Cancer Cytogenetics and Cytogenomics

Methods and Protocols

AvJing Christine Ye,Henry H. Heng

Inbunden, Engelska, 2024

Del 2825 i serien Methods in Molecular Biology

1 963 kr

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Beskrivning

This detailed volume explores the frontiers of this new era in cancer cytogenetics and cytogenomics, focusing on establishing a karyotype as an information-based genomic framework, as well as presenting technological platforms for collecting and analyzing data at the genome level.

Produktinformation

Utgivningsdatum:2024-06-25
Mått:178 x 254 x 28 mm
Vikt:969 g
Format:Inbunden
Språk:Engelska
Serie:Methods in Molecular Biology
Antal sidor:397
Upplaga:2024
Förlag:Springer-Verlag New York Inc.
ISBN:9781071639450

Utforska kategorier

Onkologi inom Medicin
Cellbiologi inom Naturvetenskap och teknik
Biovetenskap inom Naturvetenskap och teknik

Innehållsförteckning

The New Era of Cancer Cytogenetics and Cytogenomics.- Methods of Detection and Mechanisms of Origin of Complex Structural Genome Variations.- A Paradoxical Role for Somatic Chromosomal Mosaicism and Chromosome Instability in Cancer: Theoretical and Technological Aspects.- The Importance of Monitoring Non-Clonal Chromosome Aberrations (NCCAs) in Cancer Research.- Optical Genome Mapping: A Case Study for Machine-Based Platforms in Cytogenetics and Cytogenomics.- Cell Culture and Slide Preparation for Cytogenetic Studies of Hematological Neoplasms.- Chromosome Bandings and Recognition.- Cancer Sample Analysis Utilizing Single-Nucleotide Polymorphism Array and Array Comparative Genomic Hybridization.- Multitarget Fluorescence In Situ Hybridization Diagnostic Applications in Tumors.- High-Resolution FISH Analysis Using DNA Fibers Generated by Molecular Combing.- FISH-Banding for Characterization of Simple and Complex Chromosomal Rearrangements in Cancer.- Profiling Chromosome Topological Features by Super-Resolution 3D Structured Illumination Microscopy.- Quantitative FISHing: Implications for Chromosomal Analysis.- Characterizing Chemotherapy/Radiotherapy-Induced Genome Chaos in Hodgkin’s Lymphoma Patients Using M-FISH.- Tracking Karyotype Changes in Treatment-Induced Drug-Resistant Evolution.- Generation of Polyploid Giant Cancer Cells (PGCCs) from Hey Ovarian Cancer Cells and Analysis of Embryonic Properties.- Single-Cell MTT: A Simple and Sensitive Assay for Determining the Viability and Metabolic Activity of Polyploid Giant Cancer Cells (PGCCs).- Evaluating Chromosome Instability and Genotoxicity Through Single-Cell Quantitative Imaging Microscopy.- Studying the Dynamics of Tunneling Tubes and Cellular Spheres.- Profiling Numerical and Structural Chromosomal Instability in Different Cancer Types.- The Digital World of Cytogenetic and Cytogenomic Web Resources.