Genotoxicity and DNA Repair

A Practical Approach

AvL. María Sierra,Isabel Gaivão

Inbunden, Engelska, 2014

Del i serien Methods in Pharmacology and Toxicology

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Beskrivning

Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields.

Produktinformation

Utgivningsdatum:2014-08-22
Mått:178 x 254 x 25 mm
Vikt:1 024 g
Format:Inbunden
Språk:Engelska
Serie:Methods in Pharmacology and Toxicology
Antal sidor:483
Upplaga:2014
Förlag:Humana Press Inc.
ISBN:9781493910670

Utforska kategorier

Farmakologi inom Medicin
Medicinsk genetik inom Medicin

Innehållsförteckning

Ames Test (Bacterial Reverse Mutation Test): Why, When, and How to Use.- The Ames II and Ames MPF Penta I Assay: A Liquid Microplate Format Modification of the Classic Ames Test.- Revised Procedure of the Bacterial Reverse Mutation Test for Genotoxic Evaluation of Nanoparticles.- The Control of Hydrophobic Compound Exposure in In Vitro Tests for Genotoxicity.- The In Vitro Micronucleus Assay and FISH Analysis.- The In Vivo Rodent Micronucleus Test.- Chromosomal Aberration Test Utilities In Vitro and In Vivo.- Chromosome Painting of Mouse Peripheral Blood and Spleen Tissues.- T-Cell Receptor Mutation Assay for Monitoring Human Genotoxic Exposure.- The Human RBC PIG-A Gene Mutation Assay.- The Applicable Use of the HPRT Gene Mutation Assay as a Practical Tool in Mutagenesis and DNA Repair Studies.- The Comet Assay: High Throughput Use of FPG.- The Comet Assay In Vivo in Humans.- Analysis of Nanoparticle-Induced DNA Damage by the Comet Assay.- The Comet Assay in Drosophila: Neuroblast and Haemocyte Cells.- The SMART Assays of Drosophila: Wings and Eyes as Target Tissues.- Testing the Genotoxic Potential of Nanomaterials Using Drosophila.- Transgenic Rodent Gene Mutation Assay in Somatic Tissues.- The Mouse Lymphoma Assay.- Bhas 42 Cell Transformation Assay for Genotoxic and Non-Genotoxic Carcinogens.- Methods for Measuring DNA Repair: Introduction and Cellular Repair.- A Standardized Protocol for the In Vitro Comet-Based DNA Repair Assay.- Use of the Comet Assay to Study DNA Repair in Drosophila melanogaster.- Use of RNA Interference to Study DNA Repair.- The LacZ Plasmid-Based Transgenic Mouse Model: An Integrative Approach to Study the Genotoxicity of Nanomaterials.