Mukul Jain, PhD is a Professor in the Research and Development Cell at Parul University. He has published more than 60 book chapters and articles in international journals and conferences. His research interests include gel electrophoresis, DNA extraction, and cloning. Mohd. Tariq, PhD is a Professor in the Department of Life Sciences at the Parul Institute of Applied Sciences. He has more than 85 publications to his credit, including two books, book chapters, and articles in international journals and conferences. His research focuses on conservation biology and ecology, biodiversity monitoring, and habitat selection. Arifullah Mohammed, PhD is an Associate Professor in the Department of Agriculture Science in the School of Agro-Based Industry at the Universiti Malaysia Kelantan. He has published more than 50 book chapters and articles in international journals and conferences. His research interests include plant biotechnology, medicinal plants, and pharmacognosy. Ayush Madan is a Professor in the Department of Biotechnology in the School of Research and Technology at the People’s University. He has more than 100 publications to his credit, including a patent, five books, book chapters, and articles in international journals and conferences.

• Preface xxv1 Introduction to Plant-Derived Neurotherapeutics: An Overview of Secondary Metabolites 1Koushik Das, Yukti Mittal, Injamamul Haque and Zuber Khan2 Phytochemistry of Neuroprotective Compounds: Key Classes and Their Properties 47Baskaran Gunasekaran, Saema Hanafi, Kirtana Devi and Vaidehi Ulaganathan3 Mechanisms of Action: How Plant Metabolites Interact with Neurological Pathways 97Nil Patil, Urvi Patil, Mukul Jain, Ayush Madan and Mohd. Tariq4 Antioxidant Pathways: Combating Oxidative Stress in the Brain 119Annu Verma, D.S.N.B.K. Prasanth and Ashwini Deshpande5 Anti-Inflammatory Effects of Plant Metabolites on Neurological Health 155Ahmed H. Elosaily, Ahmed M. El-Dessouki, Riham A. El-Shiekh, Mohamed S. Abd El Hafeez, Ghadir A. Sayed and Noha M. Gamil6 Modulating Neurotransmitter Systems: Plant Compounds in Cognitive Enhancement 189Reshma Tendulkar and Mugdha Tendulkar7 Promoting Neurogenesis and Neuroplasticity: Potential for Brain Regeneration 217Vivek Sharma, Tanuja Sharma, Naveen Singh, Rajnish Srivastava and Naresh Kumar Rangra8 Alzheimer's Disease and Phytochemicals: Mechanisms and Potential Treatments 247Shaik Ibrahim Khalivulla, Arifullah Mohammed and Saeed Alshahrani9 Parkinson's Disease: Plant Derived Therapeutics and Dopaminergic Support 267Naveen Singh, Namita Aggarwal, Nitin Verma and Rajnish Srivastava10 Huntington's and Other Neurodegenerative Disorders: Plant-Based Interventions 305Mukul Jain, Rupal Dhariwal, Akangsha Lahon, Ritika Bhardwaj and Krishna Thakkar11 Mental Health Disorders: Phytochemical Approaches to Anxiety, Depression, and Stress 343Mohd Farhan, Mohd Faisal, Asim Rizvi, Ghazala Muteeb, Mohammad Aatif and Mir Waqas Alam12 Bioavailability and Pharmacokinetics of Plant Metabolites in Neurotherapeutics 391Himanshu Jain and Neeraj K. Aggarwal13 Formulation and Delivery Systems for Brain-Targeted Phytochemicals 435Unmesh Gulabrao Bhamare, Prakash Pannalal Muleva, Deepali Dattatray Bhandari, Ramanlal Narayan Kachave, Sunil Vishvnath Amrutkar and Dattatraya Manohar Shinkar14 Preclinical and Clinical Studies: Evidence Supporting Plant Neurotherapeutics 469Nisha Vijayan Kalayil, Sahaya Nadar, Ekta Thakor and Jegan Nadar15 Plant-Based Brain Therapies: Challenges and Future Prospects Along with Molecular Mechanism Aided in Cognitive Protection 511K.R. Padma, K.R. Don, M. Sankari, K. Harathi and N. Sandhya16 Traditional and Modern Uses of Plants in Neurotherapy—A Comparative Perspective 561Laxmi, Rahul Sharma, Shriyansh Srivastava, Izaz Hussain and Rakesh Sahu17 Case Studies of Plant Extracts in Neurotherapeutics Formulations 591Erum Khalid, Sudhair Alam, Feroza Hamid Wattoo, Muhammad Javaid Asad, Saima Amin and Muhammad Gulfaraz18 Future Trends in Plant-Derived Neurotherapeutics: From Lab to Clinic 609Ananda Kumar Chettupalli, Mustapha, S.K. Abdual Rahaman, Neha Gupta, Garlapati Vijay Kumar and Sarad Pawar Naik BukkeReferences 637Index 645

