Kanti Bhooshan Pandey, PhD, is a Senior Scientist and Assistant Professor in the Faculty of Biological Sciences, AcSIR; CSIR-Central Salt & Marine Chemicals Research Institute, Gujarat, India. Maitree Suttajit, PhD, is Professor Emeritus previously at School of Medicine, Chiang Mai University and later at School of Medical Sciences, University of Phayao, Thailand. Pinar Atukeren, PhD, is a senior Professor in Medical Biochemistry teaching in İstanbul Üniversitesi-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Medical Biochemistry, and also the Founding Dean of İstanbul Üniversitesi-Cerrahpaşa, Faculty of Pharmacy, Turkey.

• List of Contributors viiiPreface xiiPart I Fundamental Concepts of Diabetes Mellitus and Drug Discovery Process 11 Diabetes Mellitus and Natural Product-based Drug Discovery: Novel Directions 3David J. Newman2 Marine Natural Products in the Management of Diabetes Mellitus 18Murali Krishna Paidi, Kanchan Siddaprasad Udata, and Subir Kumar Mandal3 Carbohydrate-based Antidiabetic Agents from Natural Products 38Sandeep Singh4 Functional Foods in Clinical Trials in the Intervention of Diabetes Complications 49Bavani Arumugam and Umah Rani Kuppusamy5 Role of Nanotechnology in Refining the Antidiabetic Activities of Plant Derived Bioactives 74Sonam Mishra, Ravindra Dhar, Maitree Suttajit, and Bishnu Kumar PandeyPart II Bioactive Compounds Against Type 1 Diabetes Mellitus 976 Epidemiology and Genetics of Type 1 Diabetes Mellitus: The Effect of the Mediterranean Diet 99Bilge Nur Col and Muveddet Emel Alphan7 The Emerging Role of Plant Polyphenols in the Management of Type 1 Diabetes Mellitus 113S. Asha Devi, Suparna Mandal, and S. Raja Sekhar8 Bioactives as Modulators of β-cells and Immunity in Therapy of Type 1 Diabetes Mellitus 136Shashank Kumar Ojha9 Obesity in Type 1 Diabetes Mellitus: Clinical Impact and Nutritional Therapy 147Gülen Ecem Kalkan and Burcu Ateş Özcan10 Protective Effects of Natural Non-insulin Drugs against Type 1 Diabetes Mellitus 164Waseem Hassan, Faraza Javaid, Andleeb Shahzadi, and Sahar BakhtPart III Bioactive Compounds Against Type 2 Diabetes Mellitus 17711 Age-induced Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus: Role of Plant Polyphenols 179Brahm Kumar Tiwari and Kanti Bhooshan Pandey12 Bioactives from Clove Oil for Antibacterial Wound Dressings for the Treatment and Management of Wounds in Type 2 Diabetes Mellitus 195Andleeb Shahzadi and Haktan Sonmez13 Nutritional Features and Bioactivities of Thymoquinone against Type 2 Diabetes Mellitus 211Pınar Atukeren14 Effect of Resveratrol and Catechins in Maintaining Redox Homeostasis during Type 2 Diabetes Mellitus 219Prachee Dubey and Geeta Watal15 Cannabis: Action Mechanisms and Potential Roles in the Management of Type 2 Diabetes Mellitus 232Karolin Yanar and Zeynep Mine Coşkun YazıcıPart IV Gestational Diabetes: Prevention and Management by Natural Compounds 24516 Epidemiology of Gestational Diabetes Mellitus: Preventive Significance of Dietary Pattern 247Burcu Yeşilkaya17 Biomarkers of Gestational Diabetes Mellitus, Dietary Polyphenols, and Drug Discovery 260Mansi Gandhi18 Medicinal and Aromatic Plants in the Prevention of Gestational Diabetes and Associated Consequences: Current Insights 275Jigeesha Mishra, Kanti Bhooshan Pandey, and Shailendra Kumar Srivastava19 Enhancement of Insulin Sensitivity and Management of Lipid Disorders during Gestational Diabetes Mellitus: Role of Capsaicin 294Banu Orta-Yilmaz, Ahu Korkut, and Yasemin Aydin20 Effects of Natural Products on the Genetics of Gestational Diabetes Mellitus 308Onur BaykaraIndex 321

