Nanoparticles in the Lung

Akira Tsuda is a principal research scientist in the Molecular and Integrative Physiological Sciences Program at the Harvard School of Public Health. He is the author of more than 100 peer-reviewed articles and mentor of postdoctors (Harvard School of Public Health and Harvard Medical School). He serves as a reviewer for many international scientific journals, as well as research grants. He was a member of the NIH Respiratory Physiology, Respiratory Integrative Biology, and Translational Research Study Section, and is currently on the editorial board of the Journal of Applied Physiology and Journal of Aerosol Medicine and Pulmonary Drug Delivery.Peter Gehr is a professor emeritus at the University of Bern. Previously, he was chair of the Institute of Anatomy. He has served as visiting assistant professor at the Harvard School of Public Health and guest professor at the University of Nairobi. He spent sabbaticals at the University of Western Australia, National Jewish Health in Denver, and Harvard School of Public Health. He is currently the president of the Steering Committee of the National Research Program on Opportunities and Risks of Nanomaterials of the Swiss National Science Foundation, and a member of the Swiss Federal Commission for Air Hygiene.

"The book presents the state of our current knowledge of the pulmonary-nanoparticle interface in a balanced, extensively researched way… This is a great reference text that I would want on my bookshelf. It also should be on the bookshelves of all students of nanomedicine."—Ellis H. Tobin, M.D., Albany Medical College and SUNY College of Nanoscale Science and Engineering, New York, USA"This book is an incredibly timely and relevant contribution to the scientific community, as nanotechnology advances at breakneck pace. Emerging medical applications as well as the potential for unwanted or adverse health effects due to nanoparticle exposures are both addressed in detail. This work will serve as an excellent resource for researchers, clinicians, public health professionals, and others who are working to advance the state of the science where nanoparticles and the respiratory track collide."–Sara Brenner, MD, MPH, SUNY Polytechnic Institute, Colleges of Nanoscale Science and Engineering, Albany, New York, USA

• Introduction. Deposition. Interaction with the Lung Surface. Role of the Biomolecule Corona in Nanoparticle Fate and Behavior. Interaction with Alveolar Lining Fluid. Interaction with Lung Macrophages. Interactions with Alveolar Epithelium. Mechanistic Aspects of Cellular Uptake. Cellular Uptake and Intracellular Trafficking. Translocation across the Air–Blood Tissue Barrier. The Pulmonary Lymphatic System. Translocation and Accumulation in the Body. Practical Considerations for Drug Delivery to the Respiratory Tract. Drug and Gene Delivery in the Lungs. Bio-Nanocapsules: Novel Drug Delivery. Physicochemical, Colloidal, and Transport Properties. Dosimetry for In Vitro Nanotoxicology: Too Complicated to Consider, Too Important to Ignore. Potential for Nose-to-Brain Delivery of Drugs. The Developing Lungs. Nanotoxicology. Summary.