Mukul Jain, PhD is a Professor in the Research and Development Cell at Parul University. He has published more than 60 book chapters and articles in international journals and conferences. His research interests include gel electrophoresis, DNA extraction, and cloning. Mohd. Tariq, PhD is a Professor in the Department of Life Sciences at the Parul Institute of Applied Sciences. He has more than 85 publications to his credit, including two books, book chapters, and articles in international journals and conferences. His research focuses on conservation biology and ecology, biodiversity monitoring, and habitat selection. Arifullah Mohammed, PhD is an Associate Professor in the Department of Agriculture Science in the School of Agro-Based Industry at the Universiti Malaysia Kelantan. He has published more than 50 book chapters and articles in international journals and conferences. His research interests include plant biotechnology, medicinal plants, and pharmacognosy. Ayush Madan is a Professor in the Department of Biotechnology in the School of Research and Technology at the People’s University. He has more than 100 publications to his credit, including a patent, five books, book chapters, and articles in international journals and conferences.

• Preface xxv1 Introduction to Plant-Derived Neurotherapeutics: An Overview of Secondary Metabolites 1Koushik Das, Yukti Mittal, Injamamul Haque and Zuber Khan2 Phytochemistry of Neuroprotective Compounds: Key Classes and Their Properties 47Baskaran Gunasekaran, Saema Hanafi, Kirtana Devi and Vaidehi Ulaganathan3 Mechanisms of Action: How Plant Metabolites Interact with Neurological Pathways 97Nil Patil, Urvi Patil, Mukul Jain, Ayush Madan and Mohd. Tariq4 Antioxidant Pathways: Combating Oxidative Stress in the Brain 119Annu Verma, D.S.N.B.K. Prasanth and Ashwini Deshpande5 Anti-Inflammatory Effects of Plant Metabolites on Neurological Health 155Ahmed H. Elosaily, Ahmed M. El-Dessouki, Riham A. El-Shiekh, Mohamed S. Abd El Hafeez, Ghadir A. Sayed and Noha M. Gamil6 Modulating Neurotransmitter Systems: Plant Compounds in Cognitive Enhancement 189Reshma Tendulkar and Mugdha Tendulkar7 Promoting Neurogenesis and Neuroplasticity: Potential for Brain Regeneration 217Vivek Sharma, Tanuja Sharma, Naveen Singh, Rajnish Srivastava and Naresh Kumar Rangra8 Alzheimer's Disease and Phytochemicals: Mechanisms and Potential Treatments 247Shaik Ibrahim Khalivulla, Arifullah Mohammed and Saeed Alshahrani9 Parkinson's Disease: Plant Derived Therapeutics and Dopaminergic Support 267Naveen Singh, Namita Aggarwal, Nitin Verma and Rajnish Srivastava10 Huntington's and Other Neurodegenerative Disorders: Plant-Based Interventions 305Mukul Jain, Rupal Dhariwal, Akangsha Lahon, Ritika Bhardwaj and Krishna Thakkar11 Mental Health Disorders: Phytochemical Approaches to Anxiety, Depression, and Stress 343Mohd Farhan, Mohd Faisal, Asim Rizvi, Ghazala Muteeb, Mohammad Aatif and Mir Waqas Alam12 Bioavailability and Pharmacokinetics of Plant Metabolites in Neurotherapeutics 391Himanshu Jain and Neeraj K. Aggarwal13 Formulation and Delivery Systems for Brain-Targeted Phytochemicals 435Unmesh Gulabrao Bhamare, Prakash Pannalal Muleva, Deepali Dattatray Bhandari, Ramanlal Narayan Kachave, Sunil Vishvnath Amrutkar and Dattatraya Manohar Shinkar14 Preclinical and Clinical Studies: Evidence Supporting Plant Neurotherapeutics 469Nisha Vijayan Kalayil, Sahaya Nadar, Ekta Thakor and Jegan Nadar15 Plant-Based Brain Therapies: Challenges and Future Prospects Along with Molecular Mechanism Aided in Cognitive Protection 511K.R. Padma, K.R. Don, M. Sankari, K. Harathi and N. Sandhya16 Traditional and Modern Uses of Plants in Neurotherapy—A Comparative Perspective 561Laxmi, Rahul Sharma, Shriyansh Srivastava, Izaz Hussain and Rakesh Sahu17 Case Studies of Plant Extracts in Neurotherapeutics Formulations 591Erum Khalid, Sudhair Alam, Feroza Hamid Wattoo, Muhammad Javaid Asad, Saima Amin and Muhammad Gulfaraz18 Future Trends in Plant-Derived Neurotherapeutics: From Lab to Clinic 609Ananda Kumar Chettupalli, Mustapha, S.K. Abdual Rahaman, Neha Gupta, Garlapati Vijay Kumar and Sarad Pawar Naik BukkeReferences 637Index 645

