"Skeletal metastases are both a common and devastating consequence of a spectrum of cancers. Significant advances have occurred in our understanding of the pathobiology of this process. This text provides a comprehensive review of current investigative findings and their clinical implications." (Steven T. Rosen, M.D. Series Editor)

• 1. The Basic Biology of Metastasis.- 2. Clinical Aspects of Bone Metastases in Prostate Cancer.- 3. Animal Models of Bone Metastasis.- 4. MIP-1 Alpha and Myeloma Bone Disease.- 5. Type I Collagen-Mediated Changes in Gene Expression and Function of Prostate Cancer Cells.- 6. PTHRP and Skeletal Metatasis.- 7. OPG, RANKL, and RANK In Cancer Metastasis: Expression and Regulation.- 8. Matrix Metalloproteinaess and Bone Metastasis.- 9. Endothelins in Bone Cancer Metastases.- 10. Bisphosphonate Actions on Bone and Visceral Metastases.- 11. Gene Therapy for Prostate Cancer Bone Metastasis.- 12. Cancer Cells Homing to Bone: The Significance of Chemotaxis and Cell Adhesion.- 13. Histological, Immunophenotypic and Histomorphometric Characterization of Prostate Cancer Bone Metastases.

"Skeletal metastases are both a common and devastating consequence of a spectrum of cancers. Significant advances have occurred in our understanding of the pathobiology of this process. This text provides a comprehensive review of current investigative findings and their clinical implications." (Steven T. Rosen, M.D. Series Editor)

• 1. The Basic Biology of Metastasis.- 2. Clinical Aspects of Bone Metastases in Prostate Cancer.- 3. Animal Models of Bone Metastasis.- 4. MIP-1 Alpha and Myeloma Bone Disease.- 5. Type I Collagen-Mediated Changes in Gene Expression and Function of Prostate Cancer Cells.- 6. PTHRP and Skeletal Metatasis.- 7. OPG, RANKL, and RANK In Cancer Metastasis: Expression and Regulation.- 8. Matrix Metalloproteinaess and Bone Metastasis.- 9. Endothelins in Bone Cancer Metastases.- 10. Bisphosphonate Actions on Bone and Visceral Metastases.- 11. Gene Therapy for Prostate Cancer Bone Metastasis.- 12. Cancer Cells Homing to Bone: The Significance of Chemotaxis and Cell Adhesion.- 13. Histological, Immunophenotypic and Histomorphometric Characterization of Prostate Cancer Bone Metastases.

"Skeletal metastases are both a common and devastating consequence of a spectrum of cancers. Significant advances have occurred in our understanding of the pathobiology of this process. This text provides a comprehensive review of current investigative findings and their clinical implications." (Steven T. Rosen, M.D. Series Editor)

• 1. The Basic Biology of Metastasis.- 2. Clinical Aspects of Bone Metastases in Prostate Cancer.- 3. Animal Models of Bone Metastasis.- 4. MIP-1 Alpha and Myeloma Bone Disease.- 5. Type I Collagen-Mediated Changes in Gene Expression and Function of Prostate Cancer Cells.- 6. PTHRP and Skeletal Metatasis.- 7. OPG, RANKL, and RANK In Cancer Metastasis: Expression and Regulation.- 8. Matrix Metalloproteinaess and Bone Metastasis.- 9. Endothelins in Bone Cancer Metastases.- 10. Bisphosphonate Actions on Bone and Visceral Metastases.- 11. Gene Therapy for Prostate Cancer Bone Metastasis.- 12. Cancer Cells Homing to Bone: The Significance of Chemotaxis and Cell Adhesion.- 13. Histological, Immunophenotypic and Histomorphometric Characterization of Prostate Cancer Bone Metastases.