ROSA ARBORETTI is Associate Professor of Statistics at the Department of Civil, Environmental and Architectural Engineering at the University of Padova, Italy. MATTIA DE DOMINICIS is a former R&D Vice-President in Household and Personal Care at Reckitt Benckiser in Venice, Italy. CHRIS JONES is Vice President of R&D in Hygiene Home at Reckitt Benckiser in Montvale, USA. LUIGI SALMASO is Full Professor of Statistics and Deputy Chair of the Department of Management and Engineering at the University of Padova, Italy.

• Biographies viiPreface ixAbout the Companion Website xi1 Basic Statistical Background 11.1 Introduction 12 The Screening Phase 232.1 Introduction 232.2 Case Study: Air Freshener Project 242.2.1 Plan of the Screening Experiment 242.2.2 Plan of the Statistical Analyses 373 Product Development and Optimization 573.1 Introduction 573.2 Case Study for Single Sample Experiments: Throat Care Project 593.2.1 Comparing the Mean to a Specified Value 603.2.2 Comparing a Proportion to a Specified Value 673.3 Case Study for Two‐Sample Experiments: Condom Project 733.3.1 Comparing Variability Between Two Groups 743.3.2 Comparing Means Between Two Groups 813.3.3 Comparing Two Proportions 853.4 Case Study for Paired Data: Fragrance Project 933.5 Case Study: Stain Removal Project 1043.5.1 Plan of the General Factorial Experiment 1043.5.2 Plan of the Statistical Analyses 1104 Other Topics in Product Development and Optimization: Response Surface and Mixture Designs 1374.1 Introduction 1374.2 Case Study for Response Surface Designs: Polymer Project 1384.2.1 Plan of the Experimental Design 1394.2.2 Plan of the Statistical Analyses 1504.3 Case Study for Mixture Designs: Mix‐Up Project 1664.3.1 Plan of the Experimental Design 1674.3.2 Plan of the Statistical Analyses 1995 Product Validation 2135.1 Introduction 2135.2 Case Study: GERD Project 2155.2.1 Evaluation of the Relationship among Quantitative Variables 2155.3 Case Study: Shelf Life Project (Fixed Batch Factor) 2435.4 Case Study: Shelf Life Project (Random Batch Factor) 2506 Consumer Voice 2576.1 Introduction 2576.2 Case Study: “Top‐Two Box” Project 2596.3 Case Study: DOE – Top Score Project 2846.3.1 Plan of the Factorial Design 2846.3.2 Plan of the Statistical Analyses 2856.4 Final Remarks 291References 293Index 295

ROSA ARBORETTI is Associate Professor of Statistics at the Department of Civil, Environmental and Architectural Engineering at the University of Padova, Italy. MATTIA DE DOMINICIS is a former R&D Vice-President in Household and Personal Care at Reckitt Benckiser in Venice, Italy. CHRIS JONES is Vice President of R&D in Hygiene Home at Reckitt Benckiser in Montvale, USA. LUIGI SALMASO is Full Professor of Statistics and Deputy Chair of the Department of Management and Engineering at the University of Padova, Italy.

• Biographies viiPreface ixAbout the Companion Website xi1 Basic Statistical Background 11.1 Introduction 12 The Screening Phase 232.1 Introduction 232.2 Case Study: Air Freshener Project 242.2.1 Plan of the Screening Experiment 242.2.2 Plan of the Statistical Analyses 373 Product Development and Optimization 573.1 Introduction 573.2 Case Study for Single Sample Experiments: Throat Care Project 593.2.1 Comparing the Mean to a Specified Value 603.2.2 Comparing a Proportion to a Specified Value 673.3 Case Study for Two‐Sample Experiments: Condom Project 733.3.1 Comparing Variability Between Two Groups 743.3.2 Comparing Means Between Two Groups 813.3.3 Comparing Two Proportions 853.4 Case Study for Paired Data: Fragrance Project 933.5 Case Study: Stain Removal Project 1043.5.1 Plan of the General Factorial Experiment 1043.5.2 Plan of the Statistical Analyses 1104 Other Topics in Product Development and Optimization: Response Surface and Mixture Designs 1374.1 Introduction 1374.2 Case Study for Response Surface Designs: Polymer Project 1384.2.1 Plan of the Experimental Design 1394.2.2 Plan of the Statistical Analyses 1504.3 Case Study for Mixture Designs: Mix‐Up Project 1664.3.1 Plan of the Experimental Design 1674.3.2 Plan of the Statistical Analyses 1995 Product Validation 2135.1 Introduction 2135.2 Case Study: GERD Project 2155.2.1 Evaluation of the Relationship among Quantitative Variables 2155.3 Case Study: Shelf Life Project (Fixed Batch Factor) 2435.4 Case Study: Shelf Life Project (Random Batch Factor) 2506 Consumer Voice 2576.1 Introduction 2576.2 Case Study: “Top‐Two Box” Project 2596.3 Case Study: DOE – Top Score Project 2846.3.1 Plan of the Factorial Design 2846.3.2 Plan of the Statistical Analyses 2856.4 Final Remarks 291References 293Index 295

ROSA ARBORETTI is Associate Professor of Statistics at the Department of Civil, Environmental and Architectural Engineering at the University of Padova, Italy. MATTIA DE DOMINICIS is a former R&D Vice-President in Household and Personal Care at Reckitt Benckiser in Venice, Italy. CHRIS JONES is Vice President of R&D in Hygiene Home at Reckitt Benckiser in Montvale, USA. LUIGI SALMASO is Full Professor of Statistics and Deputy Chair of the Department of Management and Engineering at the University of Padova, Italy.

• Biographies viiPreface ixAbout the Companion Website xi1 Basic Statistical Background 11.1 Introduction 12 The Screening Phase 232.1 Introduction 232.2 Case Study: Air Freshener Project 242.2.1 Plan of the Screening Experiment 242.2.2 Plan of the Statistical Analyses 373 Product Development and Optimization 573.1 Introduction 573.2 Case Study for Single Sample Experiments: Throat Care Project 593.2.1 Comparing the Mean to a Specified Value 603.2.2 Comparing a Proportion to a Specified Value 673.3 Case Study for Two‐Sample Experiments: Condom Project 733.3.1 Comparing Variability Between Two Groups 743.3.2 Comparing Means Between Two Groups 813.3.3 Comparing Two Proportions 853.4 Case Study for Paired Data: Fragrance Project 933.5 Case Study: Stain Removal Project 1043.5.1 Plan of the General Factorial Experiment 1043.5.2 Plan of the Statistical Analyses 1104 Other Topics in Product Development and Optimization: Response Surface and Mixture Designs 1374.1 Introduction 1374.2 Case Study for Response Surface Designs: Polymer Project 1384.2.1 Plan of the Experimental Design 1394.2.2 Plan of the Statistical Analyses 1504.3 Case Study for Mixture Designs: Mix‐Up Project 1664.3.1 Plan of the Experimental Design 1674.3.2 Plan of the Statistical Analyses 1995 Product Validation 2135.1 Introduction 2135.2 Case Study: GERD Project 2155.2.1 Evaluation of the Relationship among Quantitative Variables 2155.3 Case Study: Shelf Life Project (Fixed Batch Factor) 2435.4 Case Study: Shelf Life Project (Random Batch Factor) 2506 Consumer Voice 2576.1 Introduction 2576.2 Case Study: “Top‐Two Box” Project 2596.3 Case Study: DOE – Top Score Project 2846.3.1 Plan of the Factorial Design 2846.3.2 Plan of the Statistical Analyses 2856.4 Final Remarks 291References 293Index 295