Edited by Paolo Curatolo, Università degli Studi di Roma 'Tor Vergata'

"The previous giant of tuberous sclerosis was Manuel Gomez of the Mayo Clinic. The present giant is surely Paolo Curatolo. Others will surely stand on his shoulders, some of whom may have their enthusiasm first lit by reading this book. Pediatric neurologists, make sure you have it." Journal of Pediatric Neurology

• Index. Foreword by H. Sarnat.Preface Historical background, Paolo Curatolo Diagnostic criteria, Paolo Curatolo Neurological manifestations, Paolo Curatolo and Magda Verdecchia Seizures, Paolo Curatolo and Stefano Seri Intellectual and cognitive impairments, Patrick F. Bolton Autism, Michael Dowling and Paolo Curatolo Neuroimaging, Alessandro Bozzao, Guglielmo Manenti and Paolo Curatolo Positron emission tomography, Eishi Asano, Diane C. Chugani and Harry T. Chugani Dermatologic and stomatologic manifestations, Sergiusz Jozwiak and Robert Schwartz Ophthalmologic manifestations, Sergiusz Jozwiak Renal involvement, Sergiusz Jozwiak Cardiac and vascular involvement, Sergiusz Jozwiak Hepatic, lung, splenic and pancreatic involvement, Sergiusz Jozwiak and Paolo Curatolo Molecular genetics, David J. Kwiatkowski, Mary Pat Reeve, Jeremy P. Cheadle and Julian R. Sampson Neuropathology, Masashi Mizuguchi and Okio Hino Molecular neurobiology, Peter B. Crino Future directions, Paolo Curatolo