Molecular Hematology

DREW PROVAN MD, FRCP, FRCPATH, Emeritus Reader in Autoimmune Hematology, Centre for Immunology, Blizard Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK. HILLARD M. LAZARUS, MD, FACP, Professor of Hematology-Oncology, Full Professor of Medicine, The Department of Medicine, Division of Hematology-Oncology, Case Western Reserve University, Cleveland, Ohio 44106.

• List of contributors ixForeword xiiiPreface xv1 Beginnings: the molecular pathology of hemoglobin 1Douglas Higgs and Mohsin Badat2 Stem cells 17David T. Scadden3 The genetics of acute myeloid leukemia 33Amye M. Harrigan and Amy M. Trottier4 Molecular diagnostics and risk assessment in myeloid malignancies 51Christian Scharenberg and Torsten Haferlach5 Molecular basis of acute lymphoblastic leukemia 67Shunsuke Kimura and Charles G. Mullighan6 Chronic myelogenous leukemia 83Hagop Kantarjian, Elias Jabbour and Susan O’Brien7 Myeloproliferative neoplasms 99Jessica Spiers, Dina Mahdi, Christopher Saunders and Donal P. McLornan8 Lymphoma genetics 113Giovanni Insuasti- Beltran, Chad M. McCall and Eric D. Hsi9 Molecular basis of chronic lymphocytic leukemia 127Bita Fakhri and Alexey Danilov10 The molecular biology of multiple myeloma 137Udit Yadav and Wilson I. Gonsalves11 The molecular basis of bone marrow failure syndromes and red cell enzymopathies 145Deena Iskander, Lucio Luzzatto and Anastasios Karadimitris12 Anemia of chronic disease 169Tomas Ganz and Elizabeta Nemeth13 Molecular basis of iron metabolism 175Jodie L. Babitt and Tomas Ganz14 Perspectives in genomics and sickle cell disease therapeutics 187Ambroise Wonkam15 Molecular coagulation and thrombophilia 201Björn Dahlbäck and Andreas Hillarp16 The molecular basis of hemophilia 217Keith Gomez17 The molecular basis of von Willebrand disease 231Omid Seidizadeh and Luciano Baronciani18 Platelet disorders 251Kenneth J. Clemetson19 The molecular basis of blood cell alloantigens 267Winnie Chong, Louise Tilley and Colin Brown20 Functions of blood group antigens 285Jonathan S. Stamler, Marilyn J. Telen and Carla Dinardo21 Autoimmune hematological disorders 299Drew Provan and John W. Semple22 Molecular therapeutics in hematology: gene therapy 321William M. McKillop and Jeffrey A. Medin23 Pharmacogenomics 343Leo Kager and William E. Evans24 Cancer stem cells 359Sara Ali and Dominique Bonnet25 CAR- T cell therapy 369Jude Franklin, Prateek Pophali, Zachary Jackson, David Wald and David Avigan26 Molecular basis of transplantation 397Pramila Krishnamurthy, Victoria Potter and Francesco DazziIndex 413