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    1. Naturvetenskap och teknik
    2. Matematik och naturvetenskap
    3. Biologi
    4. Biokemi

    Medicinal Chemistry of Nucleic Acids

    AvLi-He Zhang,Lihe Zhang

    Inbunden, Engelska, 2011

    Del 16 i serien Wiley Series in Drug Discovery and Development

    2 067 kr

    Beställningsvara. Skickas inom 5-8 vardagar. Fri frakt över 249 kr.

    Beskrivning

    Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biologyAssembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistryA close look at a large range of current topics on nucleic acid chemistry and biologyEssential information on the use of nucleic acid drugs to treat diseases like cancerA thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research areaThorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.

    Produktinformation

    • Utgivningsdatum:2011-09-30
    • Mått:163 x 243 x 27 mm
    • Vikt:776 g
    • Format:Inbunden
    • Språk:Engelska
    • Serie:Wiley Series in Drug Discovery and Development
    • Antal sidor:464
    • Förlag:John Wiley & Sons Inc
    • Medarbetare:SidneyM. Hecht
    • ISBN:9780470596685

    Utforska kategorier

    • Biokemi inom Naturvetenskap och teknik
    • Farmakologi inom Medicin
    • Behandling och behandlingsmetoder inom Medicin

    Mer om författaren

    LI-HE ZHANG is President of the academic committee of State Key Laboratory of Natural and Biomimetic Drugs, as well as Professor of Medicinal Chemistry at Peking University. He is also a member of the Chinese Academy of Sciences, Fellow of the Royal Society of Chemistry, former vice president of the Chinese Pharmaceutical Association, and past president of the Asian Federation of Medicinal Chemistry. ZHEN XI, PhD, is Deputy Director of the State Key Laboratory of Elemento-organic Chemistry, as well as Professor of Pesticide Science and Chemical Biology, and Vice Dean of the College of Chemistry at Nankai University. He holds seven patents and has written a number of reviews and book chapters and sixty-four original research articles.JYOTI CHATTOPADHYAYA, PhD, DSc, is the University Chair of Bioorganic Chemistry and the chair of the Chemical Biology Program at Uppsala University. He is a guest professor of chemistry at both Jilin University and Nankai University. He has written over 410 peer-reviewed original research articles and is also on the editorial boards of several international journals.

    Recensioner i media

    "The book gives a good overview on some aspects of current research in the field. ... For those in the field seeking inspiration, it is a good book." (ChemMedChem, 2012)

    Innehållsförteckning

    • FOREWORD vii CONTRIBUTORS xiINTRODUCTION xv1 RECENT ADVANCES IN CARBOCYCLIC NUCLEOSIDES: SYNTHESIS AND BIOLOGICAL ACTIVITY 1Jianing Wang, Ravindra K. Rawal, and Chung K. Chu2 STRUCTURES AND FUNCTIONS OF NUCLEIC ACIDS MODIFIED WITH S, Se, AND Te AND COMPLEXED WITH SMALL MOLECULES 101Wen Zhang, Jia Sheng, and Zhen Huang3 UNRAVELING OF THE NAD CYCLIZING AND CALCIUM SIGNALING FUNCTIONS OF HUMAN CD38 142Hon Cheung Lee4 DNA AND RNA BINDING SMALL MOLECULES 164Shibo Li and Zhen Xi5 G-QUADRUPLEX DNA AND ITS LIGANDS IN ANTICANCER THERAPY 206Zhi-Shu Huang, Jia-Heng Tan, Tian-Miao Ou, Ding Li, and Lian-Quan Gu6 MOLECULAR MODELING IN NUCLEIC ACID-TARGETED DRUG DESIGN 258Lidan Sun, Hongwei Jin, Liangren Zhang, and Lihe Zhang7 STRUCTURE OF 10–23 DNAzyme IN COMPLEX WITH THE TARGET RNA IN SILICO—A PROGRESS REPORT ON THE MECHANISM OF RNA CLEAVAGE BY DNA ENZYME 272Oleksandr Plashkevych and Jyoti Chattopadhyaya8 LABELING OLIGONUCLEOTIDES TOWARD THE BIOMEDICAL PROBE 292Il Joon Lee and Byeang Hyean Kim9 LOCKED NUCLEIC ACID OLIGONUCLEOTIDES TOWARD CLINICAL APPLICATIONS 335Rakesh N. Veedu and Jesper Wengel10 THE PHARMACOKINETICS RESEARCH OF NUCLEIC ACID DRUGS 349Shengqi Wang, Dandan Lu, Qingqing Wang, Haifeng Song, Chan Gao, Caihong Liu, and Ying Wang11 INDUCIBLE RNAi AND DRUG TARGET VALIDATION 390Wei Xiong, Jing Zhao, Yufan Zhang, Jinxi Wang, Yong-Xiang Zheng, Qiu-Chen He, Li-He Zhang, and De-Min Zhou12 siRNA: THE SPECIFICITY AND OFF-TARGET EFFECTS 405Quan Du, Huang Huang, and Zicai LiangINDEX 423