Mitochondrial Medicine

Volume 1: Targeting Mitochondria

AvVolkmar Weissig,Marvin Edeas

Inbunden, Engelska, 2021

Del i serien Methods in Molecular Biology

2 433 kr

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Beskrivning

This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume I guides readers through chapters on QSAR models, DQAsomes, synthesis of Triphenylphosphonium Phospholipid Conjugates, testing of novel isomeric mitochondriotropic derivatives, mTRIP, mitochondria-targeted imaging nanoplatforms, live-cell assessment, mitochondrial coenzyme Q10, rat liver Mitochondrial Lipidome, and Mito-SinCe2. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 1: Targeting Mitochondria aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.

Produktinformation

Utgivningsdatum:2021-06-13
Mått:178 x 254 x 31 mm
Vikt:1 085 g
Format:Inbunden
Språk:Engelska
Serie:Methods in Molecular Biology
Antal sidor:459
Upplaga:2
Förlag:Springer-Verlag New York Inc.
ISBN:9781071612613

Utforska kategorier

Patologi inom Medicin
Medicinsk utrustning och medicinska tekniker inom Medicin
Biologi inom Naturvetenskap och teknik

Innehållsförteckning

Using QSAR Models to Predict Mitochondrial Targeting by Small Molecule Xenobiotics within Living Cells.- DQAsomes as the Prototype of Mitochondria-targeted Pharmaceutical Nanocarriers: An Update.- Synthesis and Characterization of Mitochondria-Targeted Triphenyltriphenylphosphonium Bolaamphiphiles.- Synthesis and Evaluation of 18F-labeled Fluoroalkyl Triphenylphosphonium Salts as Mitochondrial Voltage Sensors in PET Myocardial Imaging.- Novel Mitochondria-Targeted Triphenylphosphonium Conjugates of Linear beta-Phosphorylated Nitrones: Preparation, 31P NMR Mitochondrial Distribution, EPR Spin Trapping Reporting, and Site-Directed Anti-Apoptotic Properties.- Insights on Targeting Small Molecules to the Mitochondrial Matrix and the Preparation of MitoB and MitoP as exomarkers of Mitochondrial Hydrogen Peroxide.- Synthesis of Triphenylphosphonium Phospholipid Conjugates for the Preparation of Mitochondriotropic Liposomes.- Imaging Mitochondrial Hydrogen Peroxide in Living Cells.- Synthesis and Testing Of Novel Isomeric Mitochondriotropic Derivatives of Resveratrol and Quercetin.- Bridging the Gap between Nature and Antioxidant Setbacks: Delivering Gallic Acid to Mitochondria.- Liposomal Delivery of Cyclocreatine Impairs Cancer Cell Bioenergetics Mediating Apoptosis.- Mt-fura-2, a ratiometric Mitochondria-targeted Ca2+ sensor. Determination of spectroscopic properties and Ca2+ Imaging Assays.- Sequence-Specific Control of Mitochondrial Gene Transcription using Programmable Synthetic Gene Switches called MITO-PIPs.- Targeting the Mitochondrial Genome via a MITO-Porter: Evaluation of mtDNA and mtRNA Levels and Mitochondrial Function.- mTRIP, an Imaging Tool to Investigate Mitochondrial DNA dynamics in Physiology and Disease at the Single-Cell Resolution.- Development of Mitochondria-Targeted Imaging Nanoplatforms by Incorporation of Fluorescent Carbon Quantum Dots.- Norbormide-based Probes and their Application for Mitochondrial Imaging in Drosophila Melanogaster.- Live-cell Assessment of Reactive Oxygen Species Levels Using Dihydroethidine.- Protein Supercomplex Recording In Living Cells Via Position-Specific Fluorescence Lifetime Sensors.- Identification of Peroxynitrite by Profiling Oxidation and Nitration Products from Mitochondria-Targeted Arylboronic Acid.- Mitochondrial Coenzyme Q10 Determination via Isotope Dilution Liquid Chromatography Tandem Mass Spectrometry.- Janus-type Mesoporous Silica Nanoparticles for Sequential Tumoral Cell and Mitochondria Targeting.- Split Green Fluorescent Protein-Based Contact Site Sensor (SPLICS) for Heterotypic Organelle Juxtaposition as Applied to ER – Mitochondria Proximities.- Qualitative Characterization of the Rat liver Mitochondrial Lipidome using All Ion Fragmentation on an Exactive Benchtop Orbitrap MS.- Live Imaging of Mitochondria in Kidney Tissue.- Time-resolved Imaging of Mitochondrial Flavin Fluorescence and Its Applications for Evaluating the Oxidative State in Living Cardiac Cells.- Mito-SinCe2 Approach to Analyze Mitochondrial Structure-Function In Single Cells.- Computer-aided Prediction of Protein Mitochondrial Localization.