ZBIGNIEW J. WITCZAK, PhD, is Professor in the Department of Pharmaceutical Sciences of the Nesbitt School of Pharmacy at Wilkes University. He has published over ninety research papers and holds six patents. His research focuses on carbohydrate synthons, including levoglucosenone and L-arabinose, as templates for carbohydrate-based therapeutics. In 2000, Dr. Witczak was awarded the Melville L. Wolfrom Award from the ACS Division of Carbohydrate Chemistry.ROMAN BIELSKI, PhD, is Senior Scientist at Value Recovery, Inc., Partner in Cheminnolab, LLC, and Adjunct Professor in the Department of Pharmaceutical Sciences at Wilkes University. His research investigates the origin of homochirality, modification of carbohydrates, solutions to environmental issues, and sustainability. As part of his achievements, Dr. Bielski co-developed a method of enantiomers' resolution, which might have been involved in prebiotic homochirality, since it would not require the use of chiral compounds.

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• FOREWORD viiPREFACE ixCONTRIBUTORS xiiiLIST OF ABBREVIATIONS xviiI CLICK CHEMISTRY STRATEGIES AND DECOUPLING1 Paradigm and Advantage of Carbohydrate Click Chemistry Strategy for Future Decoupling 3Roman Bielski and Zbigniew J. WitczakII THIO-CLICK CHEMISTRY OF CARBOHYDRATES2 Thio-Click Chemistry in Glycoscience: Overview and Perspectives 33Zbigniew J. Witczak3 Free-Radical Thiol-ene and Thiol-yne Couplings as Click Processes for Glycoconjugation 45Alessandro Dondoni and Alberto MarraIII CARBOHYDRATE CLICK CHEMISTRY FOR NOVEL SYNTHETIC TARGETS4 The Development and Application of Clickable Lipid Analogs for Elucidating and Harnessing Lipid Functions 79Michael D. Best5 Clicking Sugars onto Sugars: Oligosaccharide Analogs and Glycoclusters on Carbohydrate Scaffolds 107Maria Laura Uhrig and Jos´e Kovensky6 Click Multivalent Glycomaterials: Glycoclusters, Glycodendrimers, Glycopolymers, Hybrid Glycomaterials, and Glycosurfaces 143Carmen Ortiz Mellet, Alejandro M´endez-Ardoy, and Jos´e Manuel Garc´©¥a Fern´andez7 Toward Imaging Glycotools by Click Coupling 183Yves Chapleur, Christine Vala, Franc¸oise Chr´etien, and Sandrine Lamand´e-Langle8 Bioorthogonal Reactions for Labeling Glycoconjugates 211Fr´ed´eric Friscourt and Geert-Jan Boons9 “Sweet” Sucrose Macrocycles via a “Click Chemistry” Route 235Mykhaylo A. Potopnyk and S©©awomir JaroszIV CARBOHYDRATE CLICK CHEMISTRY IN BIOMEDICAL SCIENCES10 Neoglycoprotein Synthesis Using the Copper-Catalyzed Azide–Alkyne Click Reaction and Native Chemical Ligation 253Joanna M. Wojnar, Dong Jun Lee, Clive W. Evans, Kalyaneswar Mandal, Stephen B. H. Kent, and Margaret A. Brimble11 Biomedical Applications of “Click”-Modified Cyclodextrins 271Zhenshan Jia, Rakesh K. Singh, and Dong Wang12 Triazolyl Glycoconjugates in Medicinal Chemistry 293Rama Pati Tripathi, Pratibha Dwivedi, Anindra Sharma, Divya Kushwaha, and Vinod Kumar Tiwari13 Click Chemistry Applied to Carbohydrate-Based Drug Discovery 325Vanessa Leiria Campo and Ivone CarvalhoINDEX 359

ZBIGNIEW J. WITCZAK, PhD, is Professor in the Department of Pharmaceutical Sciences of the Nesbitt School of Pharmacy at Wilkes University. He has published over ninety research papers and holds six patents. His research focuses on carbohydrate synthons, including levoglucosenone and L-arabinose, as templates for carbohydrate-based therapeutics. In 2000, Dr. Witczak was awarded the Melville L. Wolfrom Award from the ACS Division of Carbohydrate Chemistry.ROMAN BIELSKI, PhD, is Senior Scientist at Value Recovery, Inc., Partner in Cheminnolab, LLC, and Adjunct Professor in the Department of Pharmaceutical Sciences at Wilkes University. His research investigates the origin of homochirality, modification of carbohydrates, solutions to environmental issues, and sustainability. As part of his achievements, Dr. Bielski co-developed a method of enantiomers' resolution, which might have been involved in prebiotic homochirality, since it would not require the use of chiral compounds.

