Xiaoling Li – författare

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Design of Controlled Release Drug Delivery Systems

AvXiaoling Li

Inbunden, Engelska, 2005

1 766 kr

Skickas inom 3-6 vardagar

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.

A RIGOROUS EXPLORATION OF THE STATE OF THE ART IN CONTROLLED RELEASE DRUG DELIVERY

Written by an International team of experts, this comprehensive text offers pharmaceutical scientists and engineers working in the field, state-of-the-art design principles for the development and bioengineering of drug delivery systems/technology. Readers will find drug delivery systems presented with a particular emphasis on the design principles and their physiological/pathological basis. For each specific design principle, the contributors briefly introduce the relevant pharmacokinetics (where necessary) and include the challenges of different biological barriers that need to be overcome.

This in-depth text features detailed coverage of:

Physiological and biochemical barriers to drug deliveryPharmacokinetics and pharmacodynamics of drug deliveryDiffusion and dissolution strategiesProdrugsBioadhesive and gastric retentive systemsPhysiological and biochemical barriers to drug deliveryTargeted drug deliveryDevice controlled and programmable drug deliveryAnd more

A COMPREHENSIVE REFERENCE ON THE BIOCHEMICAL, PHYSICAL, AND TECHNICAL ASPECTS OF DRUG DELIVERY SYSTEMS* Pharmacokinetics and Pharmacodynamics: Applications in the Design of Controlled Release Drug Delivery Systems * Barriers to Drug Delivery: Physiological and Biochemical Aspects * Prodrugs as Delivery Systems * Diffusion Controlled Systems * Dissolution Controlled Systems * Osmotic Controlled Systems * Biodegradable Polymeric Delivery Systems * Gastric Retention Retentive Dosage Forms * Device Controlled Delivery of Powders * Physical Targeting of Approaches for Drug Delivery * Ligand Based Drug Targeting Approaches for Drug Delivery * Programmable Drug Delivery Systems * Carrier and Vector Mediated Delivery Systems for Biological Macromolecules

Del 16 - Wiley Series in Drug Discovery and Development

Oral Bioavailability

Basic Principles, Advanced Concepts, and Applications

AvXiaoling Li,Ming Hu

Inbunden, Engelska, 2011

2 337 kr

Skickas inom 3-6 vardagar

Understand and assess the design, delivery, and efficacy of orally administered drugsA practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability.The difference in rate and extent between a drug taken orally and the actual amount of a drug reaching the circulatory system, oral bioavailability is an essential parameter for determining the efficacy and adverse effects of new and developing medications, as well as finding an optimal dosing regimen.This book provides a much-needed one-stop resource to help readers better understand and appreciate the many facets and complex problems of oral bioavailability, including the basic barriers to oral bioavailability, the methods used to determine relevant parameters, and the challenges of drug delivery.In addition, this comprehensive book discusses biological and physicochemical methods for improving bioavailability, integrates physicochemistry with physiology and molecular biology, and includes several state-of-the-art technologies and approachesCaco-2 cell culture model, MDCK, and other related cell culture modelswhich are used to study the science of oral bioavailability.

Del 21 - Wiley Series in Drug Discovery and Development

Oral Bioavailability and Drug Delivery

From Basics to Advanced Concepts and Applications

AvMing Hu,Xiaoling Li

Inbunden, Engelska, 2024

3 105 kr

Skickas inom 5-8 vardagar

ORAL BIOAVAILABILITY AND DRUG DELIVERY Improve the performance and viability of newly-developed and approved drugs with this crucial guide Bioavailability is the parameter which measures the rate and extent to which a drug reaches a user’s circulatory system depending on the method of administration. For example, intravenous administration produces a bioavailability of 100%, since the drugs are injected directly into the circulatory system; in the case of oral administration, however, bioavailability can vary widely based on factors which, if not properly understood, can result in a failure in drug development, adverse effects, and other complications. The mechanics of oral bioavailability are therefore critical aspects of drug development. Oral Bioavailability and Drug Delivery provides a comprehensive coverage of this subject as well as its drug development applications. Beginning with basic terminology and fundamental concepts, it provides a thorough understanding of the challenges and barriers to oral bioavailability as well as the possibilities for improving this parameter. The resulting book is an indispensable tool for drug development research. Oral Bioavailability and Drug Delivery readers will also find: Discussion questions in many chapters to facilitate comprehensionDetailed discussion of topics including dissolution, absorption, metabolism, and moreReal-world examples of methods in actions throughoutOral Bioavailability and Drug Delivery is ideal for pharmaceutical and biotechnology scientists working in drug discovery and development; researchers in chemistry, biology, pharmacology, immunology, neuroscience, and other related fields; and graduate courses in drug development and delivery.

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Xiaoling Li – författare

Design of Controlled Release Drug Delivery Systems

Oral Bioavailability

Oral Bioavailability and Drug Delivery

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