Metals in Medicine

James C. DabrowiakDepartment of Chemistry, Syracuse University, USA

• Feature Boxes xvPreface to the Second Edition xviiPreface to the First Edition xixAcknowledgments xxiAbout the Companion Website xxiii1 Inorganic Chemistry Basics 11.1 Introduction 11.2 Crystal Field Theory 11.3 Molecular Orbital Theory 121.4 Absorption Spectra of Metal Complexes 221.5 Magnetic Properties of Metal Complexes 331.6 Structure and Reactivity of Metal Complexes 352 Metallo-Drugs and Their Action 592.1 Introduction 592.2 Proteins asTargets forMetallo-Drugs 592.3 DNAas aTarget forMetallo-Drugs 712.4 Reaction of Metal Complexes in the Biological Milieu 762.5 Evaluating the Pharmacological Effects of Agents 792.6 FromDiscoverytotheClinic 823 Platinum Drugs for Treating Cancer 913.1 Introduction 913.2 Cisplatin 913.3 Carboplatin 1153.4 Oxaliplatin 1263.5 RegionallyUsedPlatinumDrugs 1333.6 Platinum Agents in Preclinical Development 1354 Anticancer Agents Beyond Cisplatin 1574.1 Introduction 1574.2 Ruthenium Anticancer Agents 1574.3 Gold Anticancer Agents 1734.4 Titanium Compounds for Treating Cancer 1814.5 Gallium for Treating Cancer 1874.6 Other Anticancer Active Metal Complexes 1945 Responsive Metal Complexes 2175.1 Introduction 2175.2 Prodrug Activation by Redox 2175.3 ProdrugActivationbypH 2255.4 Prodrug Activation by Enzymes 2275.5 ProdrugActivationbyLight 2295.6 Photodynamic Therapy 2336 Metal Complexes for Treating Arthritis and Diabetes 2456.1 Introduction 2456.2 ChemistryofGoldinBiologicalMedia 2456.3 Gold Compounds for Treating Arthritis 2476.4 Vanadium Compounds for Treating Diabetes 2637 Metal Complexes for Killing Parasites, Bacteria and Viruses 2857.1 Introduction 2857.2 Malaria 2857.3 Leishmaniasis 2937.4 American Trypanosomiasis (Chagas Disease) 2987.5 Human African Trypanosomiasis 3017.6 Tuberculosis 3017.7 PepticUlcerDisease 3067.8 Syphilis 3117.9 Bacterial Infections 3127.10 Acquired Immunodeficiency Syndrome (AIDS) 3148 Metal Ion Imbalance in the Body 3298.1 Introduction 3298.2 Alzheimer’s Disease 3298.3 LithiumandtheBrain 3378.4 Wilson’s Disease: Copper Overload 3388.5 Menkes Disease: Copper Deficiency 3408.6 Beta-Thalassemia: IronOverload 3428.7 Iron-Deficiency Anemia 3448.8 Calcium Imbalance 3448.9 ChelationTherapy 3469 Metal Complexes for Detecting Disease 3579.1 Introduction 3579.2 Technetium in Diagnostic Nuclear Medicine 3589.3 Metal Compounds as Contrast Agents for MRI 3719.4 Radiotherapy 38210 Nanomedicine 39510.1 Introduction 39510.2 Circulation, Uptake, and Elimination of Nanoparticles 39610.3 Nanoscience for Treating Cancer 40710.4 Nanoparticles for Detecting Disease 41910.5 Theranostic Nanoparticles 42610.6 Cytotoxicity of Nanoparticles 428Index 441