Mark A. Crowther, MD, MSc, FRCPC McMaster University, Hamilton, Ontario, Canada Jeff Ginsberg, MD, FRCPC, McMaster University, Hamilton, Ontario, Canada Holger J. Schünemann, MD, PhD, MSc, FACP, FCCP, Italian National Cancer Institute, Rome, Italy Ralph M. Meyer, MD, FRCPC Queen's University, Kingston, Ontario, Canada Richard Lottenberg, MD, FACP, University of Florida, Gainesville, FL, USA

"This book is an excellent collection of current best practices in hematology. It should appeal to all who have to deal with everyday challenges in blood diseases." (Journal of Tropical Pediatrics, June 2009)

• List of Contributors viiPreface xiPart 1 A Guide to the EvidenceEditor: Holger J. Schünemann1 Rating the Quality of Evidence and Making Recommendations: A Guide to the Spectrum of Clinical Research 3Holger J. Schünemann, Martin Stanulla, Jan L. Brozek, Gordon G. Guyatt2 An Overview of Systematic Reviews 10Martin Prins, Arina ten Cate-Hoek, Pieter Leffers3 Interpreting Results in Clinical Research: Overview of measures of effect, measures of precision, and measures of diagnostic accuracy for clinicians and researchers 15Marcello Di Nisio, Harry R. Büller, Patrick M. M. Bossuyt4 Finding the Evidence in Hematology 23K. Ann McKibbon, Cynthia J. Walker-Dilks, R. Brian Haynes5 Applying EBM in Clinical Practice 32Alessandro Squizzato, Walter Ageno, Davide Imberti6 Using Evidence to Guide the Diagnosis of Disease 37Lucas M. Bachmann, Holger J. SchünemannPart 2 Hemostasis and ThrombosisEditor: Jeff Ginsberg7 Diagnosis of Deep Vein Thrombosis 49Lori-Ann Linkins8 The Diagnosis of Acute Pulmonary Embolism 56Victor F. Tapson9 Initial Therapy of Deep Vein Thrombosis and Pulmonary Embolism 65Sam Schulman10 Long-Term Anticoagulation in Venous Thromboembolism 73Clive Kearon11 Thrombolytic Therapy for Deep Vein Thrombosis and Pulmonary Embolism 88Simon J. McRae, John W. Eikelboom12 Inferior Vena Cava Interruption 99Michael B. Streiff, Christine L. Hann13 Management of Venous Thromboembolism in Pregnancy 110Wee-Shian Chan14 Pediatric Thrombosis 120Anthony K. C. Chan, Paul Monagle15 Bridging Anticoagulation in Patients Who Require Temporary Interruption of Warfarin for Surgery 124James D. Douketis, Scott Kaatz16 Evidence-based Approach to the Diagnosis and Management of Thrombotic Thrombocytopenic Purpura 131Brian Boulmay, Craig S. Kitchens17 Diagnosis and Management of Disseminated Intravascular Coagulation 138Julia A. M. Anderson18 Diagnosis and Management of Hereditary Bleeding Disorders: Including Congenital/Acquired Platelet Function Disorders 145Nigel S. Key, Alice D. Ma19 Diagnosis and Management of Acquired Bleeding Disorders: Vitamin K Antagonists 152Miguel A. Escobar20 Diagnosis and Management of Heparin-Induced Thrombocytopenia 158Theodore E. Warkentin, Andreas Greinacher21 Management of Antiphospholipid Antibody Syndrome 168Wendy Lim, Mark A. CrowtherPart 3 Benign Hematologic DisordersEditor: Richard Lottenberg22 Clinical Questions in Iron Overload 179Antonello Pietrangelo, Nicola Magrini23 Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, and Pure Red Cell Aplasia 189Shivani Srivastava, Richard W. Childs24 Acquired Anemias: Iron Deficiency, Cobalamin Deficiency, and Autoimmune Hemolytic Anemia 197Marc S. Zumberg, Marc J. Kahn25 Immune Thrombocytopenic Purpura 206James N. George, Sara K. Vesely, George R. Buchanan26 Neutropenia 215David C. Dale27 Hypereosinophilia: Primary and Secondary 221Florence Roufosse, Michel Goldman, Elie Cogan28 Porphyrias 229Gagan Sood, Karl E. Anderson29 Membrane and Enzyme Abnormalities of the Erythrocyte 238Patrick G. Gallagher, Ernest Beutler30 Sickle Cell Disease 244Richard Lottenberg, Sally C. Davies31 Evidence-based Treatment of Thalassemia Major 251Issac Odame, Deborah RundPart 4 Malignant Hematologic DisordersEditor: Ralph M. Meyer32 Acute Lymphoblastic Leukemia in Adults 263Stephen Couban, Andrea Kew33 Acute Myeloid Leukemia in Adults: Remission Induction Therapy 268Cara A. Rosenbaum, Richard A. Larson34 Acute Myeloid Leukemia in Adults: Postremission Therapy 278Cara A. Rosenbaum, Richard A. Larson35 Current Areas of Controversy in the Treatment of Patients With Newly Diagnosed Acute Promyelocytic Leukemia 287Martin S. Tallman, Syed A. Abutalib36 Chronic Lymphocytic Leukemia 294Bruce D. Cheson37 Chronic Myeloid Leukemia 300Irwin Walker38 Selected Management of Patients with Myelodysplastic Syndromes 305John M. Storring, Karen W. L. Yee39 Evidence-based Treatment of Burkitt Lymphoma in Adults 311John Gerecitano, David J. Straus40 Primary Central Nervous System Lymphoma 317Tamara Shenkier41 Diffuse Large B-cell Lymphoma 327Michael Crump42 Follicular Lymphoma 334Kevin Imrie, Matthew Cheung43 Lymphoblastic Lymphoma 342Tyler Y. Kang, John W. Sweetenham44 Mantle Cell Lymphoma 347C. Tom Kouroukis45 Management of Patients with Peripheral T-cell Lymphoma 352Kerry J. Savage46 Selected Management Issues of Patients with Hodgkin Lymphoma 365Ralph M. Meyer47 Lymphocyte Predominant Hodgkin Lymphoma 372Brandon McMahon, Jonathan W. Friedberg48 Management of Patients with Essential Thrombocythemia 378Guido Finazzi, Giovanni Barosi, Tiziano Barbui49 Management of Patients with Polycythemia Vera 385Guido Finazzi, Roberto Marchioli, Tiziano Barbui50 Evidence-based Review of Therapies in Multiple Myeloma 390Michael Sebag, A. Keith Stewart51 Management of Waldenstrom’s Macroglobulinemia 396Christine I. Chen52 The Role of Hematopoietic Growth Factors in Managing Patients with Hematologic Malignancies 402Heloisa P. Soares, Ambuj Kumar, Charles Bennett, Benjamin DjulbegovicIndex 413