Professor Dennis Smith has worked in the pharmaceutical industry for 32 years after gaining his Ph.D from the University of Manchester. For 20 years he was at Pfizer Global Research and Development, Sandwich where he was Vice President-Pharmacokinetics, Dynamics and Metabolism. For the past 2 years he has been a Pfizer Academic Research Fellow working on a part-time basis. His research interests and publications span all aspects of Drug Discovery and Development particularly where drug metabolism knowledge can impact on the design of more efficacious and safer drugs. During this 30-year span he has helped in the Discovery and Development of eight marketed NCEs. He has authored over 100 publications including two books.

• Drug targets and their structural motifs;ADMET for the medicinal chemist;Carboxlic acids and their isosteres;Primary, secondary and tertiary amines and isosteres;Sulphonamide as an essential group;1, 2 and 3 ring phenyl and heterocyclic cores;Heterocycles and phenyls as essential pharmacophore groups;Peptides and peptidomimetic cores;Peptides and peptidomimetics as functional groups;Transition state functions;Alcohols and carbonyls;Future targets and chemistry needs;

Professor Dennis Smith has worked in the pharmaceutical industry for 32 years after gaining his Ph.D from the University of Manchester. For 20 years he was at Pfizer Global Research and Development, Sandwich where he was Vice President-Pharmacokinetics, Dynamics and Metabolism. For the past 2 years he has been a Pfizer Academic Research Fellow working on a part-time basis. His research interests and publications span all aspects of Drug Discovery and Development particularly where drug metabolism knowledge can impact on the design of more efficacious and safer drugs. During this 30-year span he has helped in the Discovery and Development of eight marketed NCEs. He has authored over 100 publications including two books.

• Drug targets and their structural motifs;ADMET for the medicinal chemist;Carboxlic acids and their isosteres;Primary, secondary and tertiary amines and isosteres;Sulphonamide as an essential group;1, 2 and 3 ring phenyl and heterocyclic cores;Heterocycles and phenyls as essential pharmacophore groups;Peptides and peptidomimetic cores;Peptides and peptidomimetics as functional groups;Transition state functions;Alcohols and carbonyls;Future targets and chemistry needs;

Professor Dennis Smith has worked in the pharmaceutical industry for 32 years after gaining his Ph.D from the University of Manchester. For 20 years he was at Pfizer Global Research and Development, Sandwich where he was Vice President-Pharmacokinetics, Dynamics and Metabolism. For the past 2 years he has been a Pfizer Academic Research Fellow working on a part-time basis. His research interests and publications span all aspects of Drug Discovery and Development particularly where drug metabolism knowledge can impact on the design of more efficacious and safer drugs. During this 30-year span he has helped in the Discovery and Development of eight marketed NCEs. He has authored over 100 publications including two books.

• Drug targets and their structural motifs;ADMET for the medicinal chemist;Carboxlic acids and their isosteres;Primary, secondary and tertiary amines and isosteres;Sulphonamide as an essential group;1, 2 and 3 ring phenyl and heterocyclic cores;Heterocycles and phenyls as essential pharmacophore groups;Peptides and peptidomimetic cores;Peptides and peptidomimetics as functional groups;Transition state functions;Alcohols and carbonyls;Future targets and chemistry needs;