Alan R. Templeton, PhD, is Charles Rebstock Professor Emeritus of Biology and Statistical Genomics at Washington University in St. Louis. His research focus is on the application of molecular genetic techniques and statistical population genetics to a variety of basic and applied evolutionary problems. He is on the editorial boards of Molecular Phylogenetics and Evolution and Evolutionary Bioinformatics Online.

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• Preface to the 2nd Edition    ixChapter 1.  The Scope and Basic Premises of Population Genetics  1-1Basic Premises of Population Genetics  1-1Population Genomics1-12Section 1:  Population Structure and HistoryChapter 2.  Modeling Evolution and the Hardy-Weinberg Law  2-1How to Model Microevolution  2-1The Hardy-Weinberg Model  2-4Hardy-Weinberg for Two Loci2-19Chapter 3.  Systems of Mating  3-1Inbreeding  3-1Assortative Mating3-25Disassortative Mating3-45Chapter 4.  Genetic Drift  4-1Basic Evolutionary Properties of Genetic Drift  4-2Founder and Bottleneck Effects  4-7Genetic Drift and Disequilibrium4-11Genetic Drfit, Disequilibrium, and System of Mating4-13Effective Population Size4-18Chapter 5.  Genetic Drift in Large Populations and Coalescence  5-1Newly Arisen Mutations  5-1Neutral Alleles  5-3The Coalescent5-22Chapter 6.  Gene Flow and Population Subdivision  6-1Gene Flow Between Two Local Populations  6-1The Balance of Gene Flow and Drift  6-6An Example of the Balance of Drift and Gene Flow6-27Factors Influencing The Amount and Patter of Gene Flow6-42Total Effective Population Size in Subdivided Populations6-62Multiple Modes of Inheritance and Population Structure6-71Admixture6-76Identifying Subpopulations and Population Structure6-81A Final Warning6-96Chapter 7.  Population History  7-1Inferring Historical Effective Population Sizes  7-6Inferring Historical Gene Flow Patterns and Admixture 7-11Using Haplotype Trees to Study Population History 7-19Model Based Approaches to Phylogeographic Analysis 7-56Direct Studies Over Space and Past Times 7-70Historical Population Genetics and Macroevolution 7-75Section 2:  Genotype and PhenotypeChapter 8.  Basic Quantitative Genetic Definitions and Theory  8-1“Simple” Mendelian Phenotypes  8-2Nature Versus Nurture?  8-7The Fisherian Model of Quantitative Genetics8-13Chapter 9.  Quantitative Genetics:  Unmeasured Genotypes  9-1Correlation Between Relatives  9-2The Distinction Between Heritability and Inheritance9-17Response to Selection9-19The Problem of Between-Population Differences in MeanPhenotype 9-21Controlled Crosses for the Analysis of Between PopulationDifferences 9-30The Balance Between Mutation, Drift, and Gene Flow UponPhenotypic Variance 9-36Chapter 10.  Quantitative Genetics:  Measured Genotypes  10-1Marker Association Studies  10-5Candidate Loci10-35Candidate Loci and Genetic Architecture10-51Section 3:  Natural Selection and AdaptationChapter 11.  Natural Selection  11-1The Fundamental Equation of Natural Selection:  MeasuredGenotypes  11-4Sickle-Cell Anemia as an Example of Natural Selection 11-10Adaptation as a Polygenic Process 11-24The Fundamental Theorem of Natural Selection:  UnmeasuredGenotypes  11-29Some Implications of the Fundamental Equations of NaturalSelection 11-33The Course of Adaptation and Natural Selection 11-47Chapter 12.  Interactions of Natural Selection with Other Evolutionary Forcesand the Detection of Natural Selection      12-1The Interaction of Natural Selection with Mutation   12-3The Interaction of Natural Selection with Mutation and System ofMating   12-8The Interaction of Natural Selection with Gene Flow 12-12The Interaction of Natural Selection with Genetic Drift 12-21The Interactions of Natural Selection, Genetic Drift, andGene Flow 12-28The Interactions of Natural Selection, Genetic Drift, and Mutation 12-45The Interactions of Natural Selection, Genetic Drift, Mutation, andRecombination 12-65Candidate Loci 12-71Quantitative Genetic Approaches to Detecting Selection 12-75The Neutralist/Selectionist Debate 12-80Chapter 13.  Units and Targets of Selection   13-1The Unit of Selection   13-4Targets of Selection Below the Level of the Individual 13-18Targets of Selection Above the Level of the Individual 13-51Chapter 14.  Selection in Heterogeneous Environments   14-1Coarse-Grained Spatial Heterogeneity   14-4Coarse-Grained Temporal Heterogeneity 14-34Fine-Grained Heterogeneity 14-56Coevolution 14-74Chapter 15.  Selection in Age-Structured Populations   15-1Life History and Fitness   15-3The Evolution of Senescence  15-13Abnormal Abdomen:  An Example of Selection in anAge-Structured Population  15-24Overview  15-63AppendicesAppendix 1.  Genetic Survey Techniques   A1-1Appendix 2.  Probability and Statistics   A2-1References     R-1Index

Alan R. Templeton, PhD, is Charles Rebstock Professor Emeritus of Biology and Statistical Genomics at Washington University in St. Louis. His research focus is on the application of molecular genetic techniques and statistical population genetics to a variety of basic and applied evolutionary problems. He is on the editorial boards of Molecular Phylogenetics and Evolution and Evolutionary Bioinformatics Online.

