Myelodysplastic Syndromes

Written by a team of leading authorities in pathogenesis, diagnostic techniques, and clinical management strategies in myelodysplastic syndrome (MDS), this text provides a concise, easy-to-follow review of the advances in the science, classification, diagnosis, and management of the condition. An ideal source for hematologists, oncologists, and cancer researchers, this Second Edition features:a new eight-page color insert200 color and black-and-white illustrationsreworked content organized into three sections: MDS epidemiology and biology; diagnosis, classification, and prognosis; and MDS therapythoroughly updated chapters reflecting a shift from the topical focus as dictated by the evolution of the fieldNew topics in Myelodysplastic Syndrome include:del(5q) and 5q-syndrome, CMML, and MDS-MPD overlap syndromethe reborn DNA methyltransferase inhibiting nucleoside analogsthe diagnosis of chronic myelomonocytic leukemia and other MDS cases with myeloproliferative featuresthe role of mitochondria and the potential importance of iron overload in MDSglobal genomics approaches, such as cDNA expression arrays, array-based comparative genomic hybridization, and single nucleotide polymorphism arraythe role of abnormal mitochondrial ferritin accumulation and other mitochondrial metabolic anomalies in MDother disease-associated alterations, such as abnormalities of B lymphocyte populations in MDthree recently approved drugs: azacitidine, lenalidomide, and decitabine