Roger A. Barker BA, MBBS, MRCP, PhD, FMedSci, John van Geest Centre for Brain Repair and Department of Neurology, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.Francesca Cicchetti PhD, Centre de Recherche du CHU de Québec (CHUQ), Université Laval, Québec, Canada.Emma S.J. Robinson PhD, FBPhS, School of Physiology, Pharmacology & Neuroscience, University of Bristol, Bristol, UK.

• Introduction ixAcknowledgements xList of abbreviations xiCompanion website xvPart 1 Anatomical and functional organization 11 Development of the nervous system 22 Organization of the nervous system 43 Autonomic nervous system 64 Enteric nervous system 85 Meninges and cerebrospinal fluid 106 Blood supply to the central nervous system 127 Cranial nerves 148 Anatomy of the brainstem 169 Organization of the spinal cord 1810 Organization of the cerebral cortex and thalamus 2011 Hypothalamus 22Part 2 Cells and neurophysiology 2512 Cells of the nervous system I: neurones 2613 Cells of the nervous system II: neuroglial cells 2814 Ion channels 3015 Resting membrane and action potential 3216 Neuromuscular junction and synapses 3417 Nerve conduction and synaptic integration 3618 Neurotransmitters, receptors and their pathways 3819 Main CNS neurotransmitters and their function 4020 Skeletal muscle structure 4221 Skeletal muscle contraction 44Part 3 Sensory systems 4722 Sensory systems: an overview 4823 Sensory transduction 5024 Visual system I: the eye and retina 5225 Visual system II: the visual pathways and subcortical visual areas 5426 Visual system III: visual cortical areas 5627 Auditory system I: the ear and cochlea 5828 Auditory system II: auditory pathways and language 6029 Vestibular system 6230 Olfaction and taste 6431 Somatosensory system 6632 Pain systems I: nociceptors and nociceptive pathways 6833 Pain systems II: pharmacology and management 7034 Association cortices: the posterior parietal and prefrontal cortex 72Part 4 Motor systems 7535 Organization of the motor system 7636 Muscle spindle and lower motor neurone 7837 Spinal cord motor organization and locomotion 8038 Cortical motor areas 8239 Primary motor cortex 8440 Basal ganglia: anatomy and physiology 8641 Basal ganglia: diseases and their treatments 8842 Cerebellum 91Part 5 Cognition and neural plasticity 9543 Reticular formation and sleep 9644 Limbic system and long-term potentiation 9845 Memory 10046 Emotion, motivation and drug addiction 10247 Neural plasticity and neurotrophic factors I: the peripheral nervous system 10448 Neural plasticity and neurotrophic factors II: the central nervous system 10649 Techniques for studying the nervous system 108Part 6 Applied neurobiology: the principles of neurology and psychiatry 11150 Approach to the patient with neurological problems 11251 Examination of the nervous system 11452 Investigation of the nervous system 11653 Imaging of the central nervous system 11854 Clinical disorders of the sensory systems 12055 Clinical disorders of the motor systems 12256 Eye movements 12457 Neurochemical disorders I: affective disorders 12658 Neurochemical disorders II: schizophrenia 12859 Neurochemical disorders III: anxiety 13060 Neurodegenerative disorders 13261 Neurophysiological disorders: epilepsy 13462 Neuroimmunological disorders 13663 Neurogenetic disorders 13864 Cerebrovascular disease 14065 Neuroradiological anatomy 142Part 7 History of neuroscientific discoveries 14566 Historical neuroscience discoveries 146Part 8 Self-assessment case studies 149Case studies and questions 150Answers 156Index 161

Roger A. Barker BA, MBBS, MRCP, PhD, FMedSci, John van Geest Centre for Brain Repair and Department of Neurology, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.Francesca Cicchetti PhD, Centre de Recherche du CHU de Québec (CHUQ), Université Laval, Québec, Canada.Emma S.J. Robinson PhD, FBPhS, School of Physiology, Pharmacology & Neuroscience, University of Bristol, Bristol, UK.

• Introduction ixAcknowledgements xList of abbreviations xiCompanion website xvPart 1 Anatomical and functional organization 11 Development of the nervous system 22 Organization of the nervous system 43 Autonomic nervous system 64 Enteric nervous system 85 Meninges and cerebrospinal fluid 106 Blood supply to the central nervous system 127 Cranial nerves 148 Anatomy of the brainstem 169 Organization of the spinal cord 1810 Organization of the cerebral cortex and thalamus 2011 Hypothalamus 22Part 2 Cells and neurophysiology 2512 Cells of the nervous system I: neurones 2613 Cells of the nervous system II: neuroglial cells 2814 Ion channels 3015 Resting membrane and action potential 3216 Neuromuscular junction and synapses 3417 Nerve conduction and synaptic integration 3618 Neurotransmitters, receptors and their pathways 3819 Main CNS neurotransmitters and their function 4020 Skeletal muscle structure 4221 Skeletal muscle contraction 44Part 3 Sensory systems 4722 Sensory systems: an overview 4823 Sensory transduction 5024 Visual system I: the eye and retina 5225 Visual system II: the visual pathways and subcortical visual areas 5426 Visual system III: visual cortical areas 5627 Auditory system I: the ear and cochlea 5828 Auditory system II: auditory pathways and language 6029 Vestibular system 6230 Olfaction and taste 6431 Somatosensory system 6632 Pain systems I: nociceptors and nociceptive pathways 6833 Pain systems II: pharmacology and management 7034 Association cortices: the posterior parietal and prefrontal cortex 72Part 4 Motor systems 7535 Organization of the motor system 7636 Muscle spindle and lower motor neurone 7837 Spinal cord motor organization and locomotion 8038 Cortical motor areas 8239 Primary motor cortex 8440 Basal ganglia: anatomy and physiology 8641 Basal ganglia: diseases and their treatments 8842 Cerebellum 91Part 5 Cognition and neural plasticity 9543 Reticular formation and sleep 9644 Limbic system and long-term potentiation 9845 Memory 10046 Emotion, motivation and drug addiction 10247 Neural plasticity and neurotrophic factors I: the peripheral nervous system 10448 Neural plasticity and neurotrophic factors II: the central nervous system 10649 Techniques for studying the nervous system 108Part 6 Applied neurobiology: the principles of neurology and psychiatry 11150 Approach to the patient with neurological problems 11251 Examination of the nervous system 11452 Investigation of the nervous system 11653 Imaging of the central nervous system 11854 Clinical disorders of the sensory systems 12055 Clinical disorders of the motor systems 12256 Eye movements 12457 Neurochemical disorders I: affective disorders 12658 Neurochemical disorders II: schizophrenia 12859 Neurochemical disorders III: anxiety 13060 Neurodegenerative disorders 13261 Neurophysiological disorders: epilepsy 13462 Neuroimmunological disorders 13663 Neurogenetic disorders 13864 Cerebrovascular disease 14065 Neuroradiological anatomy 142Part 7 History of neuroscientific discoveries 14566 Historical neuroscience discoveries 146Part 8 Self-assessment case studies 149Case studies and questions 150Answers 156Index 161