Drug Transporters

Molecular Characterization and Role in Drug Disposition

AvGuofeng You,Marilyn E. Morris

Inbunden, Engelska, 2022

Del i serien Wiley Series in Drug Discovery and Development

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Beskrivning

DRUG TRANSPORTERS Drug transporter fundamentals and relevant principles and techniques, featuring new and expanded chapters Drug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques. The updated and expanded third edition includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modeling, and the use of transporters as therapeutic targets for diseases. Reflects the current state of the field and offers perspectives on future directionsCovers basic knowledge, clinical outcomes, and emerging discoveries in transporter scienceProvides up-to-date information on drug transporter families, mechanisms, and clinical implicationsIncludes extensive references and numerous figures and tables throughoutUnderstandable for novices while offering sufficient depth for more experienced researchers, Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition is an excellent textbook for pharmacological or physiological science courses in drug/membrane transport, and an invaluable reference for academic or industrial scientists working in the transporter field and related areas of drug metabolism, pharmacokinetics, and pharmacodynamics.

Produktinformation

Utgivningsdatum:2022-04-22
Mått:10 x 10 x 10 mm
Vikt:454 g
Format:Inbunden
Språk:Engelska
Serie:Wiley Series in Drug Discovery and Development
Antal sidor:576
Upplaga:3
Förlag:John Wiley & Sons Inc
ISBN:9781119737551

Utforska kategorier

Kemi inom Naturvetenskap och teknik
Biologi inom Naturvetenskap och teknik

Mer om författaren

Guofeng You, PhD, Distinguished Professor of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, New Jersey, USA.Marilyn E. Morris, PhD, SUNY Distinguished Professor and Chair, Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, USA.

Innehållsförteckning

List of ContributorsPrefaceCHAPTER 1. Overview of Drug Transporter FamiliesGuofeng You and Marilyn E. MorrisCHAPTER 2. Organic Cation and Zwitterion TransportersMegan L. Koleske, Xiaomin Liang, Osatohanmwen Jessica Enogieru, Dina Buitrago, and KathleenM. GiacominiCHAPTER 3. Multidrug and Toxin Extrusion ProteinsLauren M. Aleksunes, Victoria Woo, and Melanie S. JoyCHAPTER 4. Organic Anion Transporters (OATs)Jeffry C. Granados, Jingui Zhang, Guofeng You, Sanjay K. NigamCHAPTER 5. Organic Anion Transporting Polypeptides OATPRommel G. Tirona and Richard B. KimCHAPTER 6. Mammalian Oligopeptide TransportersStephen M. Carl, Dea Herrera-Ruiz, Rajinder K. Bhardwaj, Olafur Gudmundsson, Stephanie Mowery, and Gregory T. Knipp.CHAPTER 7. Monocarboxylic Acid TransportersMarilyn E. Morris and Nisha V. KwatraCHAPTER 8. The Nucleoside Transporters CNTs and ENTsRaj Govindarajan, Antonio López Quiñones, and Joanne WangCHAPTER 9. Bile Acid TransportersEbehiremen N. Ayewoh and Peter W. SwaanCHAPTER 10. The P-glycoprotein Multidrug TransporterAndaleeb Sajid, Sabrina Lusvarghi and Suresh V. AmbudkarCHAPTER 11. Multidrug Resistance Proteins of the ABCC SubfamilyAnne T. Nies and Franziska KleinCHAPTER 12. ABCG2, the Breast Cancer Resistance Protein (BCRP)Robert W. Robey, Sabrina Lusvarghi, Cindy H. Chau, Agnes Basseville, William D. Figg, Suresh V. Ambudkar, and Susan E. BatesCHAPTER 13. Drug Transport in the LiverNoora Sjöstedt, Jeffry Adiwidjaja, William A. Murphy, and Kim L.R. BrouwerCHAPTER 14. Drug Transport in the BrainVishal Sangha, Erica I. Williams, Patrick T. Ronaldson, and Reina BendayanCHAPTER 15. Drug Transport in the KidneyDouglas H. SweetCHAPTER 16. Drug transporters in the human intestineStefan OswaldCHAPTER 17. Drug Transport in the PlacentaQingcheng Mao, Vadivel Ganapathy, and Jashvant D. UnadkatCHAPTER 18. Polymorphisms of drug transporters and clinical relevanceTore B. Stage and Deanna L. KroetzCHAPTER 19. Ontogeny of Drug TransportersMelanie A. Felmlee and Qing ZhangCHAPTER 20. Experimental Approaches for Studying Drug TransportersYusuke Masuo, Azusa Futatsugi, and Yukio KatoCHAPTER 21. Transporters mediated drug disposition – Physiochemistry and in silico approachesManthena V. S. Varma, Ayman El-Kattan, and Yurong LaiCHAPTER 22. In vitro-in vivo scale-up of drug transport activitiesKazuya Maeda and Yuichi SugiyamaCHAPTER 23. Application of Physiologically Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Modeling Comprising Transporters: Delineating the Role of Various Factors in Drug Disposition and ToxicityMatthew D. Harwood, Amin Rostami-Hodjegan, and Sibylle NeuhoffCHAPTER 24. Transporters as therapeutic targets in human diseasesRobert S. Jones and Eugene C. ChenCHAPTER 25. Diet/Nutrient Interactions with Drug TransportersMarilyn E. Morris and Tianjing RenIndex