Handbook of Nuclear Medicine and Molecular Imaging for Physicists - Three Volume Set

Michael Ljungberg is a Professor at Medical Radiation Physics, Lund, Lund University, Sweden. He started his research in the Monte Carlo field in 1983 through a project involving a simulation of whole-body counters but later changed the focus to more general applications in nuclear medicine imaging and SPECT. As a parallel to his development of the Monte Carlo code SIMIND, he started working in 1985 with quantitative SPECT and problems related to attenuation and scatter. After obtaining his PhD in 1990, he received a research assistant position that allowed him to continue developing SIMIND for quantitative SPECT applications and establish successful collaborations with international research groups. At this time, the SIMIND program also became used world-wide. Dr. Ljungberg later became an associate professor in 1994 and he received, after a couple of years working clinically as a nuclear medicine medical physicist, a full professorship in the Science Faculty at Lund University in 2005. He became the Head of the Department of Medical Radiation Physics at Lund University in 2013 and a full professor in the Medical Faculty at Lund University in 2015. Beside from the development of SIMIND to include also new camera system such as CZT detectors, his research includes an extensive project in oncological nuclear medicine, where he, with colleagues, develop dosimetry methods based on quantitative SPECT, Monte-Carlo absorbed dose calculations, and methods for accurate 3D dose planning for internal radionuclide therapy. During the recent years, his has been focused on implementing Monte-Carlo based image reconstruction in SIMIND. He is also involved in the undergraduate education of medical physicists and bio-medical engineers and are supervising MSc and PhD students. In 2012, Professor Ljungberg became a member of the European Association of Nuclear Medicines task group on Dosimetry and served there for six years. He has published over 100 original papers, 18 conference proceedings, 18 books and book chapters and 14 peer-reviewed review papers.

"This is a high quality, three volume set, bound in striking glossy red and black. The formatting is clear and the text printed in dark grey ink, an unusual choice that nevertheless makes the dense pages of text, formulae, grey and white diagrams and photographs an easier read during prolonged study. Edited by professor of medical radiation physics Michael Ljungberg from Lund University, a renowned authority on Monte Carlo modelling, it includes contributions from medical physicists who will be familiar names to many in the UK community. The content is predominantly written from a European perspective, although a chapter on the IAEA is included to provide some broader international context. Volume I covers instrumentation and imaging procedures. This wideranging volume opens with a brief history of nuclear medicine before moving on to discuss radiation and detector physics, and the details of gamma cameras, PET, CT, MR and hybrid systems, as well as more niche imaging technologies. There are shorter chapters on acquisition protocols for clinical imaging, providing examples of how this knowledge is applied in practice. Volume II covers modelling, dosimetry and radiation protection. This volume provides the reader with a grounding in biostatistics, radiobiology, kinetic analysis and radiation protection, before a detailed and focused discussion of the application of these principles in dosimetry and radiation safety. Volume III covers radiopharmaceuticals and clinical applications. It begins with an overview of the principles behind radiopharmacy before moving on to the details of radiopharmaceuticals, all aspects of their production, and both clinical and research applications…The set covers a wide range of relevant material…each chapter stands on its own merits and provides valuable, in-depth information from subject experts…Ljundberg’s trilogy would make an excellent addition to any nuclear medicine department library."— Dr Heather Williams, consultant medical physicist, The Christie NHS Foundation Trust, Manchester in RAD Magazine, May, 2023

• Volume I: Instrumentation and Images Processing. 1. The History of Nuclear Medicine 2. Basics of Nuclear Physics 3. Basics of Radiation Interaction in Matter 4. Radionuclide Production 5. Radiometry 6. Scintillation Detectors 7. Semiconductor Detectors 8. Gamma Spectroscopy 9. Properties of the Digital Image 10. Digital Image Processing 11. Machine-Learning 12. Image File Structures in Nuclear Medicine 13. The Scintillation Camera 14. Collimators for Gamma Ray Imaging 15. Image Acquisition Protocols 16. Single Photon Emission Computed Tomography (SPECT) and SPECT/CT Hybrid Imaging 17. Dedicated Tomographic Single Photon Systems 18. Positron Emission Tomography (PET) 19. Dead Time Effects in Nuclear Medicine Imaging Studies 20. Principles of Iterative Reconstruction for Emission Tomography 21. Clinical Molecular PET/CT Hybrid Imaging 22. Clinical Molecular PET/MRI Hybrid Imaging 23. Quality Assurance of Nuclear Medicine Systems 24. Calibration and Traceability 25. Activity Quantification from Planar images 26. Quantitation in Emission Tomography 27. Multicenter studies: Hardware and Software Requirements 28. Pre-Clinical Molecular Imaging Systems 29. Monte Carlo simulations of Nuclear Medicine Imaging Systems 30. Beta and Alpha Particle Autoradiography 31. Principles behind Computed Tomography (CT) 32. Principles behind Magnetic Resonance Imaging (MRI) Volume II: Dosimetry and Radiation Protection . 1. Introduction to Biostatistics 2. Radiobiology 3. Diagnostic Dosimetry 4. Time-Activity Curves: Data, Models, Curve Fitting and Model Selection 5. Tracer Kinetic Modelling and its use in PET Quantification 6. Principles of Radiological Protection in Healthcare 7. Controversies in Nuclear Medicine Dosimetry 8. Monte Carlo Simulation of Photon and Electron Transport in Matter 9. Patient Models for Dosimetry Applications 10. Patient-Specific Dosimetry Calculations 11. Whole Body Dosimetry 12. Personalized Dosimetry in Radioembolization 13. Thyroid Imaging and Dosimetry 14. Bone Marrow Dosimetry 15. Cellular and Multicellular Dosimetry 16. Alpha-Particle Dosimetry 17. Staff Radiation Protection 18. IAEA support to Nuclear Medicine Volume III: Radiopharmaceuticals and Clinical Applications. 1. Principles behind Radiopharmacy 2. Radiopharmaceuticals for diagnostics: Planar/SPECT 3. Radiopharmaceuticals for diagnostics: PET 4. Radiopharmaceuticals for radionuclide therapy 5. Design Considerations for a Radiopharmaceutical Production Facility 6. Methods and Equipment for Quality Control of Radiopharmaceuticals 7. Environmental Compliance and Control for Radiopharmaceutical Production: Commercial Manufacturing and Extemporaneous Preparation 8. GMP - rules and recommendations 9. Management of Radioactive Waste in Nuclear Medicine 10. Translation of Radiopharmaceuticals: Mouse to Man 11. Radionuclide Bone Scintigraphy 12. Radionuclide Examinations of the Kidneys 13. Neuroimaging in Nuclear Medicine 14. Methodology and Clinical Implementation of Ventilation/Perfusion Tomography for Diagnosis and Follow-up of Pulmonary Embolism and Other Pulmonary Diseases Clinical use of hybrid V/P SPECT-CT 15. Myocardiac Perfusion Imaging 16. Infection and Inflammation 17. Special Considerations In Pediatric Nuclear Medicine 19. Antibody-Based Radionuclide Imaging 18. Radionuclide-Based Diagnosis and Therapy of Prostate Cancer 20. Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors 21. Lymphoscintigraphy 22. Diagnostic Ultrasound Tomas Jansson23. Clinical Trials - Purpose and Procedures 24. Introduction to Patient Safety and Improvement Knowledge 25. Closing remarks