Anthony V. Rawlings, James J. Leyden

"Researchers, geneticists and academicians specializing in the study of skin barrier function and keratinazation disorders will be delighted to add this book to their library.""The chapters devoted to Atopic Dermatitis contains some of the best explanations for the pathogenesis of eczema that I have encountered.""I would highly recommend it to any dermatologist interested in critically evaluating and designing the perfect moisturizer".-Patricia Wong, MD (Stanford University Medical Center)

• Epidermal Differentiation. Lipid Organization of the Skin Barrier. Untangling the Role of Keratin in Stratum Corneum. Filaggrin. Peptidylarginine Deiminases in Skin Biology. Cornified Envelope. Corneodesmosomal Proteins. Kallikrein-Related Peptidases. Aquaporins and Tight Junctions. Epidermal pH. The Molecular Aspects of Dry Flaky Skin Conditions. Xerotic Skin Conditions and SC Properties. Skin Barrier Dysfunction in Atopic Dermatitis. Self-Perceived Sensitive Skin. Psychological Stress and Dry Skin. Stratum Corneum Biomechanics. Glycerol as Humectant. Lanolin and the Skin. Moisturization Mechanisms. The Effects of Niacinamide-Containing Moisturizers. Urea as a Moisturizing and Barrier-Enhancing Ingredient. Hydroxyacids and Salicylic Acid. Stratum Corneum Serine Proteases and Effect of Inhibitors on Dry Skin. Cannabinoids and Pruritus. Microdermabrasion. Cosmetic Benefits Derived from the Topical Application of Acid Proteases. Skin Moisturization by Dermonutrition. Capacitance Imaging for Viewing and Measuring Skin Surface Hydration. Vibrational Imaging and Microspectroscopy. Measuring Water Gradients Using Confocal Raman Miscrospectroscopy. New Developments in Skin Barrier Measurements.