This book gives a nearly complete overview of the current state-of-the-art oligonucleotide drugs. … provides valuable insights into the great opportunities that are presented by this technology.—Dr. Kees Fluiter, The University of Amsterdam, in ChemMedChem, Vol. 4, 2009This edition is a cutting edge document including up-to-date cited references and a variety of compelling clinical case studies, and it of course retains the superb basic principles and background to antisense drug technologies featured in the first edition.—Gary Evans, Industrial Research Ltd., in Journal of Medicinal Chemistry, 2008, Vol. 51, No. 5

• Introduction, The Basics of Oligonucleotide-Based Therapeutics, Hybridization-Based Drugs: Basic Properties 2_-O-Methoxyethyl Oligonucleotides, Hybridization-Based Drugs: Basic Properties Duplex RNA Drugs, Other Chemical Classes of Drugs, Therapeutic Applications, Index