Kanti Bhooshan Pandey, PhD, is a Senior Scientist and Assistant Professor in the Faculty of Biological Sciences, AcSIR; CSIR-Central Salt & Marine Chemicals Research Institute, Gujarat, India. Maitree Suttajit, PhD, is Professor Emeritus previously at School of Medicine, Chiang Mai University and later at School of Medical Sciences, University of Phayao, Thailand. Pinar Atukeren, PhD, is a senior Professor in Medical Biochemistry teaching in İstanbul Üniversitesi-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Medical Biochemistry, and also the Founding Dean of İstanbul Üniversitesi-Cerrahpaşa, Faculty of Pharmacy, Turkey.

• List of Contributors viiiPreface xiiPart I Fundamental Concepts of Diabetes Mellitus and Drug Discovery Process 11 Diabetes Mellitus and Natural Product-based Drug Discovery: Novel Directions 3David J. Newman2 Marine Natural Products in the Management of Diabetes Mellitus 18Murali Krishna Paidi, Kanchan Siddaprasad Udata, and Subir Kumar Mandal3 Carbohydrate-based Antidiabetic Agents from Natural Products 38Sandeep Singh4 Functional Foods in Clinical Trials in the Intervention of Diabetes Complications 49Bavani Arumugam and Umah Rani Kuppusamy5 Role of Nanotechnology in Refining the Antidiabetic Activities of Plant Derived Bioactives 74Sonam Mishra, Ravindra Dhar, Maitree Suttajit, and Bishnu Kumar PandeyPart II Bioactive Compounds Against Type 1 Diabetes Mellitus 976 Epidemiology and Genetics of Type 1 Diabetes Mellitus: The Effect of the Mediterranean Diet 99Bilge Nur Col and Muveddet Emel Alphan7 The Emerging Role of Plant Polyphenols in the Management of Type 1 Diabetes Mellitus 113S. Asha Devi, Suparna Mandal, and S. Raja Sekhar8 Bioactives as Modulators of β-cells and Immunity in Therapy of Type 1 Diabetes Mellitus 136Shashank Kumar Ojha9 Obesity in Type 1 Diabetes Mellitus: Clinical Impact and Nutritional Therapy 147Gülen Ecem Kalkan and Burcu Ateş Özcan10 Protective Effects of Natural Non-insulin Drugs against Type 1 Diabetes Mellitus 164Waseem Hassan, Faraza Javaid, Andleeb Shahzadi, and Sahar BakhtPart III Bioactive Compounds Against Type 2 Diabetes Mellitus 17711 Age-induced Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus: Role of Plant Polyphenols 179Brahm Kumar Tiwari and Kanti Bhooshan Pandey12 Bioactives from Clove Oil for Antibacterial Wound Dressings for the Treatment and Management of Wounds in Type 2 Diabetes Mellitus 195Andleeb Shahzadi and Haktan Sonmez13 Nutritional Features and Bioactivities of Thymoquinone against Type 2 Diabetes Mellitus 211Pınar Atukeren14 Effect of Resveratrol and Catechins in Maintaining Redox Homeostasis during Type 2 Diabetes Mellitus 219Prachee Dubey and Geeta Watal15 Cannabis: Action Mechanisms and Potential Roles in the Management of Type 2 Diabetes Mellitus 232Karolin Yanar and Zeynep Mine Coşkun YazıcıPart IV Gestational Diabetes: Prevention and Management by Natural Compounds 24516 Epidemiology of Gestational Diabetes Mellitus: Preventive Significance of Dietary Pattern 247Burcu Yeşilkaya17 Biomarkers of Gestational Diabetes Mellitus, Dietary Polyphenols, and Drug Discovery 260Mansi Gandhi18 Medicinal and Aromatic Plants in the Prevention of Gestational Diabetes and Associated Consequences: Current Insights 275Jigeesha Mishra, Kanti Bhooshan Pandey, and Shailendra Kumar Srivastava19 Enhancement of Insulin Sensitivity and Management of Lipid Disorders during Gestational Diabetes Mellitus: Role of Capsaicin 294Banu Orta-Yilmaz, Ahu Korkut, and Yasemin Aydin20 Effects of Natural Products on the Genetics of Gestational Diabetes Mellitus 308Onur BaykaraIndex 321