International Review of Child Neurology – serie

Peripheral neuropathies are diseases which affect the neuromuscular apparatus between the muscles or sensory receptors and connections in the spinal cord and the brain. They affect approximately 20-30% of children attending neuromuscular clinics. Uniquely, this text deals exclusively with such disorders in children and draws together the rapidly expanding but widely scattered knowledge in the field. It is a highly practical text, written by clinical neurologists with long experience in physiology, histopathology and management of neuropathy. This second edition retains the basic structure of its successful predecessor and continues to be liberally illustrated with real case histories. However, extensive revisions and expansion of the text have enabled it to encompass the major developments, including recent advances in molecular biology and therapy of metabolic and inflammatory neuropathies.

This book, the latest in the International Child Neurology Review series, is the first authoritative synthesis of the role of vitamin treatments in children with neurological disorders. It covers all the conditions seen in paediatric neurology that are treatable by vitamin supplementation and consists of up-to-date, concise reviews by an international group of experts in their specific fields. They cover: biotinidase deficiency; the role of vitamins in the developing nervous system, mitochondrial disorders and autism; homocysteinuria; conditions responsive to vitamin E or riboflavin; disorders of folic acid and vitamin B12 metabolism; folinic acid responsive seizures, and all aspects of pyridoxine-dependent and pyridoxine-responsive seizures. It is the first time that clinical and data research in this field has been drawn together in one source, making available previously unpublished material. This will be a unique data resource for anyone involved in the care of children with vitamin-responsive neurological disorders.

Disorders of Neuronal Migration addresses the various aspects of neuronal migration disorders in an ordered way. It will help the clinician to acquire insight as well as proficiency in diagnosis. Individual chapters describe subgroups including: lissencephalies subependymal heterotopia non-lissencephalic cortical dysplasias anomalies of the corpus callosum hemimegalencephaly schizencephaly polymicrogyria and multisystem disorders with impaired migration such as chromosomal and metabolic syndromes. Neuroradiological and genetic data are provided with the respective chapters.Although the book is intended for clinical practice, it provides core information for all interested in this important biological process.

The field of stroke and cerebrovascular disease in children is one in which there has been much recent research activity, leading to new clinical perspectives. This book for the first time summarises the ?state of the art? in this field. A team of eminent clinicians, neurologists and researchers provide an up-to-the-minute account of all aspects of stroke and cerebrovascular disease in children, ranging from a historical perspective to future directions, through epidemiology, the latest neuroimaging techniques, neurodevelopment, co-morbidities, diagnosis and treatment. The authors? practical approach to the clinical problems makes this essential reading for practising clinicians. It will also be of interest to researchers in the field.

"This is clearly the most authoritative and contemporary statement of current knowledge yet published." from the Foreword by H. SarnatTuberous sclerosis is the prototype of a category of malformations uniquely characterized by disturbances in cellular differentiation and growth. It presents with a complex association of different neurological phenotypes, including seizures, cognitive impairments and autism. It is important not only because it is a relatively common hereditary neurological disease with high morbidity, but because it has implications in other pathological processes, such as dysplasia and neoplasia, hamartoma formation and other disturbances in morphogenic processes. This book correlates new genetic data and basic science, covers clinical presentation, reviews the historical background and current diagnostic criteria, and deals with the recent advances in neuropathology, molecular genetics and neurobiology which give a better understanding of the pathogenesis of the disease. Paediatricians and child neurologists will find this book uniquely useful.

Written by child neurologists, this comprehensive, multi-authored volume on autism systematically discusses the classification, epidemiology and neurobiology of autism. Autism lacks a unique etiology or specific pathology, so the behaviorally defined social deficits, language impairments and repetitive behaviors that define autism are explored from a developmental neurology perspective. The evidence suggesting that autism is a disorder of neuronal development is reviewed by experts on the genetics, neuroanatomy and neuroradiology, neurochemistry, immunology, and neurophysiology of autism. Chapters provide comprehensive reviews of the common neurological problems associated with autism such as epilepsy, sleep disturbances and motor and sensory deficits. Neuropsychological assessment, medical and psychopharmacologic management, educational and behavioral interventions, and outcome are discussed within the clinical content of the practising neurologist. The research agenda needed to understand the neurology of autism is emphasized throughout the book and in the conclusion.

