Principles of Biochemistry

Laurence A. MoranAfter earning his Ph.D from Princeton University in 1974, Professor Moran spent four years at the Université dè Geneve in Switzerland. He has been a member of the Department of Biochemistry at the University of Toronto since 1978, specializing in molecular biology and molecular evolution. His research findings on heat-shock genes have been published in many scholarly journals.H. Robert HortonDr. Horton, who received his Ph.D from the University of Missouri in 1962, is William Neal Reynolds Professor Emeritus and Alumni Distinguished Professor Emeritus in the Department of Biochemistry at North Carolina State University, where he served on the faculty for over 30 years. Most of Professor Horton’s research was in protein and enzyme mechanisms.K. Gray ScrimgeourProfessor Scrimgeour received his doctorate from the University of Washington in 1961 and has been a faculty member at the University of Toronto since 1967. He is the author of The Chemistry and Control of Enzymatic Reactions (1977, Academic Press), and his work on enzymatic systems has been published in more than 50 professional journal articles during the past 40 years. From 1984—1992, he was editor of the journal Biochemistry and Cell Biology.Marc D. PerryAfter earning his Ph.D. from the University of Toronto in 1988, Dr. Perry trained at the University of Colorado, where he studied sex determination in the nematode C. elegans. In 1994 he returned to the University of Toronto as a faculty member in the department of Molecular and Medical Genetics. His research has focused on developmental genetics, meiosis and bioinformatics. In 2004 he joined the Heart & Stroke / Richard Lewar Centre of Excellence in Cardiovascular Research in the University of Toronto’s Faculty of Medicine.

• Part One: Introduction 1 Introduction to Biochemistry2 WaterPart Two: Structure and Function 3 Amino Acids and the Primary Structures of Proteins4 Proteins: Three-Dimensional Structure and Function5 Properties of Enzymes6 Mechanisms of Enzymes7 Carbohydrates8 Coenzymes and Vitamins9 Lipids and MembranesPart Three: Metabolism and Bioenergetics 10 Introduction to Metabolism11 Glycolysis12 Gluconeogenesis, The Pentose Phosphate Pathway, and Glycogen Metabolism13 The Citric Acid Cycle14 Electron Transport and ATP Synthesis15 Photosynthesis16 Lipid Metabolism17 Amino Acid Metabolism18 Nucleotide MetabolismPart Four: Biological Information Flow 19 Nucleic Acids20 DNA Replication, Repair, and Recombination21 Transcription and RNA Processing22 Protein Synthesis