Mukul Jain, PhD is a Professor in the Research and Development Cell at Parul University. He has published more than 60 book chapters and articles in international journals and conferences. His research interests include gel electrophoresis, DNA extraction, and cloning. Mohd. Tariq, PhD is a Professor in the Department of Life Sciences at the Parul Institute of Applied Sciences. He has more than 85 publications to his credit, including two books, book chapters, and articles in international journals and conferences. His research focuses on conservation biology and ecology, biodiversity monitoring, and habitat selection. Arifullah Mohammed, PhD is an Associate Professor in the Department of Agriculture Science in the School of Agro-Based Industry at the Universiti Malaysia Kelantan. He has published more than 50 book chapters and articles in international journals and conferences. His research interests include plant biotechnology, medicinal plants, and pharmacognosy. Ayush Madan is a Professor in the Department of Biotechnology in the School of Research and Technology at the People’s University. He has more than 100 publications to his credit, including a patent, five books, book chapters, and articles in international journals and conferences.

• Preface xxv1 Introduction to Plant-Derived Neurotherapeutics: An Overview of Secondary Metabolites 1Koushik Das, Yukti Mittal, Injamamul Haque and Zuber Khan2 Phytochemistry of Neuroprotective Compounds: Key Classes and Their Properties 47Baskaran Gunasekaran, Saema Hanafi, Kirtana Devi and Vaidehi Ulaganathan3 Mechanisms of Action: How Plant Metabolites Interact with Neurological Pathways 97Nil Patil, Urvi Patil, Mukul Jain, Ayush Madan and Mohd. Tariq4 Antioxidant Pathways: Combating Oxidative Stress in the Brain 119Annu Verma, D.S.N.B.K. Prasanth and Ashwini Deshpande5 Anti-Inflammatory Effects of Plant Metabolites on Neurological Health 155Ahmed H. Elosaily, Ahmed M. El-Dessouki, Riham A. El-Shiekh, Mohamed S. Abd El Hafeez, Ghadir A. Sayed and Noha M. Gamil6 Modulating Neurotransmitter Systems: Plant Compounds in Cognitive Enhancement 189Reshma Tendulkar and Mugdha Tendulkar7 Promoting Neurogenesis and Neuroplasticity: Potential for Brain Regeneration 217Vivek Sharma, Tanuja Sharma, Naveen Singh, Rajnish Srivastava and Naresh Kumar Rangra8 Alzheimer's Disease and Phytochemicals: Mechanisms and Potential Treatments 247Shaik Ibrahim Khalivulla, Arifullah Mohammed and Saeed Alshahrani9 Parkinson's Disease: Plant Derived Therapeutics and Dopaminergic Support 267Naveen Singh, Namita Aggarwal, Nitin Verma and Rajnish Srivastava10 Huntington's and Other Neurodegenerative Disorders: Plant-Based Interventions 305Mukul Jain, Rupal Dhariwal, Akangsha Lahon, Ritika Bhardwaj and Krishna Thakkar11 Mental Health Disorders: Phytochemical Approaches to Anxiety, Depression, and Stress 343Mohd Farhan, Mohd Faisal, Asim Rizvi, Ghazala Muteeb, Mohammad Aatif and Mir Waqas Alam12 Bioavailability and Pharmacokinetics of Plant Metabolites in Neurotherapeutics 391Himanshu Jain and Neeraj K. Aggarwal13 Formulation and Delivery Systems for Brain-Targeted Phytochemicals 435Unmesh Gulabrao Bhamare, Prakash Pannalal Muleva, Deepali Dattatray Bhandari, Ramanlal Narayan Kachave, Sunil Vishvnath Amrutkar and Dattatraya Manohar Shinkar14 Preclinical and Clinical Studies: Evidence Supporting Plant Neurotherapeutics 469Nisha Vijayan Kalayil, Sahaya Nadar, Ekta Thakor and Jegan Nadar15 Plant-Based Brain Therapies: Challenges and Future Prospects Along with Molecular Mechanism Aided in Cognitive Protection 511K.R. Padma, K.R. Don, M. Sankari, K. Harathi and N. Sandhya16 Traditional and Modern Uses of Plants in Neurotherapy—A Comparative Perspective 561Laxmi, Rahul Sharma, Shriyansh Srivastava, Izaz Hussain and Rakesh Sahu17 Case Studies of Plant Extracts in Neurotherapeutics Formulations 591Erum Khalid, Sudhair Alam, Feroza Hamid Wattoo, Muhammad Javaid Asad, Saima Amin and Muhammad Gulfaraz18 Future Trends in Plant-Derived Neurotherapeutics: From Lab to Clinic 609Ananda Kumar Chettupalli, Mustapha, S.K. Abdual Rahaman, Neha Gupta, Garlapati Vijay Kumar and Sarad Pawar Naik BukkeReferences 637Index 645