Colors of Mice

A Model Genetic Network

Inbunden, Engelska, 2010

1 871 kr

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Beskrivning

Serving the needs of pigment cell biologists, cellular physiologists, developmental geneticists, researchers interested in melanoma and more, this new book showcases a blend of new technologies and new insights in the field of pigmantary genetics of mice, with comparative information on other animals. Graduate students can learn here the terminology and scope of the field, and animal fanciers can discover the genetics behind common color variants of mammals. The book is hailed for being written by four of the premier scientists in the field. These authors aim to present the molecular /cellular work in the context of phenotype and the interacting functions of genes that direct the development and function of one biological system. For other researchers, the depth of genetic knowledge on the pigmantary system makes it a valuable model for the study of other systems.

Produktinformation

Utgivningsdatum:2010-04-23
Mått:193 x 249 x 20 mm
Vikt:907 g
Format:Inbunden
Språk:Engelska
Antal sidor:320
Förlag:John Wiley and Sons Ltd
ISBN:9781405179546

Utforska kategorier

Däggdjur inom Naturvetenskap och teknik
Däggdjur inom Djur och Natur
Biovetenskap inom Naturvetenskap och teknik

Mer om författaren

Associated with our Pigment Cell Journal, the authors are of the highest stature in their fields. Lynn Lamoreux is a mouse geneticist well known for her work in pigment system. Dorothy Bennett is an expert on growth and biology of melanocytes while Dr. Larue is an expert on melanoma. together they are some of the most respected researchers in pigment cell biology

Innehållsförteckning

Preface viiAcknowledgments ixStatement regarding the use of pictures xStatement regarding nomenclature xiiPART I INTRODUCTION TO THE PIGMENTARY SYSTEM 11 Introduction to the Pigmentary System 31.1 Introduction 31.2 Colors of vertebrate animals 41.3 Other pigment cells 121.4 The epidermal melanin unit 121.5 Mammalian hair 131.6 Melanosome biogenesis and translocation 141.7 Melanin 151.8 Hair growth 151.9 Hair growth cycles 171.10 Embryonic development of the pigment cell lineage 181.11 Pigment cells in culture 181.12 Conclusion 19Appendix: color loci of the mouse 20PART II THE PIGMENTARY LOCI 492 Introduction to Mutant Pigmentary Genes 512.1 Defects of normal melanocyte development: white spotting and graying with age 512.2 Defects in normal melanosome development: albinism 522.3 Transport of melanosomes to other cells: the ‘dilute’ phenotype 532.4 Pigment-type switching: from eumelanogenesis to pheomelanogenesis 543 White Spotting and Progressive Graying 573.1 Definitions and general background 583.2 Pigment-cell development: developmental biology 623.3 Cellular signaling pathways for melanocytes 713.4 Pigment phenotypes and the classical white-spotting genes 883.5 The head, heart, ears, and eyes 1274 ‘Albinism’ and the Failure of Normal Melanosome Development 1324.1 Background 1334.2 The melanosomal matrix 1404.3 The enzymes that catalyze melanogenesis 1464.4 Membrane proteins that regulate the internal milieu of the melanosome 1534.5 Protein processing and routing to the maturing melanosome 1564.6 Melanosome transport 1715 Pigment-Type Switching 1775.1 Introduction 1785.2 Yellow phenotypes 1845.3 Melanin pigment 1895.4 Melanogenesis and the eumelanin/pheomelanin switch mechanism 1905.5 Signaling the switch mechanism at the cellular level 1925.6 Yellow genes 194PART III TECHNOLOGY AND RESOURCES 2076 Novel Mouse Pigmentary Mutants Generated byGenetic Manipulation 2096.1 Introduction 2096.2 Mouse transgenesis: generation of genetically engineered mice 2106.3 Coat-color transgenic mice 2196.4 The coat-color mutants generated by gene targeting 2246.5 Influence of the genetic background 2296.6 Conclusions 2307 Other Species and Other Resources 2327.1 Introduction 2327.2 Resources 2337.3 Other species 235References 243Index 286