High-Throughput Analysis in the Pharmaceutical Industry

Inbunden, Engelska, 2008

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Beskrivning

The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the bottleneck, a corresponding revolutionary improvement to the conventional methodology must happen.

Produktinformation

Utgivningsdatum:2008-08-20
Mått:178 x 254 x 27 mm
Vikt:954 g
Format:Inbunden
Språk:Engelska
Antal sidor:426
Förlag:Taylor & Francis Inc
ISBN:9781420059533

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Perry G. Wang

Recensioner i media

This book, edited by Perry G. Wang, provides excellent up-to-date reviews on the newest developments of high-throughput analysis in drug discovery and development ... has a good balance of both theoretical and practical information that should appeal to a broad base of readers ... remains as a quick and valuable resource for the readers, ranging from professionals to academics, to gain knowledge about the most recent developments of high-throughput analysis in the pharmaceutical industry. - Keyang Xu, Genentech, Inc., 2009 ... an appropriate and timely contribution to the scientific literature. ... offers valuable details and insights into each research area. ... very helpful to both newcomers to the field, as well as industry veterans. -Dr. James N. Kyranos, FORMA Therapeutics (US), in ChemMedChem 2009, vol. 4

Innehållsförteckning

High-Throughput Sample Preparation Techniques and Their Application to Bioanalytical Protocols and Purification of Combinatorial Libraries. On-line Sample Extraction Coupled with Muliplexing Strategy to Improve Throughput. Optimizing LC/MS Equipment to Increase Throughput in Pharmaceutical Analysis. Throughput Improvement of Bioanalytical LC/MS/MS by Sharing Detector between HPLC Systems. High-Throughput Strategies for Metabolite Identification in Drug Discovery. Utilizing Microparallel Liquid Chromatography for High-Throughput Analyses in the Pharmaceutical Industry. Strategies and Techniques for Higher Throughput ADME/PK Assays. High-Throughput Analysis in Drug Metabolism During Early Drug Discovery. High-Throughput Analysis in Support of Process Chemistry and Formulation Research and Development in the Pharmaceutical Industry. Online Solid Phase Extraction LC/MS/MS for High-Throughput Bioanalytical Analysis. Applications of High-Throughput Analysis in Therapeutic Drug Monitoring. High-Throughput Quantitative Pharmaceutical Analysis in Drug Metabolism and Pharmacokinetics Using Liquid Chromatography–Mass Spectrometry. Designing High-Throughput HPLC Assays for Small and Biological Molecules. Advances in Capillary and Nano HPLC Technology for Drug Discovery and Development. High-Throughput Analysis of Complex Protein Mixtures by Mass Spectrometry. Index