mRNA Metabolism in Human Disease

Häftad, Engelska, 2020

Del 1157 i serien Advances in Experimental Medicine and Biology

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Beskrivning

The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism.

Produktinformation

Utgivningsdatum:2020-08-15
Mått:178 x 254 x 11 mm
Vikt:422 g
Format:Häftad
Språk:Engelska
Serie:Advances in Experimental Medicine and Biology
Antal sidor:180
Förlag:Springer Nature Switzerland AG
ISBN:9783030199685

Utforska kategorier

Onkologi inom Medicin
Medicinsk utrustning och medicinska tekniker inom Medicin
Medicinsk genetik inom Medicin

Mer om författaren

Luisa Romao is a principal investigator on the unit of hemoglobinopathies in the center of human genetics of the National Institute of Health Dr. Ricardo Jorge in Lisbon. She is a member of the RNA society.

Innehållsförteckning

Prelims.- Networks of mRNA processing and alternative splicing regulation in health and disease.- The diverse roles of RNA-binding proteins in glioma development.- Nonsense-mediated mRNA decay in development, stress and cancer.- Implication of mRNA degradation disorders on human DISease: focus on DIS3 and DIS3-like enzymes.- Translational regulation by upstream open reading frames and human diseases.- Alternative mechanisms of mRNA translation initiation in cellular stress response and cancer.- RNA therapeutics: how far have we gone? Index.