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• Preface to the 2nd Edition    ixChapter 1.  The Scope and Basic Premises of Population Genetics  1-1Basic Premises of Population Genetics  1-1Population Genomics1-12Section 1:  Population Structure and HistoryChapter 2.  Modeling Evolution and the Hardy-Weinberg Law  2-1How to Model Microevolution  2-1The Hardy-Weinberg Model  2-4Hardy-Weinberg for Two Loci2-19Chapter 3.  Systems of Mating  3-1Inbreeding  3-1Assortative Mating3-25Disassortative Mating3-45Chapter 4.  Genetic Drift  4-1Basic Evolutionary Properties of Genetic Drift  4-2Founder and Bottleneck Effects  4-7Genetic Drift and Disequilibrium4-11Genetic Drfit, Disequilibrium, and System of Mating4-13Effective Population Size4-18Chapter 5.  Genetic Drift in Large Populations and Coalescence  5-1Newly Arisen Mutations  5-1Neutral Alleles  5-3The Coalescent5-22Chapter 6.  Gene Flow and Population Subdivision  6-1Gene Flow Between Two Local Populations  6-1The Balance of Gene Flow and Drift  6-6An Example of the Balance of Drift and Gene Flow6-27Factors Influencing The Amount and Patter of Gene Flow6-42Total Effective Population Size in Subdivided Populations6-62Multiple Modes of Inheritance and Population Structure6-71Admixture6-76Identifying Subpopulations and Population Structure6-81A Final Warning6-96Chapter 7.  Population History  7-1Inferring Historical Effective Population Sizes  7-6Inferring Historical Gene Flow Patterns and Admixture 7-11Using Haplotype Trees to Study Population History 7-19Model Based Approaches to Phylogeographic Analysis 7-56Direct Studies Over Space and Past Times 7-70Historical Population Genetics and Macroevolution 7-75Section 2:  Genotype and PhenotypeChapter 8.  Basic Quantitative Genetic Definitions and Theory  8-1“Simple” Mendelian Phenotypes  8-2Nature Versus Nurture?  8-7The Fisherian Model of Quantitative Genetics8-13Chapter 9.  Quantitative Genetics:  Unmeasured Genotypes  9-1Correlation Between Relatives  9-2The Distinction Between Heritability and Inheritance9-17Response to Selection9-19The Problem of Between-Population Differences in MeanPhenotype 9-21Controlled Crosses for the Analysis of Between PopulationDifferences 9-30The Balance Between Mutation, Drift, and Gene Flow UponPhenotypic Variance 9-36Chapter 10.  Quantitative Genetics:  Measured Genotypes  10-1Marker Association Studies  10-5Candidate Loci10-35Candidate Loci and Genetic Architecture10-51Section 3:  Natural Selection and AdaptationChapter 11.  Natural Selection  11-1The Fundamental Equation of Natural Selection:  MeasuredGenotypes  11-4Sickle-Cell Anemia as an Example of Natural Selection 11-10Adaptation as a Polygenic Process 11-24The Fundamental Theorem of Natural Selection:  UnmeasuredGenotypes  11-29Some Implications of the Fundamental Equations of NaturalSelection 11-33The Course of Adaptation and Natural Selection 11-47Chapter 12.  Interactions of Natural Selection with Other Evolutionary Forcesand the Detection of Natural Selection      12-1The Interaction of Natural Selection with Mutation   12-3The Interaction of Natural Selection with Mutation and System ofMating   12-8The Interaction of Natural Selection with Gene Flow 12-12The Interaction of Natural Selection with Genetic Drift 12-21The Interactions of Natural Selection, Genetic Drift, andGene Flow 12-28The Interactions of Natural Selection, Genetic Drift, and Mutation 12-45The Interactions of Natural Selection, Genetic Drift, Mutation, andRecombination 12-65Candidate Loci 12-71Quantitative Genetic Approaches to Detecting Selection 12-75The Neutralist/Selectionist Debate 12-80Chapter 13.  Units and Targets of Selection   13-1The Unit of Selection   13-4Targets of Selection Below the Level of the Individual 13-18Targets of Selection Above the Level of the Individual 13-51Chapter 14.  Selection in Heterogeneous Environments   14-1Coarse-Grained Spatial Heterogeneity   14-4Coarse-Grained Temporal Heterogeneity 14-34Fine-Grained Heterogeneity 14-56Coevolution 14-74Chapter 15.  Selection in Age-Structured Populations   15-1Life History and Fitness   15-3The Evolution of Senescence  15-13Abnormal Abdomen:  An Example of Selection in anAge-Structured Population  15-24Overview  15-63AppendicesAppendix 1.  Genetic Survey Techniques   A1-1Appendix 2.  Probability and Statistics   A2-1References     R-1Index

Alan R. Templeton, PhD, is Charles Rebstock Professor Emeritus of Biology and Statistical Genomics at Washington University in St. Louis. His research focus is on the application of molecular genetic techniques and statistical population genetics to a variety of basic and applied evolutionary problems. He is on the editorial boards of Molecular Phylogenetics and Evolution and Evolutionary Bioinformatics Online.

