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Beskrivning
Immunomodulatory agents have been expressed in defined tissues or throughout the body, providing tools for studying the functional consequences of dysregulated expression of biologi cal response modifiers.
I. Autoimmunity.- 1. Intensification of Diabetes in B7-1 Transgenic Mice.- 2. A Transgenic Window on Self-Reactive T Lymphocytes.- 3. Induction and Breaking of Peripheral Tolerance.- 4. T-Cell Development and Tolerance in Virus-Specific Transgenic Models.- 5. Inflammatory Disease in HLA-B27 Transgenic Rats.- II. Autoimmunity, Infections.- 6. The Role of CD40 Ligand in Regulation of Immune Response.- 7. Adventures in Antigen Presentation.- 8. The Effect of MHC Encoding Transgenes on IDDM in NOD Mice.- 9. The Immunology of Leishmania Major Infection in Mice.- III. Cytokines, Co-Stimulators, Tumor Immunity.- 10. The Regulatory Functions of Co-Stimulators Revealed in Transgenic Mice.- 11. B7-Deficient Mice Reveal an Alternative Functional CTLA-4 Counterreceptor.- 12. Cytokine Transgenic Mice and Autoimmunity.- 13. Gaining Insights into the Ontogeny and Activation of T Cells Through the Use of Gene-Targeted Mutant Mice.- 14. B7-Mediated Co-Stimulation of T Cells: CTLA-4 Can Deliver Inhibitory Signals.- IV. Cytokine Deletions.- 15. Lymphoid Organogenesis and Inflammation Are Mediated by Lymphotoxin.- 16. The Role of Interferon-? in the Development of Type I Diabetes.- 17. Cytokine-Deficient Mouse Mutants.- Author Index.