This is a comprehensive framework for the care needed by children and their famiies following a traumatic brain injury.

Neurodevelopmental disabilities are a common problem in child health. This book takes a comprehensive approach to addressing these often challenging clinical diagnoses. In particular, it focuses on the two most common of childhood neurodevelopmental disabilities: global developmental delay and developmental language impairment. It seeks to put forward our present conceptualization of these entities as well as their proper evaluation and assessment and diagnosis from a variety of perspectives. It also provides details on our current understanding of the scientific basis of these disorders and their underlying causes. Issues related to medical management, rehabilitation, and eventual outcomes are also addressed in a detailed way. The book has wide appeal to those in paediatrics, developmental paediatrics, child neurology, and paediatric rehabilitation. Its geographic appeal includes both developed and developing nations as some chapters are devoted to the particular issues faced in underdeveloped countries. The book’s focus on both clinical and scientific aspects is invaluable in this field. It also provides extensive information in a single source relating to often-overlooked areas such as medical management, rehabilitation, public policy, and ethics.

Pediatric Clinical Neurophysiology introduces clinical neurophysiology and its applications to the paediatric neurologist. It does not aim at being a textbook of either clinical neurophysiology or paediatric neurology, but to bridge these entities, as a handbook for the clinician. The focus is on the methods applied in the setting of a clinical neurophysiological laboratory. Pediatric Clinical Neurophysiology will stimulate readers’ interest in paediatric clinical neurophysiology in their daily clinical work with children.

This title has been developed with the International Child Neurology Association to provide information on all common CNS infections. It covers almost all CNS infections commonly seen in children across the world including those in developed and resource poor countries. It provides concise, state of the art overview of viral, bacterial, tubercular, fungal, parasitic and many other infections of the CNS. In addition involvement of the CNS secondary to other infections or vaccines has also been briefly covered. A chapter on Principles of Management of CNS Infections provides a practical and pragmatic approach to management of CNS infections in general. A chapter on ‘Neuroimaging of CNS Infections’ and ‘A brief account of Febrile Seizures in Children’ is included. The book is intended to be of practical use to residents, physicians, paediatricians and paediatric neurologists across the globe. It should be particularly helpful in providing important information in an easily accessible and comprehensive format, with supporting references.

A better understanding of neural activity and the development of cortical connections and networks is an important requirement for evaluating the cause and treatment of neonatal seizures. There have been many advances in the management of neonatal seizures such as increased use of EEGs, therapeutic hypothermia for HIE and exome sequencing, to name a few. Neonatal Seizures, Current Management, Future Challenges distils what is known about these advances into one scholarly yet practical text.

International Reviews of Child Neurology Series No. 13Given the tremendous advances in the last five years in the understanding of acquired neonatal brain injury and in the care of affected newborn infants, this book provides a timely review for the practising neurologist, neonatologist and pediatrician.The editors take a pragmatic approach, focusing on specific populations encountered regularly by the clinician. They begin by addressing aspects of fetal neurology and the interpretation of fetal imaging studies. They then follow a “bench to bedside” approach to acquired brain injury in the preterm and term newborn infant in the next chapters. The contributors, all internationally recognized clinician scientists, provide the clinician reader with a state-of-the art review in their area of expertise. The final section of the book address special populations and concerns, areas that are largely overlooked in existing neurology textbooks. Each of these areas has seen considerable advances in the last five years and is of increasing relevance to the neurologist and neonatologist clinician. The comprehensive nature of each section (from basic science to acute clinical care to outcomes) should appeal broadly to scientists and allied health professionals working in neonatal neurology.ReadershipPaediatric neurologists, neonatologists, neurologists and paediatricians, clinicians in child development, child health researchers and allied health professionals (in physiotherapy, occupational therapy, speech therapy and psychology).  Trainees in these areas.