Reactive Oxygen Species

Network Pharmacology and Therapeutic Applications

AvHarald H. H. W. Schmidt,Pietro Ghezzi

Häftad, Engelska, 2022

Del i serien Handbook of Experimental Pharmacology

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Beskrivning

Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants.

Produktinformation

Utgivningsdatum:2022-02-24
Mått:155 x 235 x 22 mm
Vikt:736 g
Format:Häftad
Språk:Engelska
Serie:Handbook of Experimental Pharmacology
Antal sidor:425
Förlag:Springer Nature Switzerland AG
ISBN:9783030685126

Utforska kategorier

Farmakologi inom Medicin
Kemi inom Naturvetenskap och teknik
Biovetenskap inom Naturvetenskap och teknik

Innehållsförteckning

Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine.- Demystifying oxidative stress.- Oxidants in Physiological Processes.- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies.- Part II Targeting antioxidant responses.- Development of Telintra as an Inhibitor of Glutathione S-Transferase P.- Perspectives on the Clinical Development of NRF2-Targeting Drugs.- Part III: Inhibiting ROS formation and toxification.- NOX Inhibitors: From Bench to Naxibs to Bedside.- Nitric Oxide Synthase Inhibitors into the Clinic at Last.- Xanthine Oxidoreductase Inhibitors.- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches.- Inhibition of Myeloperoxidase.- Part IV: Stimulating/substituting ROS.- Effects of Mammalian Thioredoxin Reductase Inhibitors.- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation.- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers.- Part V: Repairing ROS damage.- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander.- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.