This book gives a nearly complete overview of the current state-of-the-art oligonucleotide drugs. ... provides valuable insights into the great opportunities that are presented by this technology. -Dr. Kees Fluiter, The University of Amsterdam, in ChemMedChem, Vol. 4, 2009 This edition is a cutting edge document including up-to-date cited references and a variety of compelling clinical case studies, and it of course retains the superb basic principles and background to antisense drug technologies featured in the first edition. -Gary Evans, Industrial Research Ltd., in Journal of Medicinal Chemistry, 2008, Vol. 51, No. 5

• Introduction, The Basics of Oligonucleotide-Based Therapeutics, Hybridization-Based Drugs: Basic Properties 2_-O-Methoxyethyl Oligonucleotides, Hybridization-Based Drugs: Basic Properties Duplex RNA Drugs, Other Chemical Classes of Drugs, Therapeutic Applications, Index