Comparative Gene Finding

Models, Algorithms and Implementation

AvMarina Axelson-Fisk

Häftad, Engelska, 2016

Del 20 i serien Computational Biology

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Beskrivning

This book presents a guide to building computational gene finders, and describes the state of the art in computational gene finding methods, with a focus on comparative approaches. Fully updated and expanded, this new edition examines next-generation sequencing (NGS) technology. The book also discusses conditional random fields, enhancing the broad coverage of topics spanning probability theory, statistics, information theory, optimization theory and numerical analysis. Features: introduces the fundamental terms and concepts in the field; discusses algorithms for single-species gene finding, and approaches to pairwise and multiple sequence alignments, then describes how the strengths in both areas can be combined to improve the accuracy of gene finding; explores the gene features most commonly captured by a computational gene model, and explains the basics of parameter training; illustrates how to implement a comparative gene finder; examines NGS techniques and how to build a genome annotation pipeline.

Produktinformation

Utgivningsdatum:2016-10-05
Mått:155 x 235 x 22 mm
Vikt:610 g
Format:Häftad
Språk:Engelska
Serie:Computational Biology
Antal sidor:382
Upplaga:2
Förlag:Springer London Ltd
ISBN:9781447168751

Utforska kategorier

Biovetenskap inom Naturvetenskap och teknik

Recensioner i media

"The structure of the book mirrors the learning steps for understanding how to perform gene finding. ... Its target audience is mainly post-graduate researchers or established researchers with a background in mathematics or statistics applied in bioinformatics who need a thorough yet concise overview of this field." (Irina Ioana Mohorianu, zbMATH 1350.92001, 2017) "It skillfully introduces readers to a difficult subject, while at the same time motivating them to enter this very important area. ... It is best suited for a graduate course or as an introduction for researchers not familiar with this field. ... this is an excellent introduction to comparative gene finding. ... I especially recommend this book to any computer scientist with an interest in current problems in bioinformatics." (Burkhard Englert, Computing Reviews, December, 2015)

Innehållsförteckning

Introduction.- Single Species Gene Finding.- Sequence Alignment.- Comparative Gene Finding.- Gene Structure Submodels.- Parameter Training.- Implementation of a Comparative Gene Finder.- Annotation Pipelines for Next Generation Sequencing Projects.