Fundamentals and Clinics of Deep Brain Stimulation

Yasin Temel is a Professor of Neurosurgery of Maastricht University Medical Center, Maastricht, The Netherlands. He is an expert in Deep Brain Stimulation and has published extensively on this topic. He edited the Dutch ‘Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen’ together with A. F.G. Leentjens and R.M.A. de Bie. Albert F.G. Leentjens is Professor of Neuropsychiatry at Maastricht University Medical Center, where he is in charge of the psychiatric DBS programme. Together with Y. Temel and R.M.A. de Bie he edited the Dutch DBS handbook: ‘Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen’.Prof. dr. Rob M.A. de Bie is the leader of the Movement Disorders group and the Neurodegeneration programme at Amsterdam Neuroscience, University of Amsterdam. His research focuses on improvement of treatment of Parkinson’s disease, including Deep Brain Stimulation, pharmacological treatment, and non-motor symptoms. Prof. de Bie focuses on complex clinical research and he has initiated several large clinical trials.Pr Stephan Chabardes is professor of neurosurgery at Grenoble Alpes University. He is the head of the functional and stereotactic unit at Grenoble-Alpes university hospital and of the Clinical unit at CLINATEC-CEA LETI. He is member of the executive committee of the ESSFN, member of the board of directors of the WSSFN and President of the Functional and Stereotactic section of the French Neurosurgery society. Pr Chabardes has participated to the publication of more than 160 peer reviewed papers and is currently heading different clinical trials on deep brain stimulation.Prof Alfonso Fasano is the co-director of the Surgical Program for Movement Disorders at Toronto Western Hospital, staff neurologist at Toronto Western Hospital and at the Sick Children Hospital, Toronto, ON, Canada. He is also a full professor of medicine in the Division of Neurology at the University of Toronto and a clinician investigator at the Krembil Research Institute, also in Toronto, Ontario, Canada. He is member of the CenteR for Advancing Neurotechnological Innovation to Application (CRANIA). His main areas of interest are the treatment of movement disorders with advanced technology (infusion pumps and neuromodulation), pathophysiology, and treatment of tremor and gait disorders.

“The book provides a wealth of information and can serve as a useful resource for all interested readers. … The text is accompanied by numerous color figures, schematic presentations, neuroradiological images, and photographs, which make the learning easy and exciting.” (Marina Raguž and Darko Chudy, Croatian Medical Journal, Vol. 62, 2021)

• Part I General Section.- 1. The History of Deep Brain Stimulation.- 2. Anatomy of Targets for Deep Brain Stimulation.- 3. Mechanisms of Deep Brain Stimulation.- 4. Surgical and Technical Aspects of Deep Brain Stimulation.- 5. Future Perspectives: Adaptive Deep Brain Stimulation.- 6. Neurophysiology of the Basal Ganglia and Deep Brain Stimulation.- 7. Anaesthesia for Deep Brain Stimulation Surgery.- 8. Programming: General Aspects.- 9. Neuropsychological Assessment.- 10. Ethical Considerations.- 11. Organisation of Care for Patients Treated by Deep Brain Stimulation.- Part II Neurology.- 12. Deep Brain Stimulation for Parkinson’s Disease.- 13. Tremor.- 14. Dystonia.- 15. Epilepsy.- 16. Gilles de la Tourette syndrome.- Part III Psychiatry.- 17. Deep Brain Stimulation in Obsessive-Compulsive Disorder.- 18. Deep Brain Stimulation for Depression.- 19. Other Indications for Deep Brain Stimulation.