Dr Ron Daniels MB ChB FRCAConsultant in Anaesthesia and Critical Care Lead Clinican, Critical Care Outreach, Good Hope Hospital, Birmingham, UKChair: Surviving Sepsis Campaign United Kingdom Steering Committee Survive SEPSIS Programme Director Dr Tim Nutbeam MB ChBTrainee in Emergency Medicine/Intensive Care MedicineEditor: Survive SEPSIS (the educational programme of the international Surviving Sepsis Campaign)

"The book's illustrations are superb. At the beginning of each chapter, an overview is presented, helping to succinctly outline the key points in the chapter. Tables and boxes are employed to outline key diagnostic and treatment points. There are a number of clinical pictures along with radiographic images to help highlight points of interest." (Journal of the Intensive Care Society, April 2010)

• Contributors viiPreface ix1 Introduction 1Mitchell M. Levy2 Defining the Spectrum of Disease 5Ron Daniels3 Identifying the Patient with Sepsis 10Ron Daniels4 Serious Complications of Sepsis 15Hentie Cilliers Tony Whitehouse and Bill Tunnicliffe5 The Pathophysiology of Sepsis 20Edwin Mitchell and Tony Whitehouse6 Initial Resuscitation 25Tim Nutbeam7 Microbiology and Antibiotic Therapy 29Partha De and Ron Daniels8 Infection Prevention and Control 36Fiona Lawrence Georgina McNamara and Clare Galvin9 The Role of Imaging in Sepsis 42Morgan Cleasby10 Presentations in Medical Patients 48Nandan Gautam11 Presentations in Surgical Patients 57Jonathan Stewart and Sian Abbott12 Special Cases: The Immunocompromised Patient 62Manos Nikolousis13 The Role of Critical Care 68Julian Hull14 Monitoring the Septic Patient 73David Stanley15 Novel Therapies in Sepsis 78Gavin D. Perkins and David R. Thickett16 Approaches to Achieve Change 83Julian F. Bion and Gordon D. RubenfieldIndex 87

Dr Ron Daniels MB ChB FRCAConsultant in Anaesthesia and Critical Care Lead Clinican, Critical Care Outreach, Good Hope Hospital, Birmingham, UKChair: Surviving Sepsis Campaign United Kingdom Steering Committee Survive SEPSIS Programme Director Dr Tim Nutbeam MB ChBTrainee in Emergency Medicine/Intensive Care MedicineEditor: Survive SEPSIS (the educational programme of the international Surviving Sepsis Campaign)

"The book's illustrations are superb. At the beginning of each chapter, an overview is presented, helping to succinctly outline the key points in the chapter. Tables and boxes are employed to outline key diagnostic and treatment points. There are a number of clinical pictures along with radiographic images to help highlight points of interest." (Journal of the Intensive Care Society, April 2010)

• Contributors viiPreface ix1 Introduction 1Mitchell M. Levy2 Defining the Spectrum of Disease 5Ron Daniels3 Identifying the Patient with Sepsis 10Ron Daniels4 Serious Complications of Sepsis 15Hentie Cilliers Tony Whitehouse and Bill Tunnicliffe5 The Pathophysiology of Sepsis 20Edwin Mitchell and Tony Whitehouse6 Initial Resuscitation 25Tim Nutbeam7 Microbiology and Antibiotic Therapy 29Partha De and Ron Daniels8 Infection Prevention and Control 36Fiona Lawrence Georgina McNamara and Clare Galvin9 The Role of Imaging in Sepsis 42Morgan Cleasby10 Presentations in Medical Patients 48Nandan Gautam11 Presentations in Surgical Patients 57Jonathan Stewart and Sian Abbott12 Special Cases: The Immunocompromised Patient 62Manos Nikolousis13 The Role of Critical Care 68Julian Hull14 Monitoring the Septic Patient 73David Stanley15 Novel Therapies in Sepsis 78Gavin D. Perkins and David R. Thickett16 Approaches to Achieve Change 83Julian F. Bion and Gordon D. RubenfieldIndex 87

Dr Ron Daniels MB ChB FRCAConsultant in Anaesthesia and Critical Care Lead Clinican, Critical Care Outreach, Good Hope Hospital, Birmingham, UKChair: Surviving Sepsis Campaign United Kingdom Steering Committee Survive SEPSIS Programme Director Dr Tim Nutbeam MB ChBTrainee in Emergency Medicine/Intensive Care MedicineEditor: Survive SEPSIS (the educational programme of the international Surviving Sepsis Campaign)

"The book's illustrations are superb. At the beginning of each chapter, an overview is presented, helping to succinctly outline the key points in the chapter. Tables and boxes are employed to outline key diagnostic and treatment points. There are a number of clinical pictures along with radiographic images to help highlight points of interest." (Journal of the Intensive Care Society, April 2010)

• Contributors viiPreface ix1 Introduction 1Mitchell M. Levy2 Defining the Spectrum of Disease 5Ron Daniels3 Identifying the Patient with Sepsis 10Ron Daniels4 Serious Complications of Sepsis 15Hentie Cilliers Tony Whitehouse and Bill Tunnicliffe5 The Pathophysiology of Sepsis 20Edwin Mitchell and Tony Whitehouse6 Initial Resuscitation 25Tim Nutbeam7 Microbiology and Antibiotic Therapy 29Partha De and Ron Daniels8 Infection Prevention and Control 36Fiona Lawrence Georgina McNamara and Clare Galvin9 The Role of Imaging in Sepsis 42Morgan Cleasby10 Presentations in Medical Patients 48Nandan Gautam11 Presentations in Surgical Patients 57Jonathan Stewart and Sian Abbott12 Special Cases: The Immunocompromised Patient 62Manos Nikolousis13 The Role of Critical Care 68Julian Hull14 Monitoring the Septic Patient 73David Stanley15 Novel Therapies in Sepsis 78Gavin D. Perkins and David R. Thickett16 Approaches to Achieve Change 83Julian F. Bion and Gordon D. RubenfieldIndex 87