Rocío Fernández-Ballesteros is Emeritus Professor in the Department of Psychobiology and Health at the Universidad Autónoma de Madrid. She has been searching and promoting healthy and active aging since 1980. Throughout her career she has served as a consultant to UNESCO, the United Nations, the World Health Organization, and the European Union. Athanase Benetos is Professor of Geriatric Medicine and Biology of Aging at the University of Lorraine. He has published more than 360 papers in peer-reviewed international scientific journals and participated in several scientific books. He is the President Elect of the European Geriatric Medicine Society (EUGMS). Jean-Marie Robine is the Research Director at INSERM, the French National Institute of Health and Medical Research. He is also a professor at the advanced school Ecole pratique des hautes études (EPHE) in Paris. Since its creation in 1989, he has also been the coordinator of the International Network on Health Expectancy (REVES).

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• Introduction: some traits about this Handbook of Successful Aging Rocío Fernández-Ballesteros, Jean-Marie Robine and Athanase Benetos; 1. The concept of successful aging and related terms Rocío Fernández-Ballesteros; 2. The biomedical bases of successful aging Athanase Benetos; 3. Successful aging and the longevity revolution Jean-Marie Robine; Part I. Biomedical: 4. The connection between cellular senescence and age-related diseases Claire Falandry; 5. From inflamm-aging to immunosenescence Tamàs Fulop, Jacek M. Witkowski, Alan A. Cohen, Gilles Dupuis, Katsuiku Hirokawa and Anis Larbi; 6. Telomere dynamics and aging related diseases Simon Toupance and Athanase Benetos; 7. Gene-lifestyle interactions in longevity Rune Lindahl-Jacobsen and Kaare Christensen; 8. Plasticity of the brain and cognition in older adults Kiyoka Kinugawa; 9. Arterial stiffness and blood pressure during the aging process Athanase Benetos, Magnus Bäck, Michel E. Safar and Harold Smulyan; 10. Prevention of frailty Bertrand Fougère and Matteo Cesari; 11. Preventive effects of physical activity in older people Timo E. Strandberg; 12. Nutrition and cognition Stany Perkisas and Maurits Vandewoude; 13. Nutrition, muscle function and mobility in older people Rebecca Diekmann and Juergen M. Bauer; 14. Gerontechnologies and successful aging Daniel Gillain, Sébastien Piccard, Christelle Boulanger and Jean Petermans; 15. Optimization of drug use in older people: a key factor for a successful aging Mirko Petrovic, Annemie Somers, Sophie Marien and Anne Spinewine; Part II. Psychosocial: 16. Bio-psycho-social bridge: the psychoneuroimmune system in successful aging Mónica De la Fuente; 17. The adaptation process of aging Jana Nikitin and Alexandra M. Freund; 18. Behavioral health Marta Santacreu, Marcos Alonso Rodríguez and María Ángeles Molina; 19. Effects of environmental enrichment and training across life span in cognition María Dolores Calero; 20. Wisdom: the royal road to personality growth Ute Kunzmann; 21. Emotions and successful aging Constança Paúl; 22. Personal control and successful aging Katherine E. Bercovitz, Christelle Ngnoumen and Ellen J. Langer; 23. Coping mechanisms through successful aging María Márquez-González, Sheung-Tak Cheng and Andrés Losada; 24. Spirituality and transcendence Andreas Kruse and Eric Schmitt; 25. Intergenerational family relationships and successful aging Ariela Lowenstein, Ruth Katz and Aviad Tur-Sinai; 26. Involvement with life and social networks: a pathway for successful aging Toni C. Antonucci and Noah J. Webster; 27. Defining 'success' in exceptional longevity Oscar Ribeiro and Lia Araújo; 28. Promoting successful aging: a psychosocial perspective Maria Giovanna Caprara and Neyda Ma. Mendoza-Ruvalcaba; 29. Promoting successful aging in the community Víctor Manuel Mendoza-Núñez and María de la Luz Martínez-Maldonado; Part III. Socio-Demography: 30. The promise of active aging Alan Walker; 31. Linking the socio-physical environment to successful aging: from basic research to intervention to implementation science considerations Hans-Werner Wahl and Laura N. Gitlin; 32. The active aging index: measuring successful aging at population level Azghar Zaidi and Marge Unt; 33. Aging and capabilities Catherine Le Galès.