Functional and Molecular Glycobiology

Dr SusanBrooks, Dr M Dwek, Udo Schumacher

• Ch 1. An introduction to carbohydrate chemistry. Ch 2. Enzymes of glycosylation - the glycosyltransferases. Ch 3. Polysaccharides. Ch 4. N-linked glycoproteins. Ch 5. O-linked (mucin-type) glycoproteins. Ch 6. O-glcnac glycosylation of nuclear and cytosolic proteins. Ch 7. Species specific and unusual types of glycoprotein glycosylation. Ch 8. Glycoconjugates of the extracellular matrix of animals. Ch 9. Glycosphingolipids. Ch 10. Glycan chain extension and some common and important glycan structures. Ch 11. Sialic acids. Ch 12. Glycosylphosphatidylinositol (gpi)-anchored proteins. Ch 13. Carbohydrate-binding proteins (lectins). Ch 14. Tools for carbohydrate analysis. Ch 15. Modulation of glycan expression using inhibitors of N- and O-linked glycoconjugate processing, and transgenic technology. Ch 16. Disease processes in which carbohydrates are involved. Ch 17. Carbohydrate-based therapeutics. Ch18. Carbohydrate biotechnology.