. Shams-Ghahfarokhi and M. Rai, eds. Medical Mycology: Current Trends and Future Prospects (ISBN 978-1-4987-1421-1)

Tumors and Cancers: Endocrine Glands – Blood – Marrow – Lymph provides succinct reviews of neoplastic growths disrupting normal functions of affected structures. Each chapter presents a state of the art summary of tumor/cancer of a particular type in relation to its biology, epidemiology, disease mechanisms, clinical signs, diagnosis, treatment and prognosis.

The Guide to AIDS is succinct review of HIV/AIDS from a human-interest perspective. Chapters focus on some of the common patterns and prevention of HIV transmission and debunks misconceptions about HIV and AIDS. Brief descriptions the human immune system and epidemiology of HIV are included. The cultural component of disease, treatment and living with AIDS is central to much of this guide intended to synthesize, explain and de-mystify HIV and AIDS.key selling featurws: Provides a simplified brief review of HIV and the disease it causes - AIDSDebunks myths associated with HIV transmision such as through mosquito bitesIdentifies simple and low cost ways to prevent the transmission and spread of HIVIllustrates the crucial role that culture plays in the prevention of HIV spread and AIDS treatmentPuts a human face on the problem of diagnosing and living with AIDS

Solving intractable biotechnological questions of evolution, medicine, and genetics is now easier due to methods permitting the rapid analysis of molecular sequence data. These advances have exposed ethical and policy concerns. How would genomic information be used and by whom? Should individuals be able to make decisions regarding their own genomic data? How accurate are these genetic tests and how should they be regulated? These and other ethical conundrums are the subject of this book. Bioethicists, biomedical policy experts and lawyers, physicians, nursing and allied health students as well as science educators will find this book helpful and engaging in exploring the complexities of modern evolutionary, genetic and biomedical data.

Solving intractable biotechnological questions of evolution, medicine, and genetics is now easier due to methods permitting the rapid analysis of molecular sequence data. These advances have exposed ethical and policy concerns. How would genomic information be used and by whom? Should individuals be able to make decisions regarding their own genomic data? How accurate are these genetic tests and how should they be regulated? These and other ethical conundrums are the subject of this book. Bioethicists, biomedical policy experts and lawyers, physicians, nursing and allied health students as well as science educators will find this book helpful and engaging in exploring the complexities of modern evolutionary, genetic and biomedical data.

A Guide to Cancer: Origins and Revelations unfolds the complex and fascinating topic of cancer in two ways: firstly, no specialist knowledge is assumed on the part of the reader, and secondly, despite the serious nature of the topics, the book aims to stimulate interest, provoke thought, and paradoxically entertain. It takes an array of complex topics and breaks them down in clear, concise terms, so that anyone with a basic knowledge of science can understand. The book is aimed at the general public as well as students of biological subjects, first and second year university students, and researchers in the nascent field of cancer genomics.

A Guide to Cancer: Origins and Revelations unfolds the complex and fascinating topic of cancer in two ways: firstly, no specialist knowledge is assumed on the part of the reader, and secondly, despite the serious nature of the topics, the book aims to stimulate interest, provoke thought, and paradoxically entertain. It takes an array of complex topics and breaks them down in clear, concise terms, so that anyone with a basic knowledge of science can understand. The book is aimed at the general public as well as students of biological subjects, first and second year university students, and researchers in the nascent field of cancer genomics.