Wiley Series in Drug Discovery and Development – serie
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27 produkter
Evaluation of Drug Candidates for Preclinical Development
Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology
Inbunden, 2010
1600 kr
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Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluationIt is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug …
Dopamine Transporters
Chemistry, Biology, and Pharmacology
Av Editor:Mark L. Trudell, Editor:Sari Izenwasser m. fl.
Inbunden, 2008
1934 kr
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Understanding the dopamine transporter can lead to new therapies for neurological disorders This book consolidates current information on the dopamine transporter (DAT) in relationto medicinal chemistry and synthesis, biology and pathology, and pharmacology. Because of DAT's role in diseases such …
HIV-1 Integrase
Mechanism and Inhibitor Design
Inbunden, 2011
2136 kr
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This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with …
Carbohydrate-Based Vaccines and Immunotherapies
Av Zhongwu Guo, Zhongwu Guo m. fl.
Inbunden, 2009
2070 kr
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The fundamental science and the latest developments in carbohydrate-based vaccinesThe relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines …
ABC Transporters and Multidrug Resistance
Av Ahcène Boumendjel, Jean Boutonnat m. fl.
Inbunden, 2009
2062 kr
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A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as …
Oral Bioavailability
Basic Principles, Advanced Concepts, and Applications
Av Xiaoling Li, Ming Hu
Inbunden, 2011
2507 kr
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Understand and assess the design, delivery, and efficacy of orally administered drugsA practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help …
Drug Design of Zinc-Enzyme Inhibitors
Functional, Structural, and Disease Applications
Av Claudiu T. Supuran, Jean-Yves Winum
Inbunden, 2009
3120 kr
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Brings together functional and structural information relevant to the design of drugs targeting zinc enzymesThe second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug …
Kinase Inhibitor Drugs
Av Rongshi Li, Jeffrey A. Stafford m. fl.
Inbunden, 2009
1992 kr
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A comprehensive resource on case studies of marketed kinase drugs and promising drug trialsSince the discovery of protein kinase activity in 1954, the field of protein kinase drug discovery has advanced dramatically. With the ongoing clinical success of the Bcr-Abl kinase inhibitor Gleevec in the …
Dendrimer-Based Drug Delivery Systems
From Theory to Practice
Inbunden, 2012
2481 kr
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The opportunities and challenges of using dendrimers to improve drug deliveryAmong pharmaceutical and biomedical researchers, the use of dendrimers in drug delivery systems has attracted increasing interest. In particular, researchers have noted that the volume of a dendrimer increases when it has …
Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System
From Biology to Drug Discovery
Av Nicholas J. Brandon, Anthony R. West
Inbunden, 2014
1600 kr
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This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed …
Plant Bioactives and Drug Discovery
Principles, Practice, and Perspectives
Inbunden, 2012
2481 kr
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An in-depth exploration of the applications of plant bioactive metabolites in drug research and developmentHighlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives …
Chemosensors
Principles, Strategies, and Applications
Av Binghe Wang, Eric V. Anslyn
Inbunden, 2011
2131 kr
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A thorough, accessible, and general overview of chemosensorsProviding a comprehensive overview of chemosensorsorganic molecules designed to bind and sense small molecules or metal ionsand their applications, Chemosensors: Principles, Strategies, and Applications is an accessible one-stop resource …
Carbohydrate Recognition
Biological Problems, Methods, and Applications
Av Binghe Wang, Binghe Wang m. fl.
Inbunden, 2011
1997 kr
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This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural …
Medicinal Chemistry of Nucleic Acids
Av Li-He Zhang, Lihe Zhang m. fl.
Inbunden, 2011
2136 kr
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Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biologyAssembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough …
Computer Applications in Pharmaceutical Research and Development
Av Sean Ekins
Inbunden, 2006
2547 kr
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A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of …
Aminoglycoside Antibiotics
From Chemical Biology to Drug Discovery
Av Dev P. Arya
Inbunden, 2007
2305 kr
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Advances that open new avenues in developing aminoglycoside antibiotics During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new …
Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors
Drug Discovery and Development
Av Ana Martinez, Ana Castro m. fl.
Inbunden, 2006
2173 kr
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Many researchers believe that GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, depression and bipolar disorder, and some forms of cancer. This book provides a thorough introduction to GSK-3, presents up-to-date information, and mentions …
Drug-Drug Interactions in Pharmaceutical Development
Inbunden, 2007
1441 kr
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Drug-Drug Interactions in Pharmaceutical Development comprehensively reviews the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. It focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a …
Drug Delivery
Principles and Applications
Av Binghe Wang, Longqin Hu m. fl.
Inbunden, 2016
1886 kr
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Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and …
Oral Bioavailability and Drug Delivery
From Basics to Advanced Concepts and Applications
Av Ming Hu, Xiaoling Li
Inbunden, 2024
3310 kr
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ORAL BIOAVAILABILITY AND DRUG DELIVERY Improve the performance and viability of newly-developed and approved drugs with this crucial guide Bioavailability is the parameter which measures the rate and extent to which a drug reaches a user’s circulatory system depending on the method of …
Nucleic Acids in Medicinal Chemistry and Chemical Biology
Drug Development and Clinical Applications
Av Lihe Zhang, Xinjing Tang m. fl.
Inbunden, 2023
2694 kr
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Nucleic Acids in Medicinal Chemistry and Chemical Biology An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished …
Drug Transporters
Molecular Characterization and Role in Drug Disposition
Av Guofeng You, Marilyn E. Morris
Inbunden, 2022
2986 kr
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DRUG TRANSPORTERS Drug transporter fundamentals and relevant principles and techniques, featuring new and expanded chapters Drug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug …
Carbon Monoxide in Drug Discovery
Basics, Pharmacology, and Therapeutic Potential
Av Binghe Wang, Binghe Wang m. fl.
Inbunden, 2022
2710 kr
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CARBON MONOXIDE IN DRUG DISCOVERY An insightful reference for the latest physiological and therapeutic studies of carbon monoxide In Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential, a team of distinguished authors delivers foundational knowledge, the latest …
Hydrogen Sulfide
Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies
Av Michael D Pluth, Michael D. Pluth
Inbunden, 2022
2694 kr
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HYDROGEN SULFIDE Covers H2S interactions, methods of detection and delivery in biological environments, and a wide range of applications Research on hydrogen sulfide (H2S) spans diverse disciplines including chemistry, biology, and physiology. In recent years, new materials and approaches have been …
Drug Delivery, 3 Volume Set
Principles and Applications
Av Binghe Wang, Longqin Hu m. fl.
Inbunden, 2027
3398 kr
Kommande
Drug Transporters
Molecular Characterization and Role in Drug Disposition
Av G You, Guofeng You m. fl.
E-bok, 2014
1807 kr
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This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, featuring new chapters on multidrug and toxin extrusion proteins, placental transport, in silico approaches in drug discovery, and regulatory guidance for drug transport studies in …
Nucleic Acids in Medicinal Chemistry and Chemical Biology
Drug Development and Clinical Applications
Av Lihe Zhang, Xinjing Tang m. fl.
2022
3176 kr
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