Oral Delivery of Insulin

Sonia T.A pursued her PhD under the guidance of Dr Chandra P Sharma at the Biosurface Technology Division, Sree Chitra Tirunal Institute for Medical Science & Technology in Kerala, India. She worked in the field of development of polymeric nano/micro particles for oral delivery of insulin. She completed her graduate studies in Polymer science from the School of Chemical Sciences, Mahatma Gandhi University, Kerala India. She has presented her work in International Conferences. Dr. Chandra P. Sharma is an Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, and Hon. Emeritus Professor, College of Biomedical Engineering & Applied Sciences, Purbanchal University, Kathmandu, Nepal. Dr. Sharma is a Solid-State Physicist from IIT Delhi and received his training in Biomaterials area in the University of Utah with Prof. D.J. Lyman as a graduate student and in the University of Liverpool, England with Prof. D.F. Williams as a Post-Doctoral Research Associate. Dr. Sharma has been awarded FBSE (Fellow Biomaterials Science & Engineering) by The International Union of Societies for Biomaterials Science & Engineering (IUS-BSE) in 2008 and FBAO (Fellow Biomaterials and Artificial Organs) by Society for Biomaterials & Artificial Organs (India) (SBAOI) in 2011 and shares Whitaker and National Science Foundation Award – International Society for Artificial Organs (ISAO) USA, invited member ACS (2015-2018).

"...a comprehensive account of the status of oral insulin delivery...any scientist beginning work in the field should read their book…" --International Journal of Pharmaceutics

• List of figures and tablesFiguresTablesAbout the authors1: Diabetes mellitus – an overviewAbstract1.1 Diabetes mellitus – an introduction1.2 Glucose homeostasis1.3 Types of diabetes1.4 Symptoms of diabetes1.5 Complications of diabetes1.6 Diagnosis of diabetes mellitus1.7 Therapy for diabetes1.8 Non-insulin treatment options of type 1 diabetes1.9 Treatment options of type 2 diabetes1.10 Conclusion2: Routes of administration of insulinAbstract2.1 Current approach for the delivery of insulin2.2 Routes of administration of insulin2.3 Conclusion3: Oral insulin delivery – challenges and strategiesAbstract3.1 Oral delivery of insulin3.2 Barriers to oral delivery of insulin3.3 Strategies and alternatives to improve oral insulin delivery3.4 Conclusion4: Experimental techniques involved in the development of oral insulin carriersAbstract4.1 Introduction4.2 Polymeric nanoparticles4.3 Physicochemical characterization of nanoparticles4.4 Biological evaluation4.5 In vitro method for assessing drug permeability4.6 In vivo study of oral insulin4.7 Biodistribution studies4.8 Conclusion5: Lipids and inorganic nanoparticles in oral insulin deliveryAbstract5.1 Lipid-based systems for oral delivery of insulin5.2 Liposomes5.3 Solid lipid nanoparticles5.4 Nanostructured lipid carriers5.5 Niosomes5.6 Archaeosomes5.7 Cubic nanoparticles (cubosomes)5.8 Aquasomes5.9 Inorganic nanoparticles as carriers for oral insulin delivery5.10 Conclusion6: Polymers in oral insulin deliveryAbstract6.1 Introduction6.2 Characteristics of an ideal oral insulin carrier6.3 Polymers in oral insulin delivery6.4 Natural polymers6.5 Synthetic polymers6.6 Conclusion7: Summary and future perspectives for oral insulin deliveryAbstract7.1 Introduction7.2 Technologies developed for clinical applications of oral insulin delivery7.3 Conclusions and future perspectivesIndex