Dr Luis M Botana is Director of the Community Reference Laboratory for Marine Toxins and Head of the Department of Pharmacology, University of Santiago de Compostela, Spain.Dr Amparo Alfonso is Professor of Pharmacology, University of Santiago de Compostela, Spain.

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• List of contributors viiPreface xiii1 Analysis of marine toxins: gaps on food safety control of marine toxins 1Paz Otero and Carmen Alfonso2 Pharmacology of ciguatoxins 23Carmen Vale, Álvaro Antelo and Víctor Martín3 Chemistry of pinnatoxins 49Phillip Mabe and Armen Zakarian4 Chemistry and analysis of PSP toxins 69Ana Botana and Verónica Rey López5 Chemistry of palytoxin and its analogues 85Patrizia Ciminiello, Carmela Dell’Aversano and Martino Forino6 Pharmacology of palytoxins and ostreocins 113M. Carmen Louzao, María Fraga and Natalia Vilarin˜ o7 Recent insights into anatoxin-a chemical synthesis, biomolecular targets, mechanisms of action and LC-MS detection 137Custódia Fonseca, Manuel Aureliano, Feras Abbas and Ambrose Furey8 Therapeutics of marine toxins 181Eva Alonso and Juan A. Rubiolo9 Marine toxins as modulators of apoptosis 203Amparo Alfonso, Andrea Fernández-Araujo and Mercedes R. Vieytes10 Cyanobacterial toxins 225Vitor Vasconcelos, Pedro Leão and Alexandre Campos11 Marine toxins and climate change: the case of PSP from cyanobacteria in coastal lagoons 239Antonella Lugliè, Silvia Pulina, Milena Bruno, Bachisio Mario Padedda, Cecilia Teodora Satta, and Nicola Sechi12 Microalgae as a source of nutraceuticals 255Sushanta Kumar Saha, Edward McHugh, Patrick Murray and Daniel J. Walsh13 The marine origin of drugs 293André Horta, Celso Alves, Susete Pinteus and Rui Pedrosa14 Pharmacology of cylindrospermopsin 317Juan A. Rubiolo, Diego Alberto Fernández, Henar López and M. Carmen Louzao15 Pharmacology of the cyclic imines 343Natalia Vilarinõ, Sara F. Ferreiro, Andrés Crespo and José Gil16 Diversity of organic structures of marine microbial origin with drug potential 361Marcel Jaspars, Rainer Ebel and Hai Deng17 Polyketides as a source of chemical diversity 381Tanya Beletskaya, Catherine Collins and Patrick Murray18 Ichthyotoxins 407John W. La Claire II and Schonna R. Manning19 Pathological clues of phycotoxin ingestion 463Manuel Cifuentes, Andrés Crespo and Roberto BermúdezIndex 513

Dr Luis M Botana is Director of the Community Reference Laboratory for Marine Toxins and Head of the Department of Pharmacology, University of Santiago de Compostela, Spain.Dr Amparo Alfonso is Professor of Pharmacology, University of Santiago de Compostela, Spain.

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• List of contributors viiPreface xiii1 Analysis of marine toxins: gaps on food safety control of marine toxins 1Paz Otero and Carmen Alfonso2 Pharmacology of ciguatoxins 23Carmen Vale, Álvaro Antelo and Víctor Martín3 Chemistry of pinnatoxins 49Phillip Mabe and Armen Zakarian4 Chemistry and analysis of PSP toxins 69Ana Botana and Verónica Rey López5 Chemistry of palytoxin and its analogues 85Patrizia Ciminiello, Carmela Dell’Aversano and Martino Forino6 Pharmacology of palytoxins and ostreocins 113M. Carmen Louzao, María Fraga and Natalia Vilarin˜ o7 Recent insights into anatoxin-a chemical synthesis, biomolecular targets, mechanisms of action and LC-MS detection 137Custódia Fonseca, Manuel Aureliano, Feras Abbas and Ambrose Furey8 Therapeutics of marine toxins 181Eva Alonso and Juan A. Rubiolo9 Marine toxins as modulators of apoptosis 203Amparo Alfonso, Andrea Fernández-Araujo and Mercedes R. Vieytes10 Cyanobacterial toxins 225Vitor Vasconcelos, Pedro Leão and Alexandre Campos11 Marine toxins and climate change: the case of PSP from cyanobacteria in coastal lagoons 239Antonella Lugliè, Silvia Pulina, Milena Bruno, Bachisio Mario Padedda, Cecilia Teodora Satta, and Nicola Sechi12 Microalgae as a source of nutraceuticals 255Sushanta Kumar Saha, Edward McHugh, Patrick Murray and Daniel J. Walsh13 The marine origin of drugs 293André Horta, Celso Alves, Susete Pinteus and Rui Pedrosa14 Pharmacology of cylindrospermopsin 317Juan A. Rubiolo, Diego Alberto Fernández, Henar López and M. Carmen Louzao15 Pharmacology of the cyclic imines 343Natalia Vilarinõ, Sara F. Ferreiro, Andrés Crespo and José Gil16 Diversity of organic structures of marine microbial origin with drug potential 361Marcel Jaspars, Rainer Ebel and Hai Deng17 Polyketides as a source of chemical diversity 381Tanya Beletskaya, Catherine Collins and Patrick Murray18 Ichthyotoxins 407John W. La Claire II and Schonna R. Manning19 Pathological clues of phycotoxin ingestion 463Manuel Cifuentes, Andrés Crespo and Roberto BermúdezIndex 513

Dr Luis M Botana is Director of the Community Reference Laboratory for Marine Toxins and Head of the Department of Pharmacology, University of Santiago de Compostela, Spain.Dr Amparo Alfonso is Professor of Pharmacology, University of Santiago de Compostela, Spain.

Select Guide Rating

• List of contributors viiPreface xiii1 Analysis of marine toxins: gaps on food safety control of marine toxins 1Paz Otero and Carmen Alfonso2 Pharmacology of ciguatoxins 23Carmen Vale, Álvaro Antelo and Víctor Martín3 Chemistry of pinnatoxins 49Phillip Mabe and Armen Zakarian4 Chemistry and analysis of PSP toxins 69Ana Botana and Verónica Rey López5 Chemistry of palytoxin and its analogues 85Patrizia Ciminiello, Carmela Dell’Aversano and Martino Forino6 Pharmacology of palytoxins and ostreocins 113M. Carmen Louzao, María Fraga and Natalia Vilarin˜ o7 Recent insights into anatoxin-a chemical synthesis, biomolecular targets, mechanisms of action and LC-MS detection 137Custódia Fonseca, Manuel Aureliano, Feras Abbas and Ambrose Furey8 Therapeutics of marine toxins 181Eva Alonso and Juan A. Rubiolo9 Marine toxins as modulators of apoptosis 203Amparo Alfonso, Andrea Fernández-Araujo and Mercedes R. Vieytes10 Cyanobacterial toxins 225Vitor Vasconcelos, Pedro Leão and Alexandre Campos11 Marine toxins and climate change: the case of PSP from cyanobacteria in coastal lagoons 239Antonella Lugliè, Silvia Pulina, Milena Bruno, Bachisio Mario Padedda, Cecilia Teodora Satta, and Nicola Sechi12 Microalgae as a source of nutraceuticals 255Sushanta Kumar Saha, Edward McHugh, Patrick Murray and Daniel J. Walsh13 The marine origin of drugs 293André Horta, Celso Alves, Susete Pinteus and Rui Pedrosa14 Pharmacology of cylindrospermopsin 317Juan A. Rubiolo, Diego Alberto Fernández, Henar López and M. Carmen Louzao15 Pharmacology of the cyclic imines 343Natalia Vilarinõ, Sara F. Ferreiro, Andrés Crespo and José Gil16 Diversity of organic structures of marine microbial origin with drug potential 361Marcel Jaspars, Rainer Ebel and Hai Deng17 Polyketides as a source of chemical diversity 381Tanya Beletskaya, Catherine Collins and Patrick Murray18 Ichthyotoxins 407John W. La Claire II and Schonna R. Manning19 Pathological clues of phycotoxin ingestion 463Manuel Cifuentes, Andrés Crespo and Roberto BermúdezIndex 513