Joana Vieira Silva; Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine – iBiMED, University of Aveiro, Portugal; Institute for Innovation and Health Research (i3S), University of Porto, Portugal; Department of Microscopy, Laboratory of Cell Biology, and Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Portugal; joanavieirasilva@ua.ptMaria João Freitas; Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Leuven, Belgium; mariajoao.freitas@kuleuven.beMargarida Fardilha; Laboratory of Signal Transduction, Institute for research in Biomedicine- iBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal; mfardilha@ua.pt

• Preface.- Tissue-specific cell signaling: introduction.- Beyond the brain signaling.- Cell signaling within pituitary, the master gland of the endocrine system.- Cell signaling within endocrine glands: thyroid, parathyroids and adrenal glands.- Signaling pathways governing activation of innate immune cells.- Cell activation and signaling in lymphocytes.- Signaling pathways involved in kidney and urinary tract physiology and pathology.- More than androgens: hormonal and paracrine signaling in prostate development and homeostasis.- Testicular signaling: team work in sperm production.- Sperm signaling specificity: from sperm maturation until oocyte recognition.- Hormone signaling pathways in the postnatal mammary gland.- Oogenesis signaling: from development to environmental plasticity and aging.- Key signaling pathways in the cardiovascular system.- Growth factor signaling in the maintenance of adult lung homeostasis.- The signaling pathways involved in the regulation of skeletal muscle plasticity.- Adipocyte-specific signaling.

Joana Vieira Silva; Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine – iBiMED, University of Aveiro, Portugal; Institute for Innovation and Health Research (i3S), University of Porto, Portugal; Department of Microscopy, Laboratory of Cell Biology, and Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Portugal; joanavieirasilva@ua.ptMaria João Freitas; Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Leuven, Belgium; mariajoao.freitas@kuleuven.beMargarida Fardilha; Laboratory of Signal Transduction, Institute for research in Biomedicine- iBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal; mfardilha@ua.pt

• Preface.- Tissue-specific cell signaling: introduction.- Beyond the brain signaling.- Cell signaling within pituitary, the master gland of the endocrine system.- Cell signaling within endocrine glands: thyroid, parathyroids and adrenal glands.- Signaling pathways governing activation of innate immune cells.- Cell activation and signaling in lymphocytes.- Signaling pathways involved in kidney and urinary tract physiology and pathology.- More than androgens: hormonal and paracrine signaling in prostate development and homeostasis.- Testicular signaling: team work in sperm production.- Sperm signaling specificity: from sperm maturation until oocyte recognition.- Hormone signaling pathways in the postnatal mammary gland.- Oogenesis signaling: from development to environmental plasticity and aging.- Key signaling pathways in the cardiovascular system.- Growth factor signaling in the maintenance of adult lung homeostasis.- The signaling pathways involved in the regulation of skeletal muscle plasticity.- Adipocyte-specific signaling.

Joana Vieira Silva; Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine – iBiMED, University of Aveiro, Portugal; Institute for Innovation and Health Research (i3S), University of Porto, Portugal; Department of Microscopy, Laboratory of Cell Biology, and Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Portugal; joanavieirasilva@ua.ptMaria João Freitas; Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Leuven, Belgium; mariajoao.freitas@kuleuven.beMargarida Fardilha; Laboratory of Signal Transduction, Institute for research in Biomedicine- iBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal; mfardilha@ua.pt

• Preface.- Tissue-specific cell signaling: introduction.- Beyond the brain signaling.- Cell signaling within pituitary, the master gland of the endocrine system.- Cell signaling within endocrine glands: thyroid, parathyroids and adrenal glands.- Signaling pathways governing activation of innate immune cells.- Cell activation and signaling in lymphocytes.- Signaling pathways involved in kidney and urinary tract physiology and pathology.- More than androgens: hormonal and paracrine signaling in prostate development and homeostasis.- Testicular signaling: team work in sperm production.- Sperm signaling specificity: from sperm maturation until oocyte recognition.- Hormone signaling pathways in the postnatal mammary gland.- Oogenesis signaling: from development to environmental plasticity and aging.- Key signaling pathways in the cardiovascular system.- Growth factor signaling in the maintenance of adult lung homeostasis.- The signaling pathways involved in the regulation of skeletal muscle plasticity.- Adipocyte-specific signaling.