Radiotheranostics - A Primer for Medical Physicists II

Cari (Caridad) Borrás is a medical physicist in Washington DC, where she works as an international consultant and lecturer, and has an adjunct faculty position at the George Washington University School of Medicine and Health Sciences. She holds a Doctor of Science (Physics) degree from the Universitat de Barcelona, Catalonia, Spain. The research for her doctoral thesis –on the dosimetry and the radiation effects of Astatine-211 on the development of the rat embryo– was performed at Thomas Jefferson University in Philadelphia PA, USA, under a Fulbright scholarship (1966-1973). She is certified in Radiological Physics by the American Board of Radiology (ABR) and in Medical Health Physics by the American Board of Medical Physics and keeps both certifications current. She worked as a radiological physicist at the West Coast Cancer Foundation in San Francisco CA (1974-1988), directed the Radiological Health Program of the Pan American / World Health Organization in Washington DC (1988-2003), joined as Senior Scientist and Director of Special Programs the Institute for Radiological Image Sciences, Inc. in Frederick MD (2003-2004), and was a Visiting Professor at the Universidade Federal de Pernambuco in Recife, Brazil, where she supervised graduated students in medical radiation dosimetry (2009-2011). She is a member of the American Association of Physicists in Medicine (AAPM), American College of Radiology (ACR), Health Physics Society (HPS), Society of Nuclear Medicine and Molecular Imaging, and the Spanish Medical Physics (SEFM) and Radiation Protection (SEPR) Societies. She has served on numerous committees of these societies as well as the International Organization for Medical Physics (IOMP), where she chaired the Science Committee (2000-2009); the International Union for Physical and Engineering Sciences in Medicine (IUPESM), where she co-chaired/chaired the Health Technology Task Group (2009-2015), and the European Federation of Organisations for Medical Physics, where she currently is a member of the Scientific Committee. She has lectured in more than 300 courses/congresses, many of which she organized; authored around 100 publications, among them five book chapters, and has edited two books. She is a Fellow of ACR, AAPM, IOMP, HPS and IUPESM, and has been given awards by SEFM, AAPM, IOMP, Latin American Medical Physics Association, American College of Clinical Engineering, ACR and ABR.

• List of Common AcronymsPart 1 – IntroductionChapter 1. Radiotheranostics: Challenges TodayPart 2 – Radiochemistry and RadiobiologyChapter 2. Radiopharmaceutical Preparations and Radiolabeling StrategiesChapter 3. New Insights Into the Radiation Biology of RadiotheranosticsChapter 4. Radiation Embryology: Human and Animal StudiesPart 3 – Particle DosimetryChapter 5. Alpha- and Beta-particle Therapy and DosimetryChapter 6. Auger EmittersChapter 7. Positrons: Their Potential Role in Radionuclide TherapyPart 4 – Dosimetry FormalismsChapter 8. Biokinetic Modelling For Radionuclide DosimetryChapter 9. Standardized Tumor and Organ DosimetryChapter 10. Image-based Dosimetry ProceduresChapter 11. Combining External Beam Radiotherapy and Radionuclide TherapyChapter 12. Uncertainties in Dose CalculationsPart 5 – SafetyChapter 13. Design, Shielding, and Operational Radiation Safety Aspects of the Radiotheranostic FacilityChapter 14. Management of Deceased Patients Under Treatment (Radioactive Cadavers)Chapter 15. Radiopharmaceutical Regulatory RequirementsPart 6 – Future Directions and OpportunitiesChapter 16. The Economics of TheranosticsChapter 17. Artificial intelligence in Radiotheranostics