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• FOREWORD viiPREFACE ixCONTRIBUTORS xiiiLIST OF ABBREVIATIONS xviiI CLICK CHEMISTRY STRATEGIES AND DECOUPLING1 Paradigm and Advantage of Carbohydrate Click Chemistry Strategy for Future Decoupling 3Roman Bielski and Zbigniew J. WitczakII THIO-CLICK CHEMISTRY OF CARBOHYDRATES2 Thio-Click Chemistry in Glycoscience: Overview and Perspectives 33Zbigniew J. Witczak3 Free-Radical Thiol-ene and Thiol-yne Couplings as Click Processes for Glycoconjugation 45Alessandro Dondoni and Alberto MarraIII CARBOHYDRATE CLICK CHEMISTRY FOR NOVEL SYNTHETIC TARGETS4 The Development and Application of Clickable Lipid Analogs for Elucidating and Harnessing Lipid Functions 79Michael D. Best5 Clicking Sugars onto Sugars: Oligosaccharide Analogs and Glycoclusters on Carbohydrate Scaffolds 107Maria Laura Uhrig and Jos´e Kovensky6 Click Multivalent Glycomaterials: Glycoclusters, Glycodendrimers, Glycopolymers, Hybrid Glycomaterials, and Glycosurfaces 143Carmen Ortiz Mellet, Alejandro M´endez-Ardoy, and Jos´e Manuel Garc´©¥a Fern´andez7 Toward Imaging Glycotools by Click Coupling 183Yves Chapleur, Christine Vala, Franc¸oise Chr´etien, and Sandrine Lamand´e-Langle8 Bioorthogonal Reactions for Labeling Glycoconjugates 211Fr´ed´eric Friscourt and Geert-Jan Boons9 “Sweet” Sucrose Macrocycles via a “Click Chemistry” Route 235Mykhaylo A. Potopnyk and S©©awomir JaroszIV CARBOHYDRATE CLICK CHEMISTRY IN BIOMEDICAL SCIENCES10 Neoglycoprotein Synthesis Using the Copper-Catalyzed Azide–Alkyne Click Reaction and Native Chemical Ligation 253Joanna M. Wojnar, Dong Jun Lee, Clive W. Evans, Kalyaneswar Mandal, Stephen B. H. Kent, and Margaret A. Brimble11 Biomedical Applications of “Click”-Modified Cyclodextrins 271Zhenshan Jia, Rakesh K. Singh, and Dong Wang12 Triazolyl Glycoconjugates in Medicinal Chemistry 293Rama Pati Tripathi, Pratibha Dwivedi, Anindra Sharma, Divya Kushwaha, and Vinod Kumar Tiwari13 Click Chemistry Applied to Carbohydrate-Based Drug Discovery 325Vanessa Leiria Campo and Ivone CarvalhoINDEX 359

ZBIGNIEW J. WITCZAK, PhD, is Professor in the Department of Pharmaceutical Sciences of the Nesbitt School of Pharmacy at Wilkes University. He has published over ninety research papers and holds six patents. His research focuses on carbohydrate synthons, including levoglucosenone and L-arabinose, as templates for carbohydrate-based therapeutics. In 2000, Dr. Witczak was awarded the Melville L. Wolfrom Award from the ACS Division of Carbohydrate Chemistry.ROMAN BIELSKI, PhD, is Senior Scientist at Value Recovery, Inc., Partner in Cheminnolab, LLC, and Adjunct Professor in the Department of Pharmaceutical Sciences at Wilkes University. His research investigates the origin of homochirality, modification of carbohydrates, solutions to environmental issues, and sustainability. As part of his achievements, Dr. Bielski co-developed a method of enantiomers' resolution, which might have been involved in prebiotic homochirality, since it would not require the use of chiral compounds.

Select Guide Rating

• FOREWORD viiPREFACE ixCONTRIBUTORS xiiiLIST OF ABBREVIATIONS xviiI CLICK CHEMISTRY STRATEGIES AND DECOUPLING1 Paradigm and Advantage of Carbohydrate Click Chemistry Strategy for Future Decoupling 3Roman Bielski and Zbigniew J. WitczakII THIO-CLICK CHEMISTRY OF CARBOHYDRATES2 Thio-Click Chemistry in Glycoscience: Overview and Perspectives 33Zbigniew J. Witczak3 Free-Radical Thiol-ene and Thiol-yne Couplings as Click Processes for Glycoconjugation 45Alessandro Dondoni and Alberto MarraIII CARBOHYDRATE CLICK CHEMISTRY FOR NOVEL SYNTHETIC TARGETS4 The Development and Application of Clickable Lipid Analogs for Elucidating and Harnessing Lipid Functions 79Michael D. Best5 Clicking Sugars onto Sugars: Oligosaccharide Analogs and Glycoclusters on Carbohydrate Scaffolds 107Maria Laura Uhrig and Jos´e Kovensky6 Click Multivalent Glycomaterials: Glycoclusters, Glycodendrimers, Glycopolymers, Hybrid Glycomaterials, and Glycosurfaces 143Carmen Ortiz Mellet, Alejandro M´endez-Ardoy, and Jos´e Manuel Garc´©¥a Fern´andez7 Toward Imaging Glycotools by Click Coupling 183Yves Chapleur, Christine Vala, Franc¸oise Chr´etien, and Sandrine Lamand´e-Langle8 Bioorthogonal Reactions for Labeling Glycoconjugates 211Fr´ed´eric Friscourt and Geert-Jan Boons9 “Sweet” Sucrose Macrocycles via a “Click Chemistry” Route 235Mykhaylo A. Potopnyk and S©©awomir JaroszIV CARBOHYDRATE CLICK CHEMISTRY IN BIOMEDICAL SCIENCES10 Neoglycoprotein Synthesis Using the Copper-Catalyzed Azide–Alkyne Click Reaction and Native Chemical Ligation 253Joanna M. Wojnar, Dong Jun Lee, Clive W. Evans, Kalyaneswar Mandal, Stephen B. H. Kent, and Margaret A. Brimble11 Biomedical Applications of “Click”-Modified Cyclodextrins 271Zhenshan Jia, Rakesh K. Singh, and Dong Wang12 Triazolyl Glycoconjugates in Medicinal Chemistry 293Rama Pati Tripathi, Pratibha Dwivedi, Anindra Sharma, Divya Kushwaha, and Vinod Kumar Tiwari13 Click Chemistry Applied to Carbohydrate-Based Drug Discovery 325Vanessa Leiria Campo and Ivone CarvalhoINDEX 359