Lihe Zhang – författare

Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acid chemistry and biology Essential information on the use of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.

Nucleic Acids in Medicinal Chemistry and Chemical Biology An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field. Readers will also find: A thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistryComprehensive explorations of the methods used to determine the development of nucleic acid drugsPractical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical librariesIn-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistryPerfect for medicinal and nucleic acid chemists, Nucleic Acids in Medicinal Chemistry and Chemical Biology will also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.

This book constitutes the proceedings of the 7th International Conference on Intelligence Science and Big Data Engineering, IScIDE 2017, held in Dalian, China, in September 2017.The 48 full papers and 14 short papers presented in this volume were carefully reviewed and selected from 121 submissions. biomedical signal processing;

In diesem Buch wird ein umfangreiches Forschungsprogramm zur Erforschung von Signaltransduktionsprozessen mithilfe von Sonden mit kleinen Molekülen vorgestellt. Das Programm wurde von der National Natural Science Foundation of China während des 11. Fünfjahresplans ins Leben gerufen, der im Oktober 2008 begann und Ende 2016 abgeschlossen wurde. Der Bericht fasst zunächst die allgemeinen wissenschaftlichen Ziele und den aktuellen Stand der Signaltransduktionsforschung in China und an der internationalen Grenze zusammen. Basierend auf den neuen Methoden und Technologien, die im Bereich der niedermolekularen Sonden erreicht wurden, veranschaulicht dieses Buch die molekularen Schlüsselereignisse bei Signaltransduktionsprozessen in lebenden Systemen und zeigt die Regulation der Signaltransduktion auf. Dies trägt dazu bei, neue Ideen und Strategien für die Diagnose und Vorbeugung von schweren Krankheiten zu erforschen. Darüber hinaus werden in diesem Buch durch die interdisziplinäre Zusammenarbeit von Biologie und Chemie einige wichtige wissenschaftliche Probleme in der Biologie gelöst und neue Entwicklungen auf diesen Gebieten gefördert. Zu diesen Bereichen gehören die Herstellung von Sonden aus kleinen Molekülen zur Untersuchung der Signaltransduktion und die Entwicklung von Nachweismethoden zur Erfassung von Informationen über die Aktivitäten von Biomakromolekülen.Aufgrund seines Umfangs ist das Buch für Forscher interessant, die in den Bereichen organische Chemie, Naturstoffchemie, medizinische Chemie, analytische Chemie und physikalische Chemie arbeiten. Es fördert auch die multidisziplinäre Zusammenarbeit zwischen Chemie, Medizin, Materialwissenschaft und Biologie.

This book presents a major research program investigating signal transduction processes utilizing small molecule compound probes. The program was launched by the National Natural Science Foundation of China during the 11th Five-Year Plan period, which was started in October 2008 and concluded at the end of 2016. It first summarizes the overall scientific objectives and the current situation of signal transduction research in China and the international frontier. Based on the new method and technologies achieved in small molecule compound probes, this book illustrates key molecular events in signal transduction processes in living systems and reveals the regulation of signal transduction. This helps to explore new ideas and strategies for the diagnosis and prevention of serious diseases. In addition, via interdisciplinary cooperation of biology and chemistry, this book solves some key scientific problems in biology and promotes recent developments in these fields. These areas include the generation of small molecule compound probes for studying signal transduction and development of detecting methods for gathering information of biomacromolecule activities. Given its scope, the book is of interest to researchers who work in organic chemistry, natural product chemistry, medicinal chemistry, analytical chemistry and physical chemistry. It also promotes the multidisciplinary collaboration among chemistry, medicine, materials science and biology