Click Chemistry in Glycoscience

New Developments and Strategies

Inbunden, Engelska, 2013

1 514 kr

Beställningsvara. Skickas inom 7-10 vardagar. Fri frakt över 249 kr.

Beskrivning

Lays the foundation for new methods and applications of carbohydrate click chemistryIntroduced by K. Barry Sharpless of The Scripps Research Institute in 2001, click chemistry mimics nature, giving researchers the tools needed to generate new substances quickly and reliably by joining small units together. With contributions from more than thirty pioneering researchers in the field, this text explores the many promising applications of click chemistry in glycoscience. Readers will learn both the basic concepts of carbohydrate click chemistry as well as its many biomedical applications, including synthetic antigens, analogs of cell-surface receptors, immobilized enzymes, targeted drug delivery systems, and multivalent cancer vaccines.Click Chemistry in Glycoscience examines a broad range of methodologies and strategies that have emerged from this rapidly evolving field. Each chapter describes new approaches, ideas, consequences, and applications resulting from the introduction of click processes. Divided into four sections, the book covers: Click chemistry strategies and decouplingThio-click chemistry of carbohydratesCarbohydrate click chemistry for novel synthetic targetsCarbohydrate click chemistry in biomedical sciencesThoroughly researched, the book reflects the most recent findings published in the literature. Diagrams and figures throughout the book enable readers to more easily grasp complex concepts and reaction processes. At the end of each chapter, references lead to the primary literature for further investigation of individual topics.The application of click chemistry to carbohydrates has tremendous implications for research. With this book as their guide, researchers have a solid foundation from which they can develop new methods and applications of carbohydrate click chemistry, including new carbohydrate-based therapeutics.

Produktinformation

Utgivningsdatum:2013-04-12
Mått:160 x 236 x 31 mm
Vikt:771 g
Format:Inbunden
Språk:Engelska
Antal sidor:400
Förlag:John Wiley & Sons Inc
Medarbetare:Horton,Derek
ISBN:9781118275337

Utforska kategorier

Biokemi inom Naturvetenskap och teknik

Mer om författaren

ZBIGNIEW J. WITCZAK, PhD, is Professor in the Department of Pharmaceutical Sciences of the Nesbitt School of Pharmacy at Wilkes University. He has published over ninety research papers and holds six patents. His research focuses on carbohydrate synthons, including levoglucosenone and L-arabinose, as templates for carbohydrate-based therapeutics. In 2000, Dr. Witczak was awarded the Melville L. Wolfrom Award from the ACS Division of Carbohydrate Chemistry.ROMAN BIELSKI, PhD, is Senior Scientist at Value Recovery, Inc., Partner in Cheminnolab, LLC, and Adjunct Professor in the Department of Pharmaceutical Sciences at Wilkes University. His research investigates the origin of homochirality, modification of carbohydrates, solutions to environmental issues, and sustainability. As part of his achievements, Dr. Bielski co-developed a method of enantiomers' resolution, which might have been involved in prebiotic homochirality, since it would not require the use of chiral compounds.

Innehållsförteckning

FOREWORD viiPREFACE ixCONTRIBUTORS xiiiLIST OF ABBREVIATIONS xviiI CLICK CHEMISTRY STRATEGIES AND DECOUPLING1 Paradigm and Advantage of Carbohydrate Click Chemistry Strategy for Future Decoupling 3Roman Bielski and Zbigniew J. WitczakII THIO-CLICK CHEMISTRY OF CARBOHYDRATES2 Thio-Click Chemistry in Glycoscience: Overview and Perspectives 33Zbigniew J. Witczak3 Free-Radical Thiol-ene and Thiol-yne Couplings as Click Processes for Glycoconjugation 45Alessandro Dondoni and Alberto MarraIII CARBOHYDRATE CLICK CHEMISTRY FOR NOVEL SYNTHETIC TARGETS4 The Development and Application of Clickable Lipid Analogs for Elucidating and Harnessing Lipid Functions 79Michael D. Best5 Clicking Sugars onto Sugars: Oligosaccharide Analogs and Glycoclusters on Carbohydrate Scaffolds 107Maria Laura Uhrig and Jos´e Kovensky6 Click Multivalent Glycomaterials: Glycoclusters, Glycodendrimers, Glycopolymers, Hybrid Glycomaterials, and Glycosurfaces 143Carmen Ortiz Mellet, Alejandro M´endez-Ardoy, and Jos´e Manuel Garc´©¥a Fern´andez7 Toward Imaging Glycotools by Click Coupling 183Yves Chapleur, Christine Vala, Franc¸oise Chr´etien, and Sandrine Lamand´e-Langle8 Bioorthogonal Reactions for Labeling Glycoconjugates 211Fr´ed´eric Friscourt and Geert-Jan Boons9 “Sweet” Sucrose Macrocycles via a “Click Chemistry” Route 235Mykhaylo A. Potopnyk and S©©awomir JaroszIV CARBOHYDRATE CLICK CHEMISTRY IN BIOMEDICAL SCIENCES10 Neoglycoprotein Synthesis Using the Copper-Catalyzed Azide–Alkyne Click Reaction and Native Chemical Ligation 253Joanna M. Wojnar, Dong Jun Lee, Clive W. Evans, Kalyaneswar Mandal, Stephen B. H. Kent, and Margaret A. Brimble11 Biomedical Applications of “Click”-Modified Cyclodextrins 271Zhenshan Jia, Rakesh K. Singh, and Dong Wang12 Triazolyl Glycoconjugates in Medicinal Chemistry 293Rama Pati Tripathi, Pratibha Dwivedi, Anindra Sharma, Divya Kushwaha, and Vinod Kumar Tiwari13 Click Chemistry Applied to Carbohydrate-Based Drug Discovery 325Vanessa Leiria Campo and Ivone CarvalhoINDEX 359