Enantiomer Separation

Fundamentals and Practical Methods

Inbunden, Engelska, 2005

1 589 kr

Beställningsvara. Skickas inom 10-15 vardagar. Fri frakt över 249 kr.

Beskrivning

Many important pharmaceutical drugs, chemicals for the organic synthesis of chiral compounds, electronic elements such as liquid crystals, and polymeric materials are chiral (enantiomeric). The development of new practical methods for the preparation of enantiomerically pure substances is thus vital. Enantiomer Separation is written by several experts working in modern enantiomer separation chemistry who understand the needs of the many scientific and engineering chemists who need a cost-efficient supply of optically active materials of high quality. This book contains the following modern practical methods of enantiomer separation: Practical methods of enantiomer separation are important both in the research laboratory and in industry, especially in the pharmaceutical, fine chemical and electronic industries. Chemists and engineers, as well as students who are working in the field of chiral compounds in universities, institute and industry, will find this book an invaluable resource.

Produktinformation

Utgivningsdatum:2005-01-27
Mått:210 x 297 x 18 mm
Vikt:739 g
Format:Inbunden
Språk:Engelska
Antal sidor:333
Upplaga:2004
Förlag:Springer-Verlag New York Inc.
ISBN:9781402023361

Utforska kategorier

Tillverkningsteknik inom Naturvetenskap och teknik

Recensioner i media

From the reviews: "This is an authoritative account of ... the methods applicable to the large-scale separation of enantiomers, edited by a leading authority on inclusion complexation using crystalline chiral host molecules ... . the basic science of enantiomer separation is well documented. The text is clearly printed ... . this book does provide accurate and detailed information on recently emerging techniques, and should be very useful to development chemists and scale-up scientists requiring access to single enantiomers on the multi-gram scale." (D. R. Taylor, Chromatographia, Vol. 63 (5-6), 2006) "This book covers enantiomer separation, with an emphasis on separation by chiral inclusion complexes and crystallization, biological methods ... as well as preparative liquid and gas chromatographic methods. ... this book succeeds in covering the practical methods for separating enantiomers on a preparative scale. ... it can be recommended as a resource for those working in the field of enantiomer separation, especially enzymatic resolutions, the practical aspects of crystallization, and preparative scale chromatography techniques." (Thomas K. Green, Journal of the American Chemical society, Vol. 128 (5), 2006)

Innehållsförteckning

Optical resolutions by inclusion complexation with a chiral host compound.- Crystalline dipeptides: their molecular recognition to be useful to enantiomer separation.- Optical resolution via complex formation with O,O'-dibenzoyltataric acid.- Spontaneous chiral crystallization of achiral materials and absolute asymmetric transformation in the chiral crystalline environment.- Preferential enrichment: a dynamic enantiomeric resolution phenomenon caused by polymorphic transition during crystallization.- Optical resolution by means of crystallization.- Lipase-catalyzed kinetic resolution of racemates: a versatile method for the separation of enantiomers.- Enzymatic kinetic resolution.- Preparative-scale separation of enantiomers on chiral stationary phases by gas chromatography.- Practical resolution of enantiomers by high-performance liquid chromatography.