Select Guide Rating

• Preface to the 2nd Edition    ixChapter 1.  The Scope and Basic Premises of Population Genetics  1-1Basic Premises of Population Genetics  1-1Population Genomics1-12Section 1:  Population Structure and HistoryChapter 2.  Modeling Evolution and the Hardy-Weinberg Law  2-1How to Model Microevolution  2-1The Hardy-Weinberg Model  2-4Hardy-Weinberg for Two Loci2-19Chapter 3.  Systems of Mating  3-1Inbreeding  3-1Assortative Mating3-25Disassortative Mating3-45Chapter 4.  Genetic Drift  4-1Basic Evolutionary Properties of Genetic Drift  4-2Founder and Bottleneck Effects  4-7Genetic Drift and Disequilibrium4-11Genetic Drfit, Disequilibrium, and System of Mating4-13Effective Population Size4-18Chapter 5.  Genetic Drift in Large Populations and Coalescence  5-1Newly Arisen Mutations  5-1Neutral Alleles  5-3The Coalescent5-22Chapter 6.  Gene Flow and Population Subdivision  6-1Gene Flow Between Two Local Populations  6-1The Balance of Gene Flow and Drift  6-6An Example of the Balance of Drift and Gene Flow6-27Factors Influencing The Amount and Patter of Gene Flow6-42Total Effective Population Size in Subdivided Populations6-62Multiple Modes of Inheritance and Population Structure6-71Admixture6-76Identifying Subpopulations and Population Structure6-81A Final Warning6-96Chapter 7.  Population History  7-1Inferring Historical Effective Population Sizes  7-6Inferring Historical Gene Flow Patterns and Admixture 7-11Using Haplotype Trees to Study Population History 7-19Model Based Approaches to Phylogeographic Analysis 7-56Direct Studies Over Space and Past Times 7-70Historical Population Genetics and Macroevolution 7-75Section 2:  Genotype and PhenotypeChapter 8.  Basic Quantitative Genetic Definitions and Theory  8-1“Simple” Mendelian Phenotypes  8-2Nature Versus Nurture?  8-7The Fisherian Model of Quantitative Genetics8-13Chapter 9.  Quantitative Genetics:  Unmeasured Genotypes  9-1Correlation Between Relatives  9-2The Distinction Between Heritability and Inheritance9-17Response to Selection9-19The Problem of Between-Population Differences in MeanPhenotype 9-21Controlled Crosses for the Analysis of Between PopulationDifferences 9-30The Balance Between Mutation, Drift, and Gene Flow UponPhenotypic Variance 9-36Chapter 10.  Quantitative Genetics:  Measured Genotypes  10-1Marker Association Studies  10-5Candidate Loci10-35Candidate Loci and Genetic Architecture10-51Section 3:  Natural Selection and AdaptationChapter 11.  Natural Selection  11-1The Fundamental Equation of Natural Selection:  MeasuredGenotypes  11-4Sickle-Cell Anemia as an Example of Natural Selection 11-10Adaptation as a Polygenic Process 11-24The Fundamental Theorem of Natural Selection:  UnmeasuredGenotypes  11-29Some Implications of the Fundamental Equations of NaturalSelection 11-33The Course of Adaptation and Natural Selection 11-47Chapter 12.  Interactions of Natural Selection with Other Evolutionary Forcesand the Detection of Natural Selection      12-1The Interaction of Natural Selection with Mutation   12-3The Interaction of Natural Selection with Mutation and System ofMating   12-8The Interaction of Natural Selection with Gene Flow 12-12The Interaction of Natural Selection with Genetic Drift 12-21The Interactions of Natural Selection, Genetic Drift, andGene Flow 12-28The Interactions of Natural Selection, Genetic Drift, and Mutation 12-45The Interactions of Natural Selection, Genetic Drift, Mutation, andRecombination 12-65Candidate Loci 12-71Quantitative Genetic Approaches to Detecting Selection 12-75The Neutralist/Selectionist Debate 12-80Chapter 13.  Units and Targets of Selection   13-1The Unit of Selection   13-4Targets of Selection Below the Level of the Individual 13-18Targets of Selection Above the Level of the Individual 13-51Chapter 14.  Selection in Heterogeneous Environments   14-1Coarse-Grained Spatial Heterogeneity   14-4Coarse-Grained Temporal Heterogeneity 14-34Fine-Grained Heterogeneity 14-56Coevolution 14-74Chapter 15.  Selection in Age-Structured Populations   15-1Life History and Fitness   15-3The Evolution of Senescence  15-13Abnormal Abdomen:  An Example of Selection in anAge-Structured Population  15-24Overview  15-63AppendicesAppendix 1.  Genetic Survey Techniques   A1-1Appendix 2.  Probability and Statistics   A2-1References     R-1Index