Roger A. Barker - Böcker

Huntington's disease (HD) is an inherited progressive neurodegenerative disorder. Although onset of Huntington's Disease usually occurs in adulthood, the age of onset of the condition is extremely variable with approximately 5-10% of cases having an onset of less than 20 years, or Juvenile Huntington's Disease (JHD). While JHD shares many of the clinical features of adult HD (e.g., chorea and personality disorders), patients with JHD often experience additional problems including seizures, dystonia and Parkinsonism. Diagnosis in patients with JHD is often delayed because of the failure of clinicians to recognise the characteristic features of the condition. While several textbooks have been published on HD, no books have been published to date focussing solely on the juvenile onset form of the disease. This book summarises, for the first time, the clinical and scientific knowledge available on JHD. It also collects together accounts from families affected by the condition, putting the clinical and scientific chapters into context.Edited by members of the working group on Juvenile Huntington's Disease within the European Huntington Disease Network (EHDN), this book forms the first comprehensive text on JHD and is of interest to neurologists, geneticists, academic/research scientists and other healthcare professionals.

Originally published in 1999, this book begins with a synopsis of experimental work underlying degeneration and recovery in the nervous system, which is then discussed in the context of strategies to repair the central nervous system (CNS) and peripheral nervous system (PNS). The major part of the book is given over to the approach involving the use of transplanted tissues to replace and restore disrupted neural networks. This experimental work has formed the basis for the emerging clinical trials employing neural grafts for diseases such as Parkinson's and Huntington's, which are discussed in detail. The book then goes on to discuss newer cellular strategies involving the manipulation of neural cells both in culture and genetically, an approach that may ultimately be employed in the clinical situation.Neural Repair, Transplantation and Rehabilitation is unique in bridging the gap from experimental studies to clinical trials, whilst also providing the non-specialist with a background in rehabilitation strategies as well as basic neuroscience. It is recommended for all those involved in the management of patients with degenerative and traumatic injuries to the nervous system. Today it can be read in its historical context.

British Medical Association Book Award Winner - Student Textbook of the Year 2018Everything you need to know about Neuroanatomy and Neuroscience … at a Glance!Neuroanatomy and Neuroscience at a Glance is a highly illustrated, quick reference guide to the anatomy, biochemistry, physiology and pharmacology of the human nervous system. Each chapter features a summary of the anatomical structure and function of a specific component of the central nervous system, a section on applied neurobiology outlining how to approach a patient with neurological or psychiatric problems aligned to the chapter topic, standard diagnostic procedures for most common scenarios, as well as an overview of treatment and management options.This fully updated and expanded new edition includes:  Dozens of full-page, colour illustrations and neurological scansExpanded coverage of techniques to study the nervous systemMore practical information on the neurological examNew content on neuropharmacology and drug therapiesBullet points and bold terms throughout assist with revision and review of the topicNeuroanatomy and Neuroscience at a Glance is the ideal companion for students embarking on a neuroanatomy or neuroscience course, and is an excellent reference tool for those in clinical training.An updated companion website with new clinical cases, multiple choice self-assessment questions, revision slides, and downloadable illustrations and flashcards is available at www.ataglanceseries.com/neuroscience