G Protein-Coupled Receptors Handbook

Häftad, Engelska, 2010

Del i serien Contemporary Clinical Neuroscience

2 117 kr

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Beskrivning

Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.

Produktinformation

Utgivningsdatum:2010-12-01
Mått:152 x 229 x 24 mm
Vikt:800 g
Format:Häftad
Språk:Engelska
Serie:Contemporary Clinical Neuroscience
Antal sidor:412
Förlag:Humana Press Inc.
ISBN:9781617375224

Utforska kategorier

Biovetenskap inom Naturvetenskap och teknik

Recensioner i media

"...provides an excellent resource to introduce the reader to many of the diverse areas and questions that drive research in the GCPR field." -TRENDS in Endocrinology and Metablosim

Innehållsförteckning

GPCRs: Structure and Function.- Structure—Function Relationships in G Protein-Coupled Receptors.- Molecular Mechanisms Involved in the Activation of Rhodopsin-Like Seven-Transmembrane Receptors.- GPCR Folding and Maturation.- Regulated Membrane Trafficking and Proteolysis of GPCRs.- GPCR Activity and Its Regulators.- Heterotrimeric G Proteins and Their Effector Pathways.- RGS Proteins.- G Protein-Coupled Receptor Kinases.- Regulators of GPCR Activity.- GPCR Interacting Proteins.- GPCR Dimerization/Oligomerization.- Biophysical and Biochemical Methods to Study GPCR Oligomerization.- Oligomerization Domains of G Protein-Coupled Receptors.- Functional Complementation and the Analysis of GPCR Dimerization.- The Role of Oligomerization in G Protein-Coupled Receptor Maturation.- Receptor Oligomerization and Trafficking.- Modulation of Receptor Pharmacology by G Protein-Coupled Receptor Dimerization.- Recent Developments in Drug Discovery.- Role of Heteromeric GPCR Interactions in Pain/Analgesia.- Conformational Plasticity of GPCR Binding Sites.- De-Orphanizing GPCRs and